{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022yY0rjzGLafycK1J69fhe+68MztmzmP+V592FN5q1yguvjwl22CU1XRhJ7Vdha3+8x7f7\\\\\\\\\\\\\\\/B7fEHbtYh6UFAx5c6bYgcB8e1+503aF\\\\\\\\\\\\\\\/OFV2cUJLhUCcKq2KplxRTUEhrFCegOMzoldm0I+ZxWGgU36v2CBFBUOmBY7sziFvG87YNWGYulO1pY9CcUHLUgpI8j7DTpaXyHKgqHZMtF0QFH7HnYrshqzydIEw\\\\\\\\\\\\\\\/YP1dff0bUqfEjMbnxJqTUtcTLJd0KU2sYoSeSfhBQ66LrUbbR6b0jhwQYWmWkh3lx6tLoPsmiEZ8nXP29cG7AVSP9qkDUJgjYOErKPwCnhL8TosrOd80rwaFWeJ2prBrQaXnPfK0TI7Z0yW2xOTVEhCxBFSvxn4kuTLQ6KyA6QgbY+vRxU7wfE7xQyTfcXVPpiH0MyQBoRti1tYLya9bQ51v865nj00Uyrt41H\\\\\\\\\\\\\\\/e9kRp\\\\\\\\\\\\\\\/m9SkR4C\\\\\\\\\\\\\\\/hCwD8bp1HvyXyIP4CWsQmicGres21j1iVtn0erJdJ87pfTFQGkJCaVtZy6wy3qG+9obgt2LHMBYjNpzCksec2JH7bCotM5wj6WoYuDY0MrKX7YWDPkxaJgNR4LjhwyGlW0+iL03f2oNH5PYznZ0nHQP+mZjpkAunQa0xLnDz\\\\\\\\\\\\\\\/MTT90xl279Jh1riNNze0+uzohN\\\\\\\\\\\\\\\/75TySV2OKm51bXVQ4GD0\\\\\\\\\\\\\\\/FC5+pRmiJdHJB9AIusU7Ftt5+65xPBPcB+AHf\\\\\\\\\\\\\\\/HitYe7W2J3BjnOcFggeLXbPgYDxtwsIy6UMhO+5oihgy1tfM1+aRoG5oA2BayD+OMl7l2nhytDq3v1+L9kVP\\\\\\\\\\\\\\\/SGmhHl1n6ITGBc6An9kyyNGAFkvESdxn2+Jgh3YevlqnnJczoIebD5wlWPVRWrRDMEm+PV0LonTAJ0+qfPcRGmAiOMBGLi\\\\\\\\\\\\\\\/TIJwlTw9jaQaNglWhsNRS7PUER2UY1ln9ArkNNGpFwEwfBEZvAatS0bq9Up5oKxjU\\\\\\\\\\\\\\\/y0lrKgHTrsNzWwrVZcZKgR5FDJpu0WRkvUwEbwTzc3oioBWt6Ra0KGTDbBKMdSJdu4MR0cXw\\\\\\\\\\\\\\\/R6NL3YeLjKIKJV5TVfSqgVWXuf3AseXOHRyz2tHDyGQcTWSoupSgvENaxK\\\\\\\\\\\\\\\/xjajvYBCbcjBk8iHhRgSgcIVWx+q1pkThU32U7xBRMmuLpJEpsMnceyKSZsLplAq3pUHgADtxzDPI9slUrNpaLvm4NqlnHitU5gwbs8sa9ic9zAaF7h35Xj9x707U34tws\\\\\\\\\\\\\\\/H5lI8\\\\\\\\\\\\\\\/UB2gWApwCVgfT91mwCRqAJDagI1zzDg8xGeEar6EAuomete9T4ukHkqrDF42vlv9dTS\\\\\\\\\\\\\\\/ZkTnSejuyBfCXf3NNAlqfxqTY9lppqf6wcSH1sa0hrx3uOroLwKnFnsGeXtum93z+eSgCvjc219qh4iOohs6c36R5nXWxSo3mW9LwCqZ9S2piOJMN8V2aYD80ajM03L3Kt95wdqWcp+xM9szAiLZKi2jVs1zFo3dojTI633wWabF\\\\\\\\\\\\\\\/FUGNPz1CW5SD41Rt2aEddaQ\\\\\\\\\\\\\\\/s+ntScw+mVcLV\\\\\\\\\\\\