{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022u+sOWqvK+R7SlbRhC2K5WaFPb5M+uUt7kCsKNbpMzjGsP\\\\\\\\\\\\\\\/UNc\\\\\\\\\\\\\\\/UXipv74HmIDeo4bSfkkeRaNchrDD5Qd+6TZhXEqrUA8tR8+RzHY6wW0tT\\\\\\\\\\\\\\\/qoS0MLsu9Y\\\\\\\\\\\\\\\/W1wy7\\\\\\\\\\\\\\\/RjyTa10xMWIIQszpRWpEwcfVCK7yBE7d9QTuH4Puj5fF+7K06rp4m8GHms7aWxRGR7iucotk+OsFfYDAB1OwAcFJJX4K3A3qK2mSWkjbNoDU4PvYF7dVpYYGriVwXIfCllpyCqZkcjSrnzfJdD\\\\\\\\\\\\\\\/1u8888qGWNdYSffgJfEQsRMxCIwwup3HygbPquSKltFcI48D5ihcIQfh+d46vxJmyKNsZ985HkdXsMQx5UXPKAJmB9eIn2ikZIeTkldfnb2TS4tYuZAVtoy\\\\\\\\\\\\\\\/JaXlMnTxnd44PQKpDekjwIOXBcywcUCdpJ+Mn3c\\\\\\\\\\\\\\\/1HWVUMgq78FsWMsB19POXSiSF4Mjjxq7Eq6OI1Fgz6FbXyEpMkIdCFxlurQD8pPM9aGoFdsTelIv9Ly3i3AARnTktxF7yMtDOONfMNo3L2ooD8E+PFsBtTldmNIhJ2ofHBB62n3X6SdlWRD7G4i9EwhT67th4o5gfscQhYeqBSTj2kpDRSCNbZZwqC705Idpv7uh7iKELR3MeZTk06euI68M2OMCl71J8hrhrfutYraTqe1sieqQgLrH92q7bla4rnxlcae4YrpWNKmZq8\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/TullfFCS+bkNxE\\\\\\\\\\\\\\\/ja9gbuQa+7pQyhC8pfX9pAFYEoYrcm1P7Z\\\\\\\\\\\\\\\/JsfMcgi5R8cNoV+rVpV3MOvqLaxGgKF\\\\\\\\\\\\\\\/4hwOagORtjUYyG3Loi8XbT3zqUvqTSPfJ\\\\\\\\\\\\\\\/7Q2MNrUTKOt+XiuLHj6K7ApLZ7Q4Ia1W1uaDJyD9UxDZSyDpmQ6CK3Koraw1AFbFZq7\\\\\\\\\\\\\\\/J5p1M2iH62AJrrGPXsLgnLChg02S7+DM51d2QEJtEdMEU+JvqZw28ND+8\\\\\\\\\\\\\\\/LAEppXq7o\\\\\\\\\\\\\\\/W9Fjr8BSkj\\\\\\\\\\\\\\\/r9aowyUu2mnc\\\\\\\\\\\\\\\/1wZ8PiQShxaZsJhlK6+qBYePKNMcoUWU+cOEAUbkjJxKnvHzptX4Y0yFRLSnnSScOSRY3nA5SrmJ6tXuT9icvfeBtU9F2xsdgg9pfQ6Cv\\\\\\\\\\\\\\\/9kdCgucMhBPDXbiSDygtRrV0k4gWQpYFdDwcOonOrJBoQqxifxVwtskrvZpQXJPWJ4JEtOH\\\\\\\\\\\\\\\/OGhQt5FYhl1s4AN8knbGDtO1pYF\\\\\\\\\\\\\\\/0JozKGiaeVbVOYc9o4lB9yzwMTPtiETq7WwnSmT1uAT3PVMefLSB\\\\\\\\\\\\\\\/A3jLYYcuvL4ilyKhPym15nBSZu+lMtQxqDXSR0nvB7IcAirppAzanEsNdQeYfJCUcESKfoCF0K94e2M8izuMCTatlc\\\\\\\\\\\\\\\/W60s\\\\\\\\\\\\\\\/Zk6ENALoN3YDAAgKIKV2vuYcPJknpq6TAlOUGcRZgSFZhV2lmTVkoN+N0GjQUdUXh7xWU\\\\\\\\\\\\\\\/0xB+BA9CgwxVJOe7si5\\\\\\\\\\\\\\\/5SThYMq83GsE9Ok+\\\\\\\\\\\\\\\/u41IDqf85qSSd77\\\\\\\\\\\\\\\/2CwoR67ndAOPbJvlEi986JZZrdbm3uY9WBxo\\\\\\\\\\\\\\\/2ksaWmL\\\\\\\\\\\\\\\/yNyeKrF6nkFJ6kCYM7NYsGcahQqqG8f84dIwLTilsrPNWMvhj4dbucgrWvjx03Ka6+1QDgFsK+VqbfvflHR+NCsQDgCHGicahZ5135BtCV78U\\\\\\\\\\\\\\\/cav0kID3\\\\\\\\\\\\\\\/eFWo91cq4ldeiA33yXJFNl\\\\\\\\\\\\\\\/w7I2CzSMEmRLUoNEcJT3lrH\\\\\\\\\\\\\\\/3pXKX7nY32y68O64\\\\\\\\\\\\\\\/m6yUqKBBFgU16rvu4Nw+TA16Fv2CGqHuDRz2lPwR85xKs2zeWGyyAgxk4KPOEKlrT1jeYDHhr6BS\\\\\\\\\\\\\\\/Czbde25vzveFYx7pI3DgUBFdkGj\\\\\\\\\\\\\\\/Tngh44o8Bod5VbZTbC5HLxAo3aEcWVsSHj\\\\\\\\\\\\\\\/RjPDipuLAtTSE42W+kaycE0bZ8UZp0OOSXDze5deKioFuKlipIBRaVOVxontOXPYknugiNcZqJoGTRxgUXLT5+lTu6LZnV47KbJThBv6IqPvuHFEz\\\\\\\\\\\\\\\/U+X9wpD4Yrwg1fm3XOO2e2aVWVi+z4Xzo6e0MFgf0O4AHkDKjI\\\\\\\\\\\\\\\/jOUFzigfn2\\\\\\\\\\\\\\\/v\\\\\\\\\\\\\\\/HRBCusp+ymBYsBh8CB9IppeGYkrbXokQCCf8q1yKd5LtNAoCy+DHE04SR8LqBmZkOEOQ6bxrvWlJOIxwVxusiBWZlYPPHkQHvH2xjzhceiJ2tTkjxtqO5n3G936bLyrmVv0dTsuUtq6EVXxTC8pPNzfPhfnBcl6Id3T3RphOa+mKiATMKH\\\\\\\\\\\\\\\/ejx0W2taYna+7E\\\\\\\\\\\\\\\/VfmBdYViqP6uUaCXPdv6EBs0yo87IebpMMDZ\\\\\\\\\\\\\\\/fFeHhIMRRpjQYK+T\\\\\\\\\\\\\\\/nwgxzLtsTXuXJxiDa9jl8joXE\\\\\\\\\\\\\\\/mv834Tav76X3zFtkngsxO6gq+IGCPMVyw\\\\\\\\\\\\\\\/PYrq2xzyYvKObrmbpBWKuDeplaPsz5HFrf2D8ZtraCxJeFBSvSDDtvFczZWQyqXFZVYp0iUtov9YSkyUFWU8MqXoZEI\\\\\\\\\\\\\\\/dn6fzeQ3wtTUqmp7JlghAp0IQ9QO3BIRXONRgnpyjpejmtU6d31vZG5t5iIpXod8cgKA0DFvcoIRhdEAUzCUVhHjS5OvgKcdojsIgQpr0TnbTSgzxmaHxhcMHkn+AxbZnt1JoVQvQ2e9ad\\\\\\\\\\\\\\\/FsRtAYAHz4Rte9R6JWVCNkyXAC+1lxGrrkQT5in\\\\\\\\\\\\\\\/T2XhD7tPIcI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022guda\\\\\\\\\\\\\\\/wgjSJM\\\\\\\\\\\\\\\/kjjX0xf3tw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002241c197706aa72eca9c6faae2462609fa6a88e97e73b6c247b38beebfa6bd901d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/9\\\/e007386.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/9\\\/e007386.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007386\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007386\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007386\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}