{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022AjiGcPQXZRKu40n5aNRPi4MrCLrrcGYzshoy0VVt7JK41LxlhM\\\\\\\\\\\\\\\/30ASfPMBe2lw+6+iYbb3yldj5xjuMKDP2AKNUSW\\\\\\\\\\\\\\\/oku+W3tVz2ahHnznNJt0HJn\\\\\\\\\\\\\\\/JLHLV+peWYz48ldbqZCCjpYvhnaPfjbqXmi6455mBEYEj3HXMitICkTuGJinAFrzYVw+N++DS5iGvwRwqGGGzvaEnfw70d5p2Lqk7BNUHIoFvHFNX\\\\\\\\\\\\\\\/Hry2PM62VJUhoq4MNkV1duA5gnxdeM91zrHLCLqhZ8w2nu+paep2ixvz88Pd7c0bSfSHlkWttbwiQVBl7\\\\\\\\\\\\\\\/qyMVfhvUQotlh+uNQgiTz7hVZTHDTOT2fO9kOC7lzKanZPORghREG4BI3LEncJ6Gb5a68r498pJzC37D781z6OBGkb6vl47ajVmaynCUfzBx0vEoNL0DSO82bHkwv\\\\\\\\\\\\\\\/8Ddg6FKsHSGEL5iyqcqTFV4PyhSs\\\\\\\\\\\\\\\/T4eFfeCiD8L5X4rJARuqppvWQQf1JBdtPRCYZNxwxDcYeRgBZW853XfcAVE9zwbTHcy8ZpjUqPDeCurqMtGcST5wIc36+x292xji\\\\\\\\\\\\\\\/UwBFD6NUnKYio77cE6hq6ga40UKdseculE8WOz2Uiv8jpNgvSPoBOkv2l1ybVofBsZu+27se\\\\\\\\\\\\\\\/4OUHGHht+GjG9qagWUQU2qWPDDbWk8+BorpAkiZpzk6SueyXTEHJ4+EXtDkYPIOO8UKqXf2kkF4u6DhOWnEZzuLoPXndFM9ZH2FD8xu10WdNxd8C3B26MQAsBuwkp9hnO3e6pK4KBQt\\\\\\\\\\\\\\\/qibkdzCxTvO8IsCWn7SfYsWPhzwIcG7T8qmN6Akv2QBP3ml1nikAHAwMcP5UuQEnj5eZIxQgQBcy+qOEsbWXwZK1Gi3QuGajuNBmcLjOr\\\\\\\\\\\\\\\/fJhlJ+UdaW9ZGhTEClupnXCqNpS1pH1OZ3NKZXiirc3JsL0WEcXzQZ3HLiqBj90Lh5f28hpC3xymQfOgWILZTaYIBBMmgir\\\\\\\\\\\\\\\/1490WUJSkTJc8FavnIG1pEnbtY019zbMZcIe0GY7zPw4rBSlyVd7fOySKzqp\\\\\\\\\\\\\\\/0VMMC25E1iw8RfjUZSDTUkUuQoh5hopmcrr2B5qYCXhNQIb0dCEVViTz7Nt2QjSRAN9hbiuTGcMfjwmnqeUlTnX4d3faSFCX8\\\\\\\\\\\\\\\/dgg985rXDFf\\\\\\\\\\\\\\\/PCLsA5cDMnnn4KIpIk9YXOTdznWSaTfUaHduc1QsVoL+XOOdVOvPigAi\\\\\\\\\\\\\\\/ptsUkj0VngIiJVB3U6282xEUp+ZAD0+Ym3zLYRe42kGV\\\\\\\\\\\\\\\/jc3W9vuGGf49vy35drfNitEt5yq4fnj\\\\\\\\\\\\\\\/tT5UYSva4bxf2ek0\\\\\\\\\\\\\\\/FFzmXmEWmH\\\\\\\\\\\\\\\/CbfC7jPN3m86wQkpgoNs3GVPziN5JF\\\\\\\\\\\\\\\/CCeEJhGgASBj0PKeDpb7d+9TmgWIYO8jy8gKK8F3nfFN3IhbXgni\\\\\\\\\\\\\\\/Aycvaz4j3DQJBM8AaXogK8uy19vwLfDfh7gwW1AQo1UNU9TI12Y7g2oBBqzeZBddWQc24dWjuCj5KtowuSU+tZAwZdNWz\\\\\\\\\\\\\\\/FQGYpMWSq\\\\\\\\