{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022MFcFqakYlhB3PhCH7rVt5pLGbCLgSx8Q\\\\\\\\\\\\\\\/MKuQTv6nNFpROMnX7arLxCBzvSA0EaxY2oE8O+0KM7G4tvLOh2LPAZh5VUYhuVz\\\\\\\\\\\\\\\/E5QZ03bbxE1o3ub3liCYY2YkFdMQFfs0PZy9UcCzgToXbqPVQfCdAmIvv\\\\\\\\\\\\\\\/np1sl94M45T3KeKFN4Z65NCe4rm+EA\\\\\\\\\\\\\\\/aoY9yMm2GW4kYmEDHaNFAspG3Pyk8N+w+ftiuReuxF86QoQJvvHdA2Yn5UVFlcwy9Yahx3TckEzKe\\\\\\\\\\\\\\\/r11ECHGd5ukAnjgaVPyDQYxlzz968dWsJiybJQDJh6slxijaX\\\\\\\\\\\\\\\/ZbjzRGjXy+Rth0ktJdzSsDcCbKszO0HErK8A5Jg9KU0bcCFy6NncU8mRei69Ot1OHgNmea3LB1aQQzj6DS1wza5Bm6S9OpWxPMXwJSs+dKq800d\\\\\\\\\\\\\\\/BbNSCZdpyreKUYzEdu+\\\\\\\\\\\\\\\/kmda0FOUYZ4nojRzP5mJnay34Jby\\\\\\\\\\\\\\\/XkjJ+yLqMkH2fTU9qiRL2KjWNxG17t8jm+4ilVGWNzNQx7CamujlMAD49iTUdXEDtrV\\\\\\\\\\\\\\\/0Kn0CoM0j1zHjvy0J3ZVjH79VFI8LWi0t\\\\\\\\\\\\\\\/0OKrXr7uE7h9OEBgHPU6jqc9GOmR\\\\\\\\\\\\\\\/Tms2CkvdHMh5L0fbuxjK\\\\\\\\\\\\\\\/ArTaKu3vqiSEa4ijIFovT6mCaORjuH8SJXhrAEPUnCkaOnM7pCjf7IbyJURtOxtK\\\\\\\\\\\\\\\/OElm2xhcKNDgzG3UxutKjIcsqOnRrjip1xLr1\\\\\\\\\\\\\\\/bYPJKmsaLWRe+odQaPN6xPuaqq4lWKMMPUQa1gPDRVaoa\\\\\\\\\\\\\\\/noySPH9KD7oOH5z12Dq1EsxtU+wR+ptwcvhk2AIqKZL7mR6oX7uijhAkidYLxeC9kP+lO25COT0\\\\\\\\\\\\\\\/40DYOCKe4sCgiSBzL+2adEQzy4lrPFVhqow2dZfmkHmLdA7crl9ozJTLWj9m5B6t1bhtwLrqUn9cxSihtTBeor\\\\\\\\\\\\\\\/Rnkd4QSjz3fD8kvhxfZFZyCFvT5bKRWEbFu7ojUSQo82mXu40\\\\\\\\\\\\\\\/BwqbW7B9jbafQD9LMnSy0jEtiyJ63V8UBfOFO1GtVnAdMxbZFTnU1\\\\\\\\\\\\\\\/wuNj9eVgSW7BIbrHjJZh\\\\\\\\\\\\\\\/SYa9rw7sddc8NidBaAw12vSkcwQGGt2btsWEc2l6CUSqz1\\\\\\\\\\\\\\\/at3jYA43Upv+NtFj4M3ZYR1qaF5XNlVtYfQ2kQrjoFVvBC+vM7P+ZNFg\\\\\\\\\\\\\\\/jyeOfg\\\\\\\\\\\\\\\/VOE5lqMsB8OWOHMzCWStgq9eln6Gb0nV3yitBh9X\\\\\\\\\\\\\\\/bjzVuOOvchsgNOxRyQDln4biimANID96PCRgb7imcMCnJWL6Pecj6IK6LWZ0hOG9yveRv60tiIv8sXB4mdI1jHwoA5cHRboG5o\\\\\\\\\\\\\\\/ySrCtXhiu0UPjYEVMM3qWTdAQCwpBfqoBhNHv7fkETJBerDu2QZpxVmKJldeZn7+Pi0Y\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0Y\\\\\\\\\\\\\\\/hgIy6vyVb