{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CsjbQsnjyGPJFveAC8MHhYYlfWpzWLtfPpUo3HandOnoya94Q2WnC2ofMeSBjWjUsMDk+gTKrNRRYwESxfKmCF876TjhpLwLAxr1VMmIbXQVMo0Qk0JO4PeyzzltcxkvL2p3uGJUIwWMb9E8OZpRO\\\\\\\\\\\\\\\/xtoTo4q\\\\\\\\\\\\\\\/mqRNfMtbsRWO8AGbKf64DhEf4QjLAXiVgW7eofvQluqq7oV7dtSul6PR4lMIixtWPip34xLLjNBT3cC5jKqiPJzppbtP\\\\\\\\\\\\\\\/1i3sDcKboWC1ZbR97jC\\\\\\\\\\\\\\\/esBYHWXYbSNpbNUHlC4Awy+lx0yb\\\\\\\\\\\\\\\/v6fMk6G\\\\\\\\\\\\\\\/p+iHNdaj2RrtJEyfBPUz9vf3V4sJ8vyLnvkHO84ob4YNJ+sPBNpAA\\\\\\\\\\\\\\\/OqLY3iSDXz9\\\\\\\\\\\\\\\/7shpNIClWfoSSaqXjU6K0oxQ+tKvkx9xSsAMugxZk1cJnzyMoHaZQY1nny+60pwWZysm9BhianQe3Nox43Mwwd+jzGE+WCJ8+nt4UnmUdgGy\\\\\\\\\\\\\\\/2PL0o+EXpIVbF3JiVrhxnT8RPQLpkdkxjavV1zT3JYpvvQpx0ZL1VoNfeAfgU688ld+nNYVPCEr7X8Ra6ldaKAlMFC3WTLQl7Q6Ua7e0ChzMVF+bKtpVBj20P7P37QLTrbdgtPfeTvLjTPbxfTbBOx7NUqjMF+\\\\\\\\\\\\\\\/zvvuiwylTOhbxHt4uxgKJPBEWMh5r6HMMUw4+6zPKYlEK0nuE4co2MX3S8B1mu43NHoM2plq1QCfjUdsDvDKry1FeWL77AtsCItdaWqE90SuIj5eh6IxFdbBE1KQkG24l+BQTW7hq2vdbk7C4R3r9lc\\\\\\\\\\\\\\\/Le186NlIVa+Du\\\\\\\\\\\\\\\/iKWE0\\\\\\\\\\\\\\\/o1hEFcFLglRLbwYfiiRboPZdRm2GqH7uHwpztz05TRMvryX6o\\\\\\\\\\\\\\\/gjQhPwncqQTbRXsrnmnJdRIaC24uA9g9Tzqw7cgLhsOxZQ6mjusdthKpnb8vHcxJoh2zhQEXYPwZMBQufvjqSt0jOw1TKphr5wH3cc8Ay7+k1P4uQf6Yjg\\\\\\\\\\\\\\\/xQie45stKhc5kazGCmJcNeSXILbIQGLAR3VhKVXsWsjMQvhkUTxX5xt3UYos0ubi2KImbZo+MflBsMSJD8n+pd\\\\\\\\\\\\\\\/HQfCx8oVZMwETWmENkRi8b2NCyAYQj0V\\\\\\\\\\\\\\\/vbiFfKj\\\\\\\\\\\\\\\/+gZ70RLKAQXmjiCfGoR7gP1ASUX3\\\\\\\\\\\\\\\/ZWHMKi0Hunt2as+Rmsvm8bYvrapEgk8OpDggLcbjG\\\\\\\\\\\\\\\/k+IwMg63PatOlDPNyuPK74IhEs+XEAI0HWMbK7JckSn41z9ZkVFtLTyZTPl7oO6TdlsY4brZ4Ozq5Manl3Zmf5nJrgn\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/AV\\\\\\\\\\\\\\\/PEb6v+vTgL\\\\\\\\\\\\\\\/t1l9sTIicr54tvp0A0vhf+MVAJbWDJflqJVOS8d6OHK62qbAeKA2xl8okczuyXU1f6ZjyR\\\\\\\\\\\\\\\/khYB3\\\\\\\\\\\\\\\/c9WzYGSbcn2fUPVi7OiopdTyuYtA1NYeovr8fDbx+RGQj0EXs0Rf3DodrTmngDo+TK0yrK+QjbcKCfZTQYeH\\\\\\\\\\\\\\\/u+gyau298P40W1zaueDk+5Cd3b1Wu2dTChmJo+VBbfVLnFPM0RDK99k9f2DmaxxfbX1me1\\\\\