{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PyMtyPHtyw7EUHOEgqUWCVIR5qEI5+lE5MfoPv+XRfQPq7lFXdL\\\\\\\\\\\\\\\/vk6vGXjDa3x1duv7oEJaWThH8gsYtsbzXyYv7mUzj13U+iMo1KPjwUFfl8B7tZ+Q2mxTDsxo5EP5oPGxkgmzmUlwgzLS0j4wFSznvqdXzIcUDt9QP69E42aAKz1PQp4K4YCVRVXH\\\\\\\\\\\\\\\/7uR8+wc\\\\\\\\\\\\\\\/qBL4LdqPLRTKwFPPK9V5KiAGUYecwZpWRqbcFOyfMgh97+oKVBDrv8WRxeqaAO1zt1qj07X8XRxhOhCYIYBri4dM\\\\\\\\\\\\\\\/QBUBkuapds8WARngKRbriS2fKxB24TNYM7+Mp2Xu8i7x5Sec0XYiFV0QAn5JBdnOftFMYa4A\\\\\\\\\\\\\\\/XD3zGiNFZJ8x3+6CYLsOaONnaZTlOPRO3AwSUcHp9SDREkQtggmwcmVjchXEqWoeKFn\\\\\\\\\\\\\\\/1o8VHunJFrpBnMCzPa0sh+lfWZEWlU04kYsJEHGkHEwRLn6YXu0wg9q6kgled8HVif3GTnc3j0dqFYS+Qp6YbWi\\\\\\\\\\\\\\\/6OhfNXXeppW\\\\\\\\\\\\\\\/CW\\\\\\\\\\\\\\\/S8s50ogUoZNgQTV0TzUrOwDCjabNtHAl6ptJqGwf8aCvzPnwMKPbrSqFKhYMprENSbisBk7bMoW3WlkPIOZ9kfBPko3Yh24m8WlTu5isw3AgS9rGn\\\\\\\\\\\\\\\/x7ddyG6yANEr35CyEVOC2\\\\\\\\\\\\\\\/iCm39VDv+cugHfis3+Ap2vGuUVr\\\\\\\\\\\\\\\/2b4pKToLXLG52c+EvvnrGRiCMCWh1bTezsYjtRvtyOEx0JQnmeoo1u7SSuVQ\\\\\\\\\\\\\\\/3Siv7ZzptWvntfthJ0fNLF9Pj\\\\\\\\\\\\\\\/LdYZfB3bOUbrA+UEn1fOP3b6qqb9Tc\\\\\\\\\\\\\\\/+gLfX89ed\\\\\\\\\\\\\\\/B1yRNHAXGCefnd8gta3qUQecfc6BqFzgFGnm4DuWhl3lQUeJ\\\\\\\\\\\\\\\/DhPxiR5yfBjlbYCXRxxDARqdBVWdP2J3p9uZJ+IJWcRCspewdLlNeCUWzkSUbAH410ZHPXoal1p1HKrfvYDlgipmoGWyzramBxBhdqN5T9oqyiX9cWAnEsZlJpMYY6QfM2KToD9z7awRsPQQ0NdMKlLB5CKqLEI0pZ2l8jevGjoAKyb+ay9BAmH2yR4sT9ZYYyRFqM9bNwDPYObqj0Tc5JYs1hFSseVLv6waApuAojBE1opvy9G8eCxdTpbrRggMfAJ2v118zO0zpqWc4VmB+J07qkuvVc+f\\\\\\\\\\\\\\\/R1zOrC33BEeFf1giwv1XXR3gac4IezdVN3KLLd4TpOI8o7CyX5m0AB+scBMm3cPWgTG3te1L+x9ynDePG43f2jKMwZ47Txy1RkuSNmsTxoWY7w5YvSLuzlUH4PH0v\\\\\\\\\\\\\\\/OgHD4zSKVyUzM+6RuWX+oG2yUlFTrz\\\\\\\\\\\\\\\/xS9j7PyUVheYbU+3pzlr9AtAz5yLb356fFcrko35yS2P0gK4OK85\\\\\\\\\\\\\\\/V42JdFk9BUffe7c5DSjBZhQjW+F3V7vthJIhuC\\\\\\\\\\\\\\\/FtxJ+W6WAgvNIs5GV3BHPVkN6i4CCeyG2ywUc\\\\\\\\\\\\\\\/LrgRCRUg0s6JTKOx+mPvd7QafnuQ8QrXdeGSkvhcYcrNxqjVbDjSp9kr0aGg3TPQk6opFsa6a04UNVUlGd7kV26Geia48mTyMh+qXlwgfL31hBJqsIAvKLm9FISlUIOvfGJnuMqUeqMtd2sFcOQlBwAQLTPUFs4pGbvNIgT5zupXgtsW2Njl9AuuZorTyVJJCNRfsRlcSO4Op\\\\\\\\\\\\\\\/fkbQAp49CmAQDrVosnhg9ZiCFZ5IZ4eOlLNTeqNT1rzLfz3YCDdGoKLyG5EBuH4Lv8mmEHR4FIWeZG4wDSPvy1sJbbezfi0P7Fsg3iak3g0i0ztD8Ylfhz+BMkPiiVZ4K5pI9Ncpp9CoEqKmf0PjZsP+huFBNGBbnRw3t7BHPjzo7zFvU4u0txt8B+Cya5iECFRpos0+4fGp9+pQUobcfUyxWv2e51XeAH3QyB1aE8V8CgPMgevXsJInH75lTxqrgbEsgBSQh71r8\\\\\\\\\\\\\\\/WNfBbHEMYuRNNUXYD1W9w8BJ4FReqMEz2HsUfuwnd2VmJPyEWetsccNCTkc0wnWRaAHUwzhdwP+6H4YrgYfxcLZYiECqraiYscH0ejXR5UXe4HaSLk7Mk\\\\\\\\\\\\\\\/WJdZYjQoEKxVHqo5Kr0+EBN+G\\\\\\\\\\\\\\\/49vaTQN8U5FhlSXjmQ7+RAy0z\\\\\\\\\\\\\\\/2eG6EvhvSjNayFgA9dOTFnOqzQPi8xdvmB4cigfjJBLbRk\\\\\\\\\\\\\\\/2UpfkIx5SSFXZFfUjXQ1Gkvk2YF626c8Htv3VCDMt3kPa+JnJUsPDDeftcvO5nZdQjY2pFu5zWCyjSmhUK7WI\\\\\\\\\\\\\\\/1zsoqeEE0r\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/9qb6juR88J2ur1rb70QE7yoE3faiPP9fbCwcebO5v1UwVBzRLCQ69gRsHESU9JTHhJGU3nLMWz6hrn14Nupr2PjZwKcib3byQcCePcVeCGrG\\\\\\\\\\\\\\\/og18mxdjoals24sOL+sGO8m4893Gi1m04vFWszQ9RCc5FXTAw0vsUNmz3Rtj+7n1kd8WEQfklCYqX4JNhP6RJL21aXQ+YgJ0r3fRaBDe8y3kWlS33jwFTWMacWeIjGVPzdrrUFBmbOg\\\\\\\\\\\\\\\/jVqNmNdpkBpUT\\\\\\\\\\\\\\\/zP8aPHEsG+sBGG4jrxwLVmaL8TwJgk3yJwfoCHnOKKGjze0SZVelY6FR3PbsPrSBqhcEOvqdUHVDhIPSNDSNVpSb4tTfhrJ+95KTY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223NnZfMFQsrSOJil4ED5wUQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222c3b384f57b53e7e7246afdf1d5259fd5843ba6a305c2df94de1fe50b05e364f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/7\\\/e006348corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/7\\\/e006348corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/7\\\/e006348corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006348corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006348corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006348corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}