2Q0xOG+2MNZS2V8r6c5PuXNfoiDJXalOWMIla\\\\\\\\\\\\\\\/G6aK3NUiQk308VySxTw4TsLAEhLvdsIzbxo8bp4IimUvTBXcZx0cPntF9XcZZLykq8V8wsEsdzxC8McjV0C2yonXKSLzVstpV1BRFwVXi55lsoaCUhrJ2iwO9a0yVXzQNeHXXgybnfQpshMgJd3H+5t+vgEp35Eg0CLRbOt4f4+wpsN+RTxXC4KdHyuNebLE6Yq94lSS5ZHS4omGqnhSQ8r9fKg3hhVICmoL4S9\\\\\\\\\\\\\\\/NtqoB9Nl\\\\\\\\\\\\\\\/phcR5kSLW\\\\\\\\\\\\\\\/YoNpV6fn9tS4nshY5Op24caTgC9fGk3FeOQ7UZFSiDUZ4Cv4xCG\\\\\\\\\\\\\\\/Ck7yFhbe6FM25VzJOrZfwvnZrJ4GMnNEnz6ifl8ocYJv9qfjg6jcYWmP4hcSZVV21LUgUZQZA65tzWjl+AUyclQOwglfAh21+Vg6sk+rPZwHFBLAAucGjaWSpRDDQtQFNfvjwQXQgxokYIKcrxYI+KtjzgooQS6uzgpdQppi4QTViLdsjpriBORwgMxQNcxL9LUbrqCV8VIocGg5E3id8UTBuRSBWPKP28HZDhDLPbyLivyeeaHKaF6nOwvHLG2afx6aBOaby3wRFAm4nLc9I3w8axIkHBjwCsaLYU\\\\\\\\\\\\\\\/UcVyseSOmcOziywAo0p0LclKQwMlrvK6Sd8vWOzwqQkWXQW82cDxqLKHjd5F9tHrIJJtMCOFpBqNEirRbnu7Vp6hWqoGOGf5z1yE2MiXTVsjoHltIuIe1z2ZXzAU6pC0PQQwzEeAqEkd7+GevJicIuda826PG2HVZmw4UrqwbZ2pSrkxbZLTT+y4OlgG7GWmgINVsrhBR5JaDrKfBkScSq9r9qFhOmMabBIUkVfwff1NqEVbn7JLebbo6NgehRqMO2kivjcnYvGmfd2lCCeKfx8yzekOUz5aeSgzXaoyp9uyTQZzG0f\\\\\\\\\\\\\\\/smxDuj8f2j\\\\\\\\\\\\\\\/xYzhAK1GP1bRb30Lm0N6R2rWlAa9me843itSfoktxUBSmvWoCy5a1ymKP34Il7DYSpWTy33wTuBDg9mBhkibq0hIfSJ0EZnpFxMxslLqiOyPC00f2sr7cVt2LkPRpD0Bqa4dyPIRwWDRRicVM0VvtqJaBSCzr0mITSrjaiSBKP4ZW2m4YyZcm2YWFvY1jsh7gaI8+LP0x1oU76j8ao9JsN2ugeRqQly0Up0Yd+l\\\\\\\\\\\\\\\/czQNZmwGGSpHmYE88Ag=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022oibJ\\\\\\\\\\\\\\\/8BWMVJ5GIoSx3LtAA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221951e44a89cae9a87ffe594813f362abcc80b2b42350902242e8fe4965b75f92\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e006770.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e006770.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006770\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006770\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006770\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}