\\\\\\\\\\/E9GZQnLuDVs2JBigTACEF564r+0iR\\\\\\\\\\\\\\\/Au\\\\\\\\\\\\\\\/49XX9Mnq2g7JpCIlW0M23O6k959RUwqeweo6CdL0\\\\\\\\\\\\\\\/OD4QVc186A6zRA9jbv2wQ1FO8MfTG9cVw8NjnsQBfujiB37d5GlX1fSzdZMtLuw9qA6QdVHCbU1j47OCuEjvuVIlE3XaM93PUqQweldL1oDkOfL+fnsCAj2XkUcSi\\\\\\\\\\\\\\\/qy+7\\\\\\\\\\\\\\\/wLLpfT3dFblbIWjqjsDdwm6ylUel12gwYwzkuWZWeSODO+Oyx\\\\\\\\\\\\\\\/4gi+WWcK6E6LjB5ihYsRW9KG6eFPZO2rGmYW5wqK1QPlUGcfdSpo4A\\\\\\\\\\\\\\\/yhWVQBjs9MgVG0l7SkhG4hfqJOiaPUkK6djQ6bMYrfVY\\\\\\\\\\\\\\\/AKYCnyk4C+mQAIOruc41KLqbbRNqMJm6giCB1fmcJw55zkgInwJ2jgR\\\\\\\\\\\\\\\/bcttahjIP3oRNlYpGJE8dgkMG7728uYLiNVafVlPGbGNbSrD0rytRzEKKREXQbqCQhqNpcFPQqSOp43y4h98U3jksh4At\\\\\\\\\\\\\\\/34W7f\\\\\\\\\\\\\\\/FcsDoM1Ki+P6Ejexe4J0cpxOWETR3FeBsYfhxPeyHyA839DxHZymXdDzfYeaJwPbOc+VTTEy71wTVnNTDl5dWJNE8AWd8c7wHPYPqg26yAQlLBRZvRvuzAJKJeLq5p4rPYHN\\\\\\\\\\\\\\\/yGFb\\\\\\\\\\\\\\\/FULKrHbp72qB1hgNfuBILsaAuplrSm\\\\\\\\\\\\\\\/WM5\\\\\\\\\\\\\\\/IecgPaRkUqVuV8AhB77Cr\\\\\\\\\\\\\\\/cWTlNXpy7Ad\\\\\\\\\\\\\\\/DSJGNRqEQIdh+1FsgCFoUitZT3D2RoW6zzQ\\\\\\\\\\\\\\\/Jy\\\\\\\\\\\\\\\/yhY4GABCVTU5hzqlmsvjEpKuKSklMEqKwc39LGbakROzCBUGwvtahwMCmACoDMaGnET1hD6Al27ZPSba1wrhFqW6kqNnkeynrCgZ4ZtxU2fjHexcaCQJP7hIAD4K39ZonrlIk4P34BqaTKmeLbY9QQiiLTspS+OUbJ3QKUX\\\\\\\\\\\\\\\/SNmgHQd3BTDvweYOIqOU2yeGVGQ+MbXhZrk6cCheIxIXQbFHMc1By7XFgHFm8dH5vJ8e+PyccNoU4iqCf2ssVWBWDtnOiwOGr1ZXELvSazVdVHso4N5UEMq4XyGSfVV30FJLS944ngZwb\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/aEbWae1MlvgM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022TPCQtImWm6i28i1ZR1P19g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d11a968dc4e1eafc1643657b32e08b378a6ef2a3fbf582ac364a98e17eb94b6b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/8\\\/e007070.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/8\\\/e007070.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007070\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007070\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007070\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}