{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022MMYT6baBKpE+X4YoA+Acn+WSXkvDgdmVawJhubuiKLei5oOgwzo\\\\\\\\\\\\\\\/qW0QbdpYxMSIsYs920o8WF6WnZvjpFCLaYvNzJtb3og7E70458h2+nYc9j5PJ\\\\\\\\\\\\\\\/RaQMbzZjNp1toAbL\\\\\\\\\\\\\\\/CgUON3ADm20D11qGiQw4FCg04yGPPE5o2FhpTgWw0aQksbn0DMQwNkG6RmqMMaGLL96cProTIpks40ZN4nfO8WXk+aCjql6hI4HeVaCGFFtIBE4NEnDLd62THbfEflLhPRrWN27JbcEV59YCL2NAdXe23+aBaOBJab5xqN+qeRvWpCUkqoG7XICxF0PAmfxn7V6Rhlfx9a+XHGRax+qR9wYo1uTJyYYljC04MnXdkFUFOq+IB\\\\\\\\\\\\\\\/Z10cs7\\\\\\\\\\\\\\\/b5dePEkp5kXwjmaFQsR\\\\\\\\\\\\\\\/nFoL1z6\\\\\\\\\\\\\\\/pxIYmXhKJMX4kQXvd20OKnjf6b04peP4Y3FTo4xUcpKRhG0750rnvzHWrskl64QphHS5RVcx1hu6Y06jK7dLPHpcIcXX2sIqObE1+H30d1u6z81s\\\\\\\\\\\\\\\/SGj0N4AlKx\\\\\\\\\\\\\\\/Zy9DfhYpiHXTQLMoEAwp4\\\\\\\\\\\\\\\/cCXdNtzpAChtwb5PtnecRqdmVfvxB0VlBp14M+w7HOr4+mgmDn5ojR6RmjbOruXXCPQKmBkS9LqSgdv\\\\\\\\\\\\\\\/oqnTaL+mkiUMTtIvUvvVf5OlT0dljZ2MgZtvnoyOFL0SnXsN40vza6pb2ng2NcaMx2YuyI6EAfIu4qerjTnYheb\\\\\\\\\\\\\\\/6K2bWwGhoqaa5Lf9I+DYWazW90\\\\\\\\\\\\\\\/7Dn2fu\\\\\\\\\\\\\\\/59IGLmk5yMfw+waPbyq1+0GoRaW8rCq1dOdkRwB2tbcxrtiMH0SnPawFY0WaWvuJw8pA2rPK5NJ7ePzd5yQMukvfiDwQaV80G3j+sEIyDJQYc\\\\\\\\\\\\\\\/LiFDNGu+Rnwz\\\\\\\\\\\\\\\/DmMmv5eTWiajsFFGsXMzX3HzomOzUGKmENJlbJrmV4KcKaUNv4KqAIvyCIpzL+oPM95yRQ2oxDvaTD+e9hutyYomWzGUjMpCBSSqlmLOBZn8UyzZFhJRrh4oRv4O0Q64veZK3N7zdJqjQhsHwqwtWO8rPCdr1KrU3tmQqeY4JWUY5ntyNiXRTFiniW2EDWSkzy+Rn3pvoZWwZ7B+ZVCRNlSS231PbPd3vnbsPMQcQ8ZhClL8JU93a+UIj1VLwhu\\\\\\\\\\\\\\\/ujqOlE5AOQHOPg0r1WfAg+jMF7wLyqUV7YkYHMhIBTISITgddcu6jCGZQTeWYSxDAXPo+qiD8mK1C945gjfOK0hSU8LojSPQS3Y4yF1KmSLHvlOaCFJu4CPostIyjFm2WO76XhruByOzIpKPS0asEJkAwdMrR6IXeDT7MUcGp0oE0HMYJIDoYbahG\\\\\\\\\\\\\\\/1wR02BNQOQVpKG6cZbiVEXZ5uFguLZ1R5abw1ZYPHae8rxFQy4Bi4RTpg9hYz3EGi+VNVQ1r0OzpTkag7eXWY54T2yCYudUb2QMjSH9SArn1\\\\\\\\\\\\\\\/DPWJwq8KxUpA9vCtaAyeVJQs6lGL2ea\\\\\\\\\\\\\\\/mTXaftxL0DnePVbLqbWvh\\\\\\\\\\\\\\\/ScF4wIkyVuMlRkGpjRTBwjO8YcSamAOwPIpVnwLzG423+u9ZKISg6avLQSyTQOjiu8aJrzlVxRrkk0+Y7WsjCBlM5D\\\\\\\\\\\\\\\/+R0aobPP8bQXdhChc8LTacaKmSlBOHV+jaE9CMr1zPAfRADtG6NN\\\\\\\\\\\\\\\/KzkytUa2py1sEYKLD2VfW9F8jogNLWWhSxYbV\\\\\\\\\\\\\\\/asUy3T9p5sONh3iaNgS5l3Q7DwFaXEpjFgLyXH7ey4AiY7KHIMwaDyAMmgn52mYhG2YB8KgNBLzppz1b\\\\\\\\\\\\\\\/LjjMlNkS9yBM\\\\\\\\\\\\\\\/IkXtl70tac3PY0dyH0XnWeGmGqplpk398nlhn1UYT+Zw5+OahvPdYafuVusKZFWFdmAt9YIc1T4Mgkl10+vizkO\\\\\\\\\\\\\\\/xjUIvRKQIIfUkfCM2xMTwEV1ZJt3EvmTAXK44UwZaWZ3XrAONQoibgP+L0azxaWqPOY7S\\\\\\\\\\\\\\\/xqEI4mIekq\\\\\\\\\\\\\\\/a3GjktR0N7G9N0MX3WOL2vKFbO4rCg7uzTVcHS7rOTR8wOx+MJilRNrwgGth\\\\\\\\\\\\\\\/wm4pTZeFSjFj6iA0xXt6JdI3+gitUR6TStf8QlHRTjvbTqngfYi7Bu\\\\\\\\\\\\\\\/wC8v2F7gxjtoGs2LUsVbxY9sdQeta0e6xaAlGJLNNkiTACA41Sa74tRX+ZfY2qie6Jl+l+G05zwLKe3T28wJoORXW+tbbad7JUUE1Mm7EioYr0GnmGOYLiCKZDIKTQ8e7pTBzMMUiAnk0sP7niiNv+HQ8qerx9POv8N61Uepe48FsTQ87\\\\\\\\\\\\\\\/D4TKVfZGMY2QYkeqRtb\\\\\\\\\\\\\\\/DW3pnqIeM8uBxNSuefTyWV\\\\\\\\\\\\\\\/1AwuOkZQSqjIByz\\\\\\\\\\\\\\\/5eLDFNaB+yjHAOKxls3t4uTErHaNd7vYbuy2EhX+hShp9vNiJuP6\\\\\\\\\\\\\\\/Do06ivhW41Lf0rsUt6poNTdkCBu9ImV3s1Vuvt0Iam\\\\\\\\\\\\\\\/8C7\\\\\\\\\\\\\\\/1X3hz3HQkjqCF\\\\\\\\\\\\\\\/mwq7wh9Lgvhp2V+cTzhha5cjGH7L0CLPCjXZQDt3ifvyCcTVentN9mLZie5TPRnl\\\\\\\\\\\\\\\/VnIs7Y9fSpY7WBf8lI5wAlyz3oV4s24FyvU2nxIn8KTctlBxXa6akCN9\\\\\\\\\\\\\\\/FmjOU96yANntbDKrWHHqf\\\\\\\\\\\\\\\/2oAOPt447z7oOWPIV0Eq4IHwjAW4htkgXZFgQnno0Fe27aT8WwLwyuAMgdbQQtE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GkLg7GqdF+lATum+CVPcvw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229522ebc388d0bdbaef24ffc0dbe0bc8b4daedc17d5851ccb778a3905be3e37af\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/7\\\/e006714corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/7\\\/e006714corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/7\\\/e006714corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006714corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006714corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006714corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}