{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hMN7P7Umbrv5x0DpAUsSOjgesv2Hq+HNnljMddlhwlsI4K7XJS0pLoKeevIFEBdP1LxbQEzkFF+2IZ3NXNnveip6u\\\\\\\\\\\\\\\/FpaVgL0WuBfKp5IZmM\\\\\\\\\\\\\\\/f6xLTNesoKgbTQ+11w1a7DsU1GB0eyzRAGdZd5g+BhZ29sYnqaWnBfdZU9J0yliFYCQ1ywLPw\\\\\\\\\\\\\\\/ElLTf5SmZ\\\\\\\\\\\\\\\/eNBjRcC2HoswgaifIrtu9wTjaTMYPP1NvKWiAXKcNNyhgBfzONf9Ub764Tx34GxTF04rW3UdSqmLwaoGS7OtCJS4CSY4eV\\\\\\\\\\\\\\\/iCVA0Iaw689Nr3yIZmj97NJfv90hwzaSMhR6V+0Sdqk2qkzsrdjbf4PbARNiCPKaSOrmj6Gl6\\\\\\\\\\\\\\\/NbuTUqC4+5QGceElDUyskOdBQo14Wrgps7SorJDwi+NDnlt4iz7ZpJ56UGlNHCV8N\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ugyd1BFsZPGZM1sXRolrg+IvlZOBrSSuPS4aSbPnbiZlvN7nExCjWJSPdpqLO52Ue5xH+KfNp\\\\\\\\\\\\\\\/L+GUxWT8VkQmng\\\\\\\\\\\\\\\/hoYSqwufb9LWa4dS8tNg8K6f+s3qdTEhOesS2WiG09JYGCvGDwxGCwCGtm4h2KqGHLMgVdYQEYj8\\\\\\\\\\\\\\\/Chnzpi42SPbW8TPPGh1jU72s8NGu6qUmSJ9RXWOWWW6e60\\\\\\\\\\\\\\\/wsQX9EtSxh68EkwaB7e00UfxgQOsSMvf3a3iAE+VRCnz1VXWjZstwFvw09uf9zI\\\\\\\\\\\\\\\/IrYiVipovhNWIbYutwrOh4HdVZGnJmlJy59D6WI8qRWBAXS2TKUhjvxzigT4Ammub+AR9dlkRoWm7XEatWTra79KT8OyDadjEtvPYbm\\\\\\\\\\\\\\\/s35Ai6EtvjW4m46t8DmnK4yXrDC21\\\\\\\\\\\\\\\/yizTKoXlhZCK4xqpBgBEkHP03BQpFUkwoX7ZrJpRSGYV5peKLPqkVIwkkkukmnIR3+NkSWazuCLH5lbFb+zCCasmUjN7babDWTNH6iq2wGdQssRGwFiiK2kzrERIc1ffo0PbZXoHIgQNAeJBTnivAwf\\\\\\\\\\\\\\\/4rKGADWXH1CVjKe3YuRa2h8FVnViH58tT1SlzpmW+yjL80+IPCZ77CqzxHRwr2aUiWUTlo\\\\\\\\\\\\\\\/fBC+1hukuBkmWtzQKZdg+lE6bQzrDwAzSVDhoeL7mSNNWyhRrs6OAfs+cT5BnwobRraZV4YZ+Kv20h\\\\\\\\\\\\\\\/T2\\\\\\\\\\\\\\\/Y5xDJyqnmRr7dULYo5y5EdvXMYUBgUPEYNCp1DOKXogppYCGko2Cyis+I8NRsNrXnYncPNzXf9YJlUkm7EUgvFMf54MsLKgEsHPyI\\\\\\\\\\\\\\\/+3X92R7lJTM7EG0ieK3Q5g6bKHIVXhCQxvHP9Yp14i9fUD0J8c+p8hz8JZpI5EYpDF6eKqeemMnwsy8Zl4tVA52z1wMfbM4ifjuN4EtSb13xVRvujQt4TwQZkXX1wFAeoIR1UcERnhVhkipcyl8j2kAwugtlzle3GMQTENx2JyaPNrhYIDiHglCXGe+0Lqdwpgl6YHJaLCqYTBAPoTrpcgRE0K3HcFw8KspI1ShITZtyjoYbZUgPtcI8pdJKGP6N2\\\\\\\\\\\\\\\/aMTXSDg4ZfPYATO4vUFJX