{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LzgMFcsy+PQDGbKAWckJx49J\\\\\\\\\\\\\\\/BGpgZufucPTwNDGgbrNeHY1G4Gx93B6JN6ndOOhJzgBGBFjwL1oPQ88nQjfwFud5fp3vLWOkQowQdMOyu2904AUWj74NjsOdw\\\\\\\\\\\\\\\/+olJf7Gk2l9\\\\\\\\\\\\\\\/ZR+hOrMgDvIoKx4t9CBZNSot66PxDFWitlbQkVzqEQ9UrQ5ls1CHyLfzh7Tgx8QyqxRgGykWZfgaYYC7PG6E\\\\\\\\\\\\\\\/3g1My8eJyERRmG4Cjx5ZamUYtP4xhS1f5IhFkid1bn2ph0RulR1qj1xzKvlHtv\\\\\\\\\\\\\\\/ISPGmQ\\\\\\\\\\\\\\\/pAcqcJ5nayfClnV0VzYgzKBI+oipRlZKfcQwBPZfLiPdlQbXNlFu39ohInhCgxUIlwCYPxo6RsidYbwIMRaLK5DkNh4FelWnaWx3rUnJEGjrwAUPLC\\\\\\\\\\\\\\\/oQW1hmE3vBaiqJxbs3cEKwkXSIJTleDg0wlZ1iUPLNUbHzyVyv25Kdy9hjnndij\\\\\\\\\\\\\\\/7N3wPmA\\\\\\\\\\\\\\\/f0vDOrvVjYRAQNgZ8Scw6TRTI+pLd0mw5TlE0auF9CuSv5iPp5tZvX42FmAClX4Q2J3NKAbDwmTrrNYrulGv1M7dQBp\\\\\\\\\\\\\\\/HCvjOEN\\\\\\\\\\\\\\\/vNSafRkYgLuyjaByqckuNaVXGeu9PLFSK\\\\\\\\\\\\\\\/BkVCKH+usHSl5BypHbQPbotbEkv8mpucUEh0no1dEVwGhxjNKMQ84p4ie5y+CDI0jcbHPbRJdUcB2\\\\\\\\\\\\\\\/OnAdU+MnkJoi3irflj+pn8g4Hy7kVU8EP0i8wiZWTEGozbRnMbAlBb1EV7bGNuuusF4JLSTaGjOIHm\\\\\\\\\\\\\\\/IbaJ1c7NfA9yQMaBxCXlep\\\\\\\\\\\\\\\/8iVUTde3vLnhCyY4IIDjUBUpwSdX2fE6qZJo38Z5H63SgnCXKMZToAHHNPb9A2Dc0l8+YypUpYqQWMknW1Km7wJhR8yF3j+ScX3lhNA\\\\\\\\\\\\\\\/MkffsQcMNYIucdnPzYQWJiMv9eiIUP8CrCLtMelG0dEkWt0ljvEHygs0wC5ZQXE4HoIpGKe2uYMx2NpIhF0kyQbEb0Cf1KD7pgmuqoH7f8Vo\\\\\\\\\\\\\\\/dNkJhGUUwHi4iTI3vmtAmtN8Xx1W3FEhh0n2IxrgXNsDocuGngnYx6V1Wdw2JqaFbHbUMpPiGa+HfoXHdKmCq\\\\\\\\\\\\\\\/7ZwSBaBA8ak59xHdrXqqd6Y+iSVw\\\\\\\\\\\\\\\/j4ziEfxHem7\\\\\\\\\\\\\\\/FYyC1u6enKcDBWu7iFDNZe+1I31MfURT7jVioJjNkKsPoeSyYUc4mvxOaXVL8cyZcYvf7YfNLXx476EnGFk57eiPS1HgFlYbiC+hcwY3fw3\\\\\\\\\\\\\\\/ZkYly7rpWjDjDtPxeX8I+yL+jYSFHLW+\\\\\\\\\\\\\\\/KWEC2JadNgdCk5yket+EKX1maGa1cQ1NZSyDHEJiaqmEzJii8vICGSFb5g+qfJgm4DjwGPL93bSXNb2+lgyUgjIkbotc2LnnOi\\\\\\\\\\\\\\\/Mk4zmu7bUGOd\\\\\\\\\\\\\\\/lnU\\\\\\\\\\\\\\\/C6aE+knkCZltywbaRv7sPkxAbNl43+g3\\\\\\\\\\\\\\\/9EEXzfOBHo5H1kr4ll6HDMGTkO2cNABtLbZwDnXR4KE6KEFeAuOBUUg\\\\\\\\\\\\\\\/2eACf2C494DSihPSrg5NR35ErjmAbQx8EeE1PB4KeRaijGfZKTKt1kGSDftSobkvXLZeBJADaRfw0LpyF5r7CIeY+ey4cEOAPNg3sBqskCNs2tLLmGnE5B14mYiHnZ8XWLMJuROQExRtELFdEC98iRe7x0sGMgyDk342b+mcOhYJzQMSwtmWEg81k1NiHs\\\\\\\\\\\\\\\/vH3Wd94hIcNOsP51nymHRjpukSA+6yLXhutYA03f9VVCLhhLIEOOuh5m7hTjofAh6MmWm10MyikVkGP\\\\\\\\\\\\\\\/VIIoOb0DzGV\\\\\\\\\\\\\\\/1iVt3vxUun6NDameARPHe5ItFCRKWdHMPJpB7ejuGy0pFABsdtzRCdVErnnG7bk0Ovrb1YM0F4WIIXs1KaImgmq\\\\\\\\\\\\\\\/LXFtxjJ3JRj+c76GBGNq\\\\\\\\\\\\\\\/r96pbQ9soDHLxOsROl8KAWmZEoQYRw49iL4SmbyyLSn6N7zq7QTY60BRpKum1Qh4okQ0ZC6Ww7JPXvzQ5enjaqRokhBP3TUE01OaYpNIVl5vm+ETH8imVUBFa5rKFauny8S6rXJA7xtcYUknwLpJgD7Ut\\\\\\\\\\\\\\\/qAmNcnibfcm3CQhQe7sEC5GRhpHgb4YqZvPyVZvxdzevHcfFOG1+00QCLPJKZLbmE\\\\\\\\\\\\\\\/ENi3YXSLbxRSiXS\\\\\\\\\\\\\\\/FKeZOeuvyc3JDCtEhGD2KbKjsnBEHGLm7UZhYHWUq0lsvAQ3kPf9u7z+vskWQ\\\\\\\\\\\\\\\/9HTUYEHwBkIJHE9yHYq6jS1FzRg2SOh9uW3SA5yXLfzEBBW8+aiOuINLyLBbUFC3\\\\\\\\\\\\\\\/DVb87jyzyhxlYN4X4avC47mBmqc6i4uLTTc2Vrwx6ASc9OjR2423Qa8QTj0L7YsLMZb2+0Gtvg+ntI1YjQXJUEw8OnzbEtUE3eQXvIvjRaEyN\\\\\\\\\\\\\\\/AMB4r1YrXAd3rUO8IAYZY2Tka3r6UK7iqiEcqL0RnV82LCQVwFFYiIhK+hyvgfR3bqVsliQ6rI0gKSS1ntaOvf7D+RXwze5PexycdAmqKqqxlaKZsPNVmsyf3WCPynwF6AMi7A49kYrI3lo54IB5vqyzB\\\\\\\\\\\\\\\/KI+cOPI9X5rBFt6gTOFFn5ZYXBbpVg78OWlrcS4Ge8gvUbQApAXKqeBkoZIlyHl\\\\\\\\\\\\\\\/7DvKEI5ETm98Q\\\\\\\\\\\\\\\/i1H3IbzUIdcOLP4xoXk+ZfyVPEbnU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hQt8RoVIjgs1BHbrOqZWfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022db51cb16e89878ca44f839204d96d55009a34a8144e8cf654b1bc68cb73fffc1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/7\\\/e006814corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/7\\\/e006814corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/7\\\/e006814corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006814corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006814corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006814corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}