{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022TY\\\\\\\\\\\\\\\/3Ig2h6P1bW1wRmD9kJgpm2yQUV8CZgSNfj9DI0W75GLh8k6YOiOkxIAUlfKNQqDUo5y6\\\\\\\\\\\\\\\/yx08ppZi9xS9Acl7XdxiN640kqL0rFWBwtKut72EYdc2GcGEq+Hpi5fJjjmQb9JFf+sXSvMYYQMkehrtWtV5SjlHkL0MINOvrnHt5\\\\\\\\\\\\\\\/LrYqUOWoYtwDEEAD1w3T3kxTcJEyiIgRmRv9Z606X5jui1+J\\\\\\\\\\\\\\\/iDUTw0lrVlurn7pvz+VLh5BxixvvOV79lgKdxALILhAehomsg5qZUOJWQnh9jh1TxJO2PFzTB7i34bk0zIQFTCI+NNwLYJ5\\\\\\\\\\\\\\\/DPGor2lpWxDfggzfh5pVy9JX3ZgRYOVjq7ojmirbEcH2KcH2IRdK1Hlr2GyfyJ2+wS\\\\\\\\\\\\\\\/fNuVQbkhlOeqUP4wiIni6fPZeH3Wxk+CCnanQV3VC0ErB0yQE4DyI7EkaBR\\\\\\\\\\\\\\\/lXPuGB16Y+H8e7Oc9DPOBL067Y1oyhYunUctGtCd2weK0eT9MNqmYfPOU8HMbBCVQCPVObR0OFLBlzUxMNiUHsxq\\\\\\\\\\\\\\\/BNSp2DIJpRrWcUow8nPTTE87NoeXGd8GbQsli3Z790BYwNxXuRgkkmlyk\\\\\\\\\\\\\\\/Zm5axO2PuBmA9CWYXfWJzqSrTRBmebv4aoOR9seHGdhEKjUNJsTvnCgNGX+\\\\\\\\\\\\\\\/Hm7e+dtQNnlcagHiV4Yhzv1ZljiYDT5qxO3oz8L\\\\\\\\\\\\\\\/13DXEJDhtAIzLqBM2kdr5Z1xoH0vH1b2N+iw75vBe6DwQJhnUkpmzbLCTPNJPBQSIR9QUg2hqKfaIuYxoGMRP\\\\\\\\\\\\\\\/swZmY2tvC6nGTGUC9uBjTCIYi0Vjr\\\\\\\\\\\\\\\/KFQlqgHIBB1NcuqK0zqT5aulVOfMlqFFtH6h74tFcDTbkTokYr9HpmjzbSOvRf0uPb9sP2tdnkuWxXEgFuegzH9Q7zTfXqj8v9TUarTWliFyNk8lj5PCNoFR8HDaQq1\\\\\\\\\\\\\\\/1qr4i8HIbNbQdmgTMsa3xZOB1ACjOkgL5aLwNLljXfo63b0eBpjFuuME16H27NZsP42InFttfP6yjeY4yWYqOJfmQI1Sw2n1OhFyLujz16AITPaieoT9Fpq37luUH+hF8qctIXP1geSX7Jw4Ex5+\\\\\\\\\\\\\\\/Y9tnjviEHwZM6RFQGSh242kkIBEv4bBE1OiXIWNTyexVhNawtgipY24VqQPEchNg3cd23C\\\\\\\\\\\\\\\/oaPjdtC9xFYhyQhXBVgiYRG2\\\\\\\\\\\\\\\/uQ2DVduGEZ4nbtmRYq\\\\\\\\\\\\\\\/fQRjTffe4FjEvjoyV9u1adXGa9U1LB0PbblnmujRxUTQPCcejMA2PnuaSOyf985cxxGnJ8QyuSm5yqUt0FxfiQhKEJVUA9nXyWfF5yeLYDd8XVPNqDtDu7MLRrPfoTK6LmwBrhMDhBTx2uYdkO2sZ\\\\\\\\\\\\\\\/zx5LZ\\\\\\\\\\\\\\\/r+JnYPCyL9Vwe0GoFSv2V9Nl5+o9hoGEzusGMnPHyqu5DzBSah9kwt20GyrSKHIX8ET6fpkSZvANrQwjZz2g5\\\\\\\\\\\\\\\/nUpuKVjlG3xw2Qxlti5lamCaX4HyftXUQ2l8VlR9wQl+VFtVOX\\\\\\\\\\\\\\\/wsEMwBoJ\\\\\\\\\\\\\\\/Dkmj6+1xRyEm7gI8ZnMD0ta3Kxnv2VjrJdPwOsoP2a1apntmAHJgSS\\\\\\\\\\\\\\\/oEP\\\\\\\\\\\\\\\/K3jQW6v9MsDqDNAIL\\\\\\\\\\\\\\\/+lHCQ4BOkbFskks0Hy8r9radskB45sVbIcz07FXS27Fq6dTwvXeFkFEBx9MPmG6GgBxgdOu8zjPQ0pTTb4Cma69YpxrAM7sxtyXPpyjiEuquDJ8MJj143vq91vYcc0NvExuuqUSkkysPp03aNpqbVw4yH0lUd\\\\\\\\\\\\\\\/C3PGaigm6lfNsTRmRbVvrtFdsNtW0ON4iJ54EfzefdCNglLeeUAHc+sjduoLjYzVGy4PKKHRxKsPtSGJTH\\\\\\\\\\\\\\\/YmMJBX0K6GZnaj+59IDcls13NCrVgwXgkSRmMQ5vUWCAvIUmK+La40n3hu1e5EMGcRyZlJQw4fO2pOzizZguV9RixW8vyU9UDO2cimFDmFMV66X9NfnpqhtHnnOBFNBIu2tIn7zAzuJEeF9KWmbgxM+0oot3\\\\\\\\\\\\\\\/HfVCoi4MQ3PZIEwCHveiP2cSS27pcJHZUnWHeZuz2miS0stu77\\\\\\\\\\\\\\\/vKPnrj7vPnHYzc8nuuiDffYwNBI\\\\\\\\\\\\\\\/F+8r3+tO37hest6p18JBEaKZqEe8px\\\\\\\\\\\\\\\/exN0iBHAIYoYjpMrVo0JkiZR4Q4QvoDNPAb2FAtekW8HuY2wwU+\\\\\\\\\\\\\\\/eyyPRDKBvsd92ELYGIfZaKI0Ov3OYQvTIvcEiaePpl8rYmHO82Kp\\\\\\\\\\\\\\\/tAMjFdbPmBJ7Y2DbW2imOd0ZMJ34P9+rMevG0JXlJuxM5aMe9KQDAov8lw41QkD+HEjyQOkUwSQXFwCJVnTYPwhNZlSffa\\\\\\\\\\\\\\\/VjcdzjL226IYPsS9IXvJ7bk\\\\\\\\\\\\\\\/fVcdfLLP6HBWSV4fPNyfS18hgYnLNLvWuRhfh8lwZUTkWPnuTWI9sEbleo5O+oYeJRTKOQYsElQMgIsUncgPl7q58MGHrqdUYxIlQ+5Kq8jXeLYgOlbJiopV5qPR1ZffVCHNV2L5IhIpdk+Cp6oNbA9tH1aCTv692HkiMeFRhExbac4DbLbKF7moJbkht8m+PxZ27BdO56ZCc8wAt2GJwIK3slCpDBk8QNe3x9dPZqYbZMP9Ho5sbpsdLKBUob9o8npD05KxbPuRIQ7X+tzeJ\\\\\\\\\\\\\\\/76tlkZtXqRlOo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Ofw8e0XNvk5tnL3pcmFc8w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224cc32ce9ff5fb69baa15f45d1be8d127c3e4daad8ba34ae5c7cc75f9f21c2eba\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e007023.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e007023.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007023\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007023\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007023\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}