5g\\\\\\\\\\\\\\\/e7hgbc5FjLEJCAMvTdEs+76c9PT47nAFjkyBeyzeRSj+r36R6grhWO0XTVL1EwuFDw8gGhxSFhCzO40pAcxr42ucI+S\\\\\\\\\\\\\\\/NtMh2Tqvu84uWxNoAW7C4\\\\\\\\\\\\\\\/Hg8Ci8K8NTiLy9NUAyeFHspEjiGlgZYKIrfEif4Y7fkqzqsN9ysSeDYYbRbPWOaqJB3QuH6eXMVmq\\\\\\\\\\\\\\\/OtFE7cUO3LCaj06ftIWNgLHXxh5in0ccQUWP4IopgwFDfgZ+4+hHGPkm0qpV6Och\\\\\\\\\\\\\\\/Xo8kV\\\\\\\\\\\\\\\/3sbFTmmDmOi5a2BfnuJkT3Nt\\\\\\\\\\\\\\\/xSAuHRxRJVkAL5e+gUrcSaqO903tf6iUl96cLUh8j\\\\\\\\\\\\\\\/0Zuv93GYNyFRl4W0O98iHCE9YDmfKf1ocE\\\\\\\\\\\\\\\/CfX0bBMJ5WOvtRB39tKDZ0HAgspYlbgevTxoIlS1Knx8frWlBgqmanV4tuUlkfytwrL8gkF5qknMKGvH2haRl4xsdLBjNEfnPuyq2H5Wp4WuNPC2SP3E4IhMmdlWelEeTwvCg2GcwoJwGThZuebCWCUL+MW8WFOBR+DQFJ0\\\\\\\\\\\\\\\/AlOMm9JrSaQXxG5kMopFT38VOc3W7BVsxDehoyuC8xzNDRzYPUDqBNfEfL9wSiSbs2eAN5khp9AIb1G5Bj3LS+vhOOSsqvzOpcdrGKuLCXEqf6zK6GdXfe0w51ausIXZ9PnLLMZFoguRfDYHYX5zyjaLLZX9DpJJ\\\\\\\\\\\\\\\/7ql4ZygHeSV962QzDJsm4z1OtNfBssm6\\\\\\\\\\\\\\\/Jufb4nIPDP6\\\\\\\\\\\\\\\/61UqwNOnlhctQSCvIdPgJF2SaBJgH+lyniEbFWLpjZqwN+HZSNvviwTLuZjZ4flyKq7Nl2AjYQUA3Y9yaeFxnQ8OFH3+1YbTKKF1CBsNJUpnL6131Qbkc2iK+Y0AODYWwOeNaX26Jm0uhIe382sp4TncWYp\\\\\\\\\\\\\\\/iFDqjDTcZWCMqR3CkcsKNXS+LGmjqFoINDeMhsmhKFi9DCbrHBdLyw\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/lxZJVZm4wcoapc+LzDRJDDZwOe1AaXY0BFe5QfYbi+dCJeK88XB6fJCSz4KRJ67i1MZ6DVd4kCaeAjEasw7meGv8qifqLY7L1zPLhxRSFg9+H\\\\\\\\\\\\\\\/pb8YL0Z1pNj4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OZkkS9oHywgBU\\\\\\\\\\\\\\\/QpOFuqEA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220221bb1f51ada3bcee68221744302be0d29b827440756c010783de02a8f8462e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006655.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006655.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006655\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006655\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006655\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}