{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nrPirWGuodbjVXdY8sKNeH2sV9gsTOW0GhdySUXAEwFTNNhYnYKA7TdbPyRfSwZYup+l71zKdjvFmQtNR2fck3EtS6UB\\\\\\\\\\\\\\\/pMoIW43++KOz\\\\\\\\\\\\\\\/DzTMQPvtlvbvh2eYg2h6HxLhydpx+jXO\\\\\\\\\\\\\\\/4eKYJJ71Lp5+G7vNu9OO9vqxZebe5SpH4yF14U72CyqWJU0FNWjF6dQfjP70JYmZOkIQ0ab4rwTSw6BeI5Nu\\\\\\\\\\\\\\\/MNhikI4O86vT4pXbZS8K8QOFVdJ1XlbRVYGOKbew\\\\\\\\\\\\\\\/OkxLMIZAipepNiXMAw14wBaKnv6YleoO3p3fKzNNUucUMCN1\\\\\\\\\\\\\\\/8D+VvDWkLA16b3Ku+e1OX3Okm+j9brjIXNh1OO\\\\\\\\\\\\\\\/K1T+irv5zJkRLoc3Ahv+HtphwUe3JEjKFirSCoUDaKT\\\\\\\\\\\\\\\/Pju7vQZmnSS80us96Xd2GbRhTdJutvjApkwwIINE\\\\\\\\\\\\\\\/LkoZMnsVFPM+P9xL3QPLOiPH84sKjFS\\\\\\\\\\\\\\\/nRZafFlyZxYotCwQDFAaNQF7XsfMGKA5DJFgwLYp+oVNEL\\\\\\\\\\\\\\\/1ebEUXxs25aiCB6DeHct4+4b9NUgtxQ6v0pUkwoy3fQpdw\\\\\\\\\\\\\\\/mcqYtytyo5Hn8fzOj7luOrLzQBrwKIG8KOA0uoaz0tol48pA70dk5eJVtHRPOBb9\\\\\\\\\\\\\\\/Kvbx\\\\\\\\\\\\\\\/jiojUe8hrhIF1Rczy\\\\\\\\\\\\\\\/UhBtN5FsDmYInI4SIqBf3d1+We+Bf+aTf34VNhw2+gS4qBQYA6OUfdCJ165kZd7UWDrV2x3MFbsmWq4Zm5TXAFc0Q4f3oUsXhTWL\\\\\\\\\\\\\\\/fjdEog1xqzp9q\\\\\\\\\\\\\\\/ud7YPDwFExA4tNaDl7lMeA\\\\\\\\\\\\\\\/CpMFIvVMBfLmQZz1ginc6xG3+KqevHiqV7ZYeQ2Rhrhv2moP4939qXdNU72olCQkE2Cb75GSB2jQ2fEGJacutgROaSIQrQl5op3FouV4eQTb2IUKzBK64dADShZEg\\\\\\\\\\\\\\\/MTgbL9qZV6kEkJQ2zCkRo2hjZEhf3z1mLYrlAZk+QKglE\\\\\\\\\\\\\\\/Xh1mQ+kGTo+ATb\\\\\\\\\\\\\\\/ylem3vhNeJN4Jh\\\\\\\\\\\\\\\/AxdZnVIRFpSLsDfX9lxu7ZbupqFlhkGbbdy5DDKkF4jhsSWJN7XiJ2l6iLj1hTYJbY6g2NCd0+UVMQL+HfjvGPkiK0h9Ye2OoraT+3Hjl0Y6hdeOSlFPxZcyjtPU4oMu85LH+c4SWDvqf4JX7Fx1pzrQh2sLJwsz+OFoAWpOwB83Hb12fRvVlEye4xsoSh88yhJj64q\\\\\\\\\\\\\\\/9XbZDMMJWq8LTbIVnjqtUIHj7GONznVSQfLdM5+MNZpipNTchBSz9uKQiYU1PSYdOEg6M6VNtfXgGHj6\\\\\\\\\\\\\\\/YiDPocA8TeQypdtfO7g4XFeNFmxUyieNmDQ\\\\\\\\\\\\\\\/OwyQhYiuuXevDMNOR5Ah+KChQKGt4704Jx5+x+zN7ImCA7QZJmicWWwKTsoCRiMEyyqLn0g8o0+\\\\\\\\\\\\\\\/qVlpQqnW51sAVHi0MxZjyqduNw2s+9AVPozpm5BzOQEjxAx3ibt0zYHJi4wmNeVrj64SnQ3hyu+s6od3aY8fE7nK0\\\\\\\\\\\\\\\/lXYtE3dtdGo+sMwStoWkKZmhSeOCMtdyJGZnumk38AaTM6igKRfFSqvFfB3ecSr5E8YfDmg3U\\\\\\\\\\\\\\\/14R8FCHreclhB\\\\\\\\\\\\\\\/F+ocgQMpmiWiiVcD2yBXgWH6Lvjc72BG0v3\\\\\\\\\\\\\\\/ytOnZaqkbpQy3wqfc\\\\\\\\\\\\\\\/0Eju5MO3ojuNlDmsrsLBvSPSQpUVPK+VIPMwc5B21SmWAHABjs2e8Ln7SJRUGLce3hMkHK2dpvpl\\\\\\\\\\\\\\\/3g+nwWng\\\\\\\\\\\\\\\/knn18FSxWaCeLTI+sDU56\\\\\\\\\\\\\\\/yapy9TWz4fr9D6UrLlpmphaeZ0BfygXp82T5pMrjoraNiHc1f5e5i\\\\\\\\\\\\\\\/ejmsU0KVzdTB2h5nURVuBo2LHybFio8AsCGTu246iUas9l8+AV+2mzvBFSrUlQcQG4nj9j3I296UAa8JgmAhF2879EFdTdiw0xyresJrQ1H1ufnU3ZGcEsQuXgTLAkBxha9JgnKvu91cLZglVOp+GkOvrDBi4FZMH8PuaJp7209xFLnC\\\\\\\\\\\\\\\/brIrwGwnc5y7AdNQCnwFxhxLoTSpJRSc07FyBhDteEAleGx+hE2ljiw\\\\\\\\\\\\\\\/qDLUSg5cJExteJ5Gl22jrRTH8p+\\\\\\\\\\\\\\\/Zp+zleVHu4HZf6unfgSV4pqomsz3uovL4aV+G7GpjMOK2TQIBdGVaiuR9jdrns8iyf0w85Bb\\\\\\\\\\\\\\\/i7BGzcHrxv9f1M0+cmGiHQHUJZoUXOyQrYFKTEXGNzNNMIYyAWijF\\\\\\\\\\\\\\\/U70OPI1rCEjrFMVEQmcp4O13C9vX1\\\\\\\\\\\\\\\/34nQxCHqCzeRmX1lNWVgIao+FEg6H8\\\\\\\\\\\\\\\/ZbUlHvZs7TJ7WDmk+ftHO3T6O8iWiU\\\\\\\\\\\\\\\/7BViNmLkIDmXAcklnd1k7RtHRlCpKQhJKj1dkLvoGObJ8GKp+lFBj4rjzadrFcQ01yZzKe8GSw9r3m60RMc1LVItb1Gaib4yuRwIEj0cPF9ZAth\\\\\\\\\\\\\\\/e3XJLM5F4EzxEvBvrisClbJoFshNgC7JbaXK2y3zjFq+YnxI1lf0xfsmDDP\\\\\\\\\\\\\\\/OjCIaylSTMqrL9F2qhK\\\\\\\\\\\\\\\/NjWDHoHzF6BOituwc5wrzSEnzYsqv7W2iGoHRxd8rrKXcomi8VXmPiPVnjIiaMUSqKOaCPbb3Dhw6ZpZtAOmVqlsKZSrJD6A5Jj9hAnuPBV4XNY0x0USNHGl\\\\\\\\\\\\\\\/JvC1xNj6yd7PG8jj0jjlopvevdhgS64=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dj362TfwWU++MdRr38kr6w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ef846751e6f708e3685e495e82cda18a4d3b18fbd75f77d438e0a9bf36dfff58\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e006235.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e006235.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006235\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006235\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006235\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}