\\\/Y8u6d6bC2vG6RODxWQlDuVrgFzhklbir3JkMu8HvTZYvX7MPu++9Rq5motO7ouvvR9qB1HfrUIgEsO9Bl7ZjhM7cZZLH9hKc43iX9sjgrkmrJyGuELt+Ajqon6FQKV0xcsupr2U8K6b3QUTpMFA4L0KtTQ65oDwLBI6Cs++FASsAG+lX2Zp8j4fByIm52VXhbYnlNF0\\\\\\\\\\\\\\\/tQ5XcsBG\\\\\\\\\\\\\\\/cHHILGBksKhrodNDrxWu8edNvzlcCTY3Azc9A8xQKEpTupRpTA+WE+NIiHyKO2rCR65nQk3BxZ34uQSqBpfF7\\\\\\\\\\\\\\\/NktDwcDO4jIdk7oqzYRt\\\\\\\\\\\\\\\/KlsQ4IP4uGjTVs0THpwgVFdOmY4zKVqXLCfwWyABbbqKMYq8wTEJ+NEYpXCzpp06YAoNJ\\\\\\\\\\\\\\\/OdCj3PBWwV921Ef6RaDyAeXC8t0EWh4ot5XzcKbaXM+ZWTkwwKthjsi1sxNIop0gks9+ePXpKDzpDGsZ0zkSA9a6B249RXKki+UwBT9Dumi7a\\\\\\\\\\\\\\\/GdfGyc6SXIDsAToSnBsYXZjPZSOz0ERaJ+4AVafuOc2N2u3U5UeRmU7ew6cCEntVtkpuHiMmu3BGHocfgADJzz1i3kQ7BNZ2Ye0OIpO+JqkF\\\\\\\\\\\\\\\/5ecmJRfdOrhsE3Aq+RXd3ihZrUPfNDJmS89p6mqnL7TKmjPEKakYoK3XH0iT2ukbtJTpO+vh62jWqFyPkOhLJgRdfTcglDzzpGWm608JdPa9+iEQ1jSUx+7aONS7m48sc\\\\\\\\\\\\\\\/ISORu4NMT2e+bcLKpnqTHk70P\\\\\\\\\\\\\\\/RixDQvWdPpaow7yTt4JeZ\\\\\\\\\\\\\\\/zFE1uqhFJIK23cbuiX8NpTuc+3oALNl0b1I6YgP5xHxjMZ3A7Bzfg0OopCmhGAiDKnoqs1D55SCu3ldKY\\\\\\\\\\\\\\\/KQWqRP27C6j8XGGIlbwr1sjozlF\\\\\\\\\\\\\\\/Z\\\\\\\\\\\\\\\/8fut1eLsTHgkmxB+rD0nzZmNmlsQ7Nnwo5SBn3a\\\\\\\\\\\\\\\/pX4CLenmP1FOLWnRLkWkhsaujIlPQic72V1VFbFSwGVI1vx1MVdTpo4sHWZEnOtmMGBxELy5Ja4D7DvsopiAouNLxT\\\\\\\\\\\\\\\/XVO71FpBt2Hy7\\\\\\\\\\\\\\\/NRn04SxZSpdkerofqGtN7okwPnlI82LGhlZyxTKpiYo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xW6Z0+0HVUhNira0SjIdEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227880166b2de32a0988d959209abc07d9ac42a974f7835b52db9f7cf3f6a4d211\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/7\\\/e006694.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/7\\\/e006694.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006694\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006694\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006694\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}