{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022U13exHbAmgAXp0MonA5q4yst+\\\\\\\\\\\\\\\/PxJAf1N2gsfMToW+zrYNI+4pOHrL\\\\\\\\\\\\\\\/9s7bybLk2aAgVmPVf4otyVHCuEHZPFqvvf9n4UpAu7G5PH9qC3aGgF0h0cwTkSUfP9VflOYWkTRWRzCvYbDnHn3hJIYTLtI6yUldRxrKJLPJNbXBC2+W46V6N5VcXjqLYQfDSZ5q6Et+0bp1UX3AhCZHlfECdj5sNUYz\\\\\\\\\\\\\\\/dcWE28IWnuxk5dHUagYEAHeqei4s2DvvmNAbf4xqr2iY71TIK1vjwuMa4sYdqnADJnt23Z6dQJkrDufEfPuaM3Fiudy+6OhlCkGc\\\\\\\\\\\\\\\/BUeeRuGH7emVVlA++cWKEH3gKWDh\\\\\\\\\\\\\\\/iW3tYP2bbkcJDkiKz9YbuBNFCPO4PGhlZs\\\\\\\\\\\\\\\/jBsE9CPnGa6tHb9UB1fscRfAT6AVT\\\\\\\\\\\\\\\/YFKbT4GNgC82dKOd\\\\\\\\\\\\\\\/LvIdUsIFhsK8xkCFNFml4wB16Bv96MBzaHrd7\\\\\\\\\\\\\\\/PK\\\\\\\\\\\\\\\/tUgCKZrsPeM1OHljbynS7c6iL\\\\\\\\\\\\\\\/OYZyX5m2rSBElRdYLVFc0jQo4JvikrmOvA+A8OLWlqZmDgxUtttpfvp+qlOsKQgFc+7BDmRLXyhSh+6RrsGWYfVzU1rrOjytUIhv3MbusRIgiNnkgM8TIBsLDW\\\\\\\\\\\\\\\/CkQZxqaYAWRcuDaJwssRNgg9e3kmG9P\\\\\\\\\\\\\\\/yryazpa5c5d4wwaF0pOygmysvZp1o1pkijaz9G+SLGivlwbDn9Bh6CQJ1R2DYGnXZSE9vlsuoJ5\\\\\\\\\\\\\\\/JV8QLV9Nm+aN50yEtzvGusOA2gns6gkzUzN5+F9dgFSh0jOj9RKMINS4OTIwTnEmB0M2ksp4EEYGkLqDqiN6NIb\\\\\\\\\\\\\\\/L4yHL97sEzUal3ZzVm\\\\\\\\\\\\\\\/j\\\\\\\\\\\\\\\/n7Bc6MS65jvtrKorFFNAbHYJb5EAfiI2cGXuf\\\\\\\\\\\\\\\/5XS3\\\\\\\\\\\\\\\/9NTWSteU72dec11RawwDypxNIOZmbYoHQW8MuJG\\\\\\\\\\\\\\\/332pSOtKU0zTH9HgfRbNrys3u0bSij44MX3YOWEDrBhHYAPX4xX5eoWmSLwq3j02e54S11YXzAvquiKe4b8sdUHdKAt1EezB1s\\\\\\\\\\\\\\\/rdvv99fowokMeKs3s\\\\\\\\\\\\\\\/yGaeYzC6AvkJEGhr69\\\\\\\\\\\\\\\/buK6zZwctKJw1n3eA70spnWMuCNJkufnxo5nC8\\\\\\\\\\\\\\\/z0HpePu+ozgibJbrJLLvE4TnIDLws823gMD3xMPrZAJideJ6cpcUxoFCK7UOVOjub+OdQQHibiz3QrylreIcfD1IvyunchyIDqLJ7jKQTJW9TuBwlOD3TEkP2ZRAtnUtiNgt3e5qjlNIdAKE8Zz\\\\\\\\\\\\\\\/iFbfWHSccnTUTeXRGHZvbE5lhBizznt4UBhiFApj4ufJNDOMhSohdYZOyV\\\\\\\\\\\\\\\/TbhoFwtsKA8ymoFgQ6VSoTCr5Sx5N\\\\\\\\\\\\\\\/I3ZfU8NJw0AUkfqqGPN7m1fSIK3J9tvTPzPeTzeFyfRxxgXfH9LkL5eV3pTDa4UQB36JrtKv9fNAufb2ondz+WICOqfYLho02uAvDqplEy6QVa+rXb0u\\\\\\\\\\\\\\\/IKshIFuFGxNvAglmL6r3e3XSOswIxs8SNPfNkNrFFdTXSIIFOSacfG7W1UjM7HAu8B4Y+Unvx7s7X\\\\\\\\\\\\\\\/v2HJ+0JFcyufK0e8\\\\\\\\\\