\\\\\\\/S6Xi5ic5BnKMc7BjiTk5Gqy\\\\\\\\\\\\\\\/mbYYd6jMRx6zFV6gFHQiciK7WLMsPuIqV7\\\\\\\\\\\\\\\/Lzn+SfVf2LJbZZ4g\\\\\\\\\\\\\\\/t7XYWAVgmkb4LJTbHCmygsLqOkOoUCBXYCAW3+cRoZIYXltN4nHsRTJVIessI1S++SGhaIZdJVrFN2NDrA\\\\\\\\\\\\\\\/rCaszj\\\\\\\\\\\\\\\/BvZXwpPGxuwB4o0+IytCHZSZrDpvuhkydQFQCemfaeYdWVh5gD4fzNHLgvMP1pFNqpsbKWa06LhESEwcM0CJxI6k+waXP8VMsDl4bxwNctHh4HE3ysO6n\\\\\\\\\\\\\\\/YyX4NKctFbMqd39s3dOmUzRQkN+99prucSkgEvgClP\\\\\\\\\\\\\\\/3Vhc\\\\\\\\\\\\\\\/Tes0uUSJA5oB0bSdruSolkgKiGit0a8wvvt7NH7RLIJnSzvqvus2uA2PS8YnNnPn7AakqdCAqX8a4xyC8BgwcqIzz2HIjFn0ipAyB0YBb0BACsh0OOr41ne7G9ycFnY5CPrS17ObUuZBhbvH4AH4ltWcr\\\\\\\\\\\\\\\/AKmx71TgcvwzXV6xmBXPIpEU8dHYiQYE5VAMUPiqrApvroAuinO6OGVRnplTLIUXFpeJhO+GxPE2EA4hLT39WH1fHPtNyu8mh63pHlN11MCo\\\\\\\\\\\\\\\/Tt3m0VrXxueNZ8jfoZ1Pze4pcJ7Oy3AA3Y8RLKulOimWGTQAOP81hV+A3VkCWYrle2a2rlt5+NW\\\\\\\\\\\\\\\/OYJKzIxB1T8nBU7qUQ9hht4WAwBTtTiI4jN5eYYIp1zirNcn7x\\\\\\\\\\\\\\\/j198MKBXo6HBEBDb2y8vPmT0\\\\\\\\\\\\\\\/mFmeVRsMOENBhpQ86DBVXf6vaAwL7KPog4BH4BZzOyZsJRjsLFLn5a8jVRe8GNlfXyH4XkKECSdp6OJCzTHK2iYz865eEyaGLQ5ALFK6Z1gAOCEU8fHAIXNkdjXFWKviQE190AGIyDeID7JUvP1EbdMN5gcrKfwr+wh81FLXOdteu5gP44T65tH1sq0Hlt12lnxuNzhzyArzl2cJBaMjxQXiYbJsl2lVoJ2cLDYcLqZvF8yhrHY+M4LMd6Udos4Sx6FIng7t4iN88\\\\\\\\\\\\\\\/WLEBlDhTGT0zaZvMItRPXyoG1zZaz01b6SShroEvdtYWhivojTxguMYZ8MRT1AXABCuez2Wcojtz1PuLUmk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022U8RbdG\\\\\\\\\\\\\\\/DIUM2iGVTc5q\\\\\\\\\\\\\\\/hw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ae0e70dd4c6e718e82f0b8c18eb949d4800dc8bba25bcde192636e36756c50f9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/9\\\/e006013.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/9\\\/e006013.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006013\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006013\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006013\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}