{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ewwJn\\\\\\\\\\\\\\\/V1gjmeUobjaDhc8shl1WaP5mEDFj8\\\\\\\\\\\\\\\/UGCem4FPziNi9W16ISB52AZn1UMfT8n7MvLgY1oPvrIQyzTRLEozvcGIHeMo6zF3QNVjBFETzFZGx1dXYAF59aebpUMMnEzS05BKRzbJExNLEFQU7+eg0D32YidRx4iTUoXzzgEZ2WB\\\\\\\\\\\\\\\/fwdv3kC10nI2ytDuGlhXXMvsv2q\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/tN1VJ9LuD\\\\\\\\\\\\\\\/ExfJk5eXozZnW8aOWyS5s2QkrF9u+4TngCPqhcvbuxRjaIY2cargsvlLODEI\\\\\\\\\\\\\\\/DQLvteLtlxfCCwKHT3fwktoTShUQ2Dw2dEmp1OHF6kwJZEClApLQPlfHTE1dwLBlrw9eiDAxVyUzebtV9EQ1K9q+udBJonv8\\\\\\\\\\\\\\\/Mnvk14xUBElUZfiuZvjNXoxKtfaCZZldZ5WJe+9miarDas6C6ryvCROmrbJplzU\\\\\\\\\\\\\\\/hFN4UlUyA0Uwej5UUh3NaGT2wirvKShLpSE1eerl9r7yGciCgzbhqobwON4lpBXu1i2tO0XyTk2ZAz7hs1XKvJag1XKwBEBpYdjRF2PmkS7UhRwkmrhzYQRYEzE8yESsAXeGXX5ifBWBxt8HZNf\\\\\\\\\\\\\\\/w7dWj5Exl30mIARzvBM3imx2bSSYemPXkV7\\\\\\\\\\\\\\\/tMwWm5KXIHbHY\\\\\\\\\\\\\\\/AAf4e40LC0Do89u93dNY471LeigBEuJ+q1A0qBpycr1PDwnilivjwqMPtECxBmP1F2f1ujQKXlBPmFDR7o9p5HaCjrDqry85e9eq\\\\\\\\\\\\\\\/zgGUL2s7DZ2sMs7kP8Ek2XUsH4GXn8Bp4p8HO9UmupfyCMI0bonkFBZi6Y+pemIYkWNhKS47jTmj6\\\\\\\\\\\\\\\/dSbzKalKoCvowJjwtqcxUPoUbB0vZ5Pym+86ruS\\\\\\\\\\\\\\\/v40+y02\\\\\\\\\\\\\\\/gddma5QiC7GtH\\\\\\\\\\\\\\\/xNQUneKxW827MBt+v83KwS3Zvr0ilQr6j3sl7c4Kpz\\\\\\\\\\\\\\\/SKSjEYCvrjNt6xHPXxhurRA7t1M9znE4KmDVN7boyXvT5MQzvwzzFyYpKhGLj+FXa+UAUi9mKkXnEDiLQfV8iFxCyWez87bXl3AaqSqjUtlTlkfAvdWR2ibZAZ718Z8LaZIsTJYBoEB8ft026tq9HpdrfFqh0MsmHmHIlR8a95WWnQFr1++FMD8hWM2eOgANLgiy0lATbcNrlIWC0av5j5zHD1hZQdOiwqyxxZxZCXDHKvSdpdU9Qwmyw62tm+leALoMt785c6mRKuwxR4Cqg0a+pIwEMhuPFCEKUgsSKcH6Ks1TXzJmuy1oHW4AJVxr3TV+\\\\\\\\\\\\\\\/ClJ2PPjIvVpQ60VTSe7Nttl\\\\\\\\\\\\\\\/LYHh1jZ8zUHfgghB4LsxciKBzjfD9uyjukfEpvt1uQTh4JPaQYEdeH8Enukg3rNj6xa2I1\\\\\\\\\\\\\\\/r87OLoTEQ0t6CEVAKkDeY4bcmcNVO0X1nRQZXCJT9F8pSPrOttHbiyEB7pvH3aJl0D4GPVAxDkGx5KeZEckn3E5Y1yLb6ioBlIREtk8k9klL9EOiBAdrOHr35ykJsFsvA4nYdhPWfMG9frDjO0LSkw0eN4Jrinexudrmr5FDj2FCkrX+QBaBjy1dng\\\\\\\\\\