\\\\\/M84J\\\\\\\\\\\\\\\/9b0Tcw23J\\\\\\\\\\\\\\\/OAi\\\\\\\\\\\\\\\/eZRdSYHzIQRHqSFfqwA9YQsPC2\\\\\\\\\\\\\\\/i4VyhE6xT6uadnLWwl8AvKHkYy8D8oL60s84H5xag5Mqn\\\\\\\\\\\\\\\/9okEjfbxS998MZbJe8Ccw\\\\\\\\\\\\\\\/j0pEBcAE\\\\\\\\\\\\\\\/whMjfx1xkFtWDD75ifDcgjqWfU4GeAlSgTT2DRjz9TPWWddEtpxRc94XaqejlkCx2I8Cq34sJV+\\\\\\\\\\\\\\\/9Cns9OG6ltQfms5QDi2solqAb1GcOHI6oZ6myXwkggdd4HkQcI7P2n4KL5d0OevKWWyu3QNJdSaR9V5EE3aJfSwb66N5M57CTfuQQD03QjLJBqFtJ\\\\\\\\\\\\\\\/WUgbunhA1UblEXlMUZ4zt2gL9Oeo8rfAIjcivEDgeA8tDdBHB\\\\\\\\\\\\\\\/LRFJ6uRbHTXuAiaH1rQBbhaF8F+GLoFayQwt4Ic3DNoUHA2wcLOBwkWtPPHayHANFpx3vP\\\\\\\\\\\\\\\/jZUnPRqEGP3zHfd8gD0J3q5kGM\\\\\\\\\\\\\\\/Vkv06n492UsDzLhMDFgrCQfizCe8\\\\\\\\\\\\\\\/iF+qF5+Fp1nSOK1zgC5MWk6jpJetzeVtbJOYId5YodDgU3MesPOuqeb4GGTNAXK0ZOQU2tIM\\\\\\\\\\\\\\\/B7iUZXyGhXcq1tnMZohrjkMzhaKCws4kjO2VVO\\\\\\\\\\\\\\\/lGJXMjAp5CxfYMGKFU05T7w+YCJ+H4GFmmsY+Y6a7A1m5\\\\\\\\\\\\\\\/DqiFERiQb8B57Omgjk2rbF\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/jwSWUcNXnwrtG+bp7nKk0iWgiOvpean20063XIVo6T1e5rTbajLWDfg255qMwmswU1nUL5nHmXwJywpHVNgZR23FkxqW6MB+Mn2HCkQHjVA2BC3dFTQBENQt5tkW0hqpCBBK\\\\\\\\\\\\\\\/aGZeUHKQBfZuRpurvmJdtqJT03b+X28fpzYV2iTIOFUUvwt8v39mnJSkQ9sS3np5pcMeFb2rPMGNBoPFCBZMqL2DgGhaPBS8qqdtPtD2VSkeijHbogmAWcwcrQoxgVtBMJ+TU+6f1Qfixy9NJM1pzPzdw0mvBVqHnrdwjliVch6wKStVfZUgETX47wUeyOIG8Iy4looafFgiGP14JqfE+0TKatq5cSmOFxhxrSVo6fFpCQcj\\\\\\\\\\\\\\\/l9sGDXCPXU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cT35ebg7fwH\\\\\\\\\\\\\\\/E8nxx377Jg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220de54db12dfef5a900b8ef6827c784fec3d6f0877fa353060a89babba73f5cb9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/9\\\/e002794add1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/9\\\/e002794add1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/9\\\/e002794add1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002794add1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002794add1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002794add1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}