{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227EqOG9XkZgbBHOqN+7BMknZ76tBcxX7u8xjqaUTeNbcJeJeltGVAaCJheVI1uBqe\\\\\\\\\\\\\\\/Zk6fKPecidzRUWWJm9b8km8YiqO2q31PFn2vdk7YuwsmLetnvMH35LlmPz3+BwnssW7vjfcRr9RJbC5tUbnQaN0tQuO6Ax1yyfb628urFuD0tj5vfu7MgyCueGwoxXxX25Tt69WSh1+8\\\\\\\\\\\\\\\/Tz+thccnQjs2iIzz7qiZMgE\\\\\\\\\\\\\\\/sJXZTwsjz1rws5UDkK6J94tFELuTXyB79bosASMVs\\\\\\\\\\\\\\\/L1nzcD7Z0A6moWakfl2GJJG3HLa7OkeENn77F7dRbKZtUN86i0wp6hAW28jzgw+0eZWhiv0hvLpxsOtEp+N9y2ILnv1p93\\\\\\\\\\\\\\\/Cuimgqk6\\\\\\\\\\\\\\\/9NzqLqfZs4p00aAL8VVNdi7ZNmyv2YI\\\\\\\\\\\\\\\/ijffJ4dMqYs3Qd1\\\\\\\\\\\\\\\/s9T+owamKd1akIAKq5XcQSKQDbM+vLjBNeTITZ2WJsHJHmRYk05BRExehv38I5z92EPKU7cmtcAlki+quM1wwI7ge98OdwI842KFkM1PvfTWPAFhyLRIrZU7gmNeZHCG6YpRAApO\\\\\\\\\\\\\\\/5Qkb093d8UwuIB7d1NiNkWkRE0y1Gzy5gu+CY44qbD3tQPFD1tgp\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/S+np17ij0PVffPLq7\\\\\\\\\\\\\\\/6wPv6PUSTVcLHT1LOe9lB1hqDcVZadSkNtqWlvxxhmdYXDpir77fL9GXT5qTCVtRaiHwYYIIy4A+qKTvLlii05s0BJ1h6IfewOwBJ5JCBXf3GfYlwmybGUYqxeXs3NC8FzGkxrHyAPlfHeY1rhu+hzbwFIIuLasboVRVMoOpQvGpxXTHW2Rx\\\\\\\\\\\\\\\/jC7yJjnrM5qjjHkSrD9uqaS\\\\\\\\\\\\\\\/IPpZ5K8dYx+fwe3vm756ET6QWRyIR9QIja+SXwMtGhzTxKRrWMwXyXWo3aGLUWLNwP8rUJsNEIAyOZX\\\\\\\\\\\\\\\/yLV8olphAkJFZ5lL5CH\\\\\\\\\\\\\\\/5IOarzdGYNs5ibhwzUoHfkN9+YIirGJtk8bGm8SGL32SA3ZVTTPHqIWJV2XaAW9G1hi1bhQON0SwQ8PuePJIMCy7iqjEZQ7PqxzqOnCoghjNSDMZ7CsaXlJvnc3t\\\\\\\\\\\\\\\/Um+xNZMjv8ETpRwRRdZyAqOfIeIs3nN7vk7Zl8xZ2kImIAGZTAmqddym5ppbU0aTv27zvO7IFxV3oMAA9AKqjwTGqgZ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/71Cng3H2ROI64\\\\\\\\\\\\\\\/JPQ7++PsR4LzpLr56lHEE7SDCnvgNM6CyF2AjyQjOxmqNDeTwJRpaTciCIHNilPmYC0\\\\\\\\\\\\\\\/3GuRVmoWgvQzUkhXggrGdS17kPj5CNJoGWf8pfbO+5l++W7A9cAdpO3ykHMkcZB0BrCMGOPZ85j4A2J6TiwgPp\\\\\\\\\\\\\\\/z6wPIa4HdCG5hWwFo1a6OK8cBK\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/NaqJdW+iTUlejm918MPrfA8u54arqKKCDd+PdY4yTogHd+JEdmfzY8eNTimN0JARG84COQSkehr0AuzxH8957BZq5ZTV0H6gFseGSbATb\\\\\\\\\\\\\\\/DwlUBFJDHon0SmeenTn3SoN3S1RMD8t3x2r8dF9oPSTTl1UG1gQhKlGq8bgx+Met5Q\\\\\\\\\\\\\\\/FWg7Xv00nQ5aLBDRSqqB8L40c\\\\\\\\\\\\\\\/lOgUoVMngpGLHuoNSkLxv4195RcmC0aOLTjykNqT5FoLXYKbq5DJ4mYYM+wYe4JVNnBawF6QZd2sfrH6N0NrySNRpKKMUHbOS3YFgGlk33OqZOeGxuwxXxZQBjr3MpqqxK+8wxmyREI81kqNudOP7K\\\\\\\\\\\\\\\/1uWirS6h95qLuPUOcXx+Ny1ceaV2y\\\\\\\\\\\\\\\/FU+ONAsR71oERWphbD0EpZlVwNUtEGiKxK0AR0BSa+PY7c3SaTsVP1NcRIha747pXqgwna\\\\\\\\\\\\\\\/fPrmN0LH5ZYKWLuu3EuAYIBylrFPGcvM95AjnHeoxtnU+Du4wOIS\\\\\\\\\\\\\\\/xxlk6PULrqWFoILDSV+lXxg9xgBlBefHSuyPK7cniq6U8zl3ZZXoHUyQx8Bf2b4QMP9eM\\\\\\\\\\\\\\\/KRZNQRssx8DVFbAvKUuHmsl5yblI5LvHjfFlCh9Lc9TH8c71yMpJl3L4IiWAcd7BcEpTU3TPoR0CMCjthaLn8JsTH6BL5y8zJKAG\\\\\\\\\\\\\\\/+HzOLNcVYWyvwjnTdG\\\\\\\\\\\\\\\/SA2FSZSBMBuqA6Ii9fcV2ZA6ygc+jjbKWt81QnNQeFvt3\\\\\\\\\\\\\\\/CUVQxmTIW+w07z3A7lAgqpaeyUOrWSauGhEPlJAVlTlLTU3kFRSXsvKsZdmi9UBhYrdJaRz3ULdOVawmJkNH5e5Bxebpn1JInMvy4pEGl+f6lukiP6P0HD4wddRx7TgkIlJs4QZMV8FkOI2xOQeVWPce+540\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/acRRnnQHPK8Nt6R93Tm73z\\\\\\\\\\\\\\\/vp9jdvATF5PIJyvE5HH3b9tIaxU1NVvmDI33Yw7TtbLe6NfhSCdzXYt6+fSzFzFZ29RYMHNvm\\\\\\\\\\\\\\\/fEX8VIEHgpk4qT+SfHJGD+93AB8h8fDNtHbrur9+nAS5s7whDgfEXcCJ0VHwDWlC5Q43xdGHvlSAw44pR9fv3r3Xqb0RRw52G4YAnyiI5PLcsk8d8ryD86jKbvbjj8ELy6Q1Vnbd34hGcLU5zj79i60AhXIAlYnbbUNFlGt8xqRFE78IKy6qpdan9tRY5o8DdaKxSNesEFLFXxEwxlcuN\\\\\\\\\\\\\\\/lKoh5xmwqaCfKfjhVmzgn6+hU991iv3xMAamc4M=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224rsyRg8Lhu\\\\\\\\\\\\\\\/GtPCZ0xeyaQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022da46ba5e6f5ba3c7cd1f5f513a828bd35807b09d1ca550b1fa0f5f9f76460829\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e007440.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e007440.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007440\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007440\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007440\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}