\\\\\/bLbCRmtydKIOtSq11xBzvfDO+wmfH0eoeROZli\\\\\\\\\\\\\\\/ZlznD9xaRseld7MQyTYhLIzS8CVoTm9KmTBP0AGW2c+hiQFm0o6XhT5Fcod+kjdWEp+OMsYG1LcqxhF64f+YFy0JiJ1nbLPJQbrMM1YxiBmj2+b1MRNuZSzcfTEYJeDDfVFUnKhhHZLwMdwbwVowNceekQbQYFWW3auXegVKPqAL\\\\\\\\\\\\\\\/J+1MqZBTlnoVyyfaRxPO4zsjTgMTmcyO0dTFBUjeOm0B48gwKb8qrelKaOIWPYs4ModkZYGb8euwU2\\\\\\\\\\\\\\\/Gjke6KpdVjFubUICUqHKTRF9YuobSOiK5L5AhQyq+MTpHP\\\\\\\\\\\\\\\/wO2iNeQoR2Yt3UGvFYM4bFWCeuxUEwyMFM\\\\\\\\\\\\\\\/ZOknHANfJzw2x8vX0crDoNDL6d\\\\\\\\\\\\\\\/IF1TyU6Z78THzCzKCntq9kYLT1m4u5JoO9hIym00s\\\\\\\\\\\\\\\/2qgJV3fh2feHgSpGjlMqicmUh\\\\\\\\\\\\\\\/FHRdQuaDuQrdPtp+U6ToSGFwhw13vBwvXzimxgfuTV0XjeehfuqPk90+Pez57IGevIQKuSYvroDPAF9wA+Iz+M\\\\\\\\\\\\\\\/MqPRKi8O2D+LHprBK4eefbNZEGczwj3jCPa2J1+QfBlhzR8J2rzTGyL8+PoYBjYs4PvKd5QZrBogv7hVANEqiQusD9V3Z\\\\\\\\\\\\\\\/BkCHn3OIQ9qORKFuk+WXWl8YYA0KSZWb5kV\\\\\\\\\\\\\\\/SBkGN4cSoyG8o0u7IlObXhfYpjOJaCGI\\\\\\\\\\\\\\\/XSYD0WcuK81WGzdl6uwzUnKS9Ucng2ef9BLs7L45bM3IeaYl8RSdF9ZRAUwGtBw25rnmFXLOGImMcTHoB72vjY70zaHXry5r4ljkdADdQ7MwfiJ74HY68G\\\\\\\\\\\\\\\/6LEH8hEo6Ai\\\\\\\\\\\\\\\/cw2HM2il55t8uBuAYqd+E54kfWT6OZwroF\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/2YHY130eSpmtMn2pV8kGzuTvKIVZZYJKnFd753QcKID2g12zKqcRDVyt\\\\\\\\\\\\\\\/PxWYBpdY6u6M5mA8aBZK1Fr90xB1ftkvq11ZB\\\\\\\\\\\\\\\/9UNKtUp3Gqsx9SBxtvDygcVT+5essbgdU7DssbLLIUXiituUodY+Os+L8Wqi+3on5KZknaJ4o7GLGNRmF9TnGlG1CljheqF4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022c3qPcI36qea9U2U+B3GcmQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c2fa0c72e60e84f153f4e54ca1080114528fc1166825e965c19c9b17d138c709\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e006608.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e006608.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006608\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006608\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006608\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}