{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dNlidxYzKIKMQMUyBSVXdeI3+6kxSttFYzXdf2uQNsZSuu2dRwJfwlbesURBOID0PVdKw1e\\\\\\\\\\\\\\\/6MFUYy70VxO9AvBs6q8ZuE4EJ2kXK7\\\\\\\\\\\\\\\/4h26Lsi6JQFBKYEbSDsUeYmwPxDHRnIf8sAlOqaeOBFHUtf7LZSIRcuXreCY67GV3PRVWylUHVZv5HceH5ti9YhwAS5cuMM8kpAhwcUaPNWHvgNq2g2Xv2AqmxbbKrycTJt4+JvNcvvcAmDxClDnb+wyXbaRMeXrV+9MN7YOHg3bIQg0DtblKD4pLS7WPl1XXympgE6KUHXTBFxwp3FGp3WoL810WxIUh3ljPxBzqdIOe8YGPO42cdBWSuZJcMDSkwPHe3ZL7q0F3KDO\\\\\\\\\\\\\\\/RMx7EEABnhIzgNglC3VdPyTApIhbSkFQ5tFY2bhVdO3xFQyIJQkLKPRQ1bYpWsLBHs7O\\\\\\\\\\\\\\\/IhpEw63gf4GSVugjztaHrnIxesx+88txxlg7Hpkj6tj20CluNb69vLD6f7f4mxJZSoxCnB48l7nBPkKm3bO4TiBeWIt9xl4jmgSwNP3QcC31boEpyh1V2d5ralir7d\\\\\\\\\\\\\\\/d6cqBc4jFP+pEau\\\\\\\\\\\\\\\/mtzok46NgUHv4cuKprBE\\\\\\\\\\\\\\\/V1RSUZSMbZv\\\\\\\\\\\\\\\/HD1P3uy7Te5FDQ55cgae+SIxRa8Y73xWaRk2gDLTH4FeGkhrxuxBwZmybR5B6VrT6zxYjWlV3i8AaVkq9r9Ocs9hEOlx2WPKkXfCAqHxa9i+Gig6sic83oMOCl7jlLDHHASguGc4XSPx9Azgm1c5m80Msd8rcUIwq96WUvUVNTukuhLAx7N35Ye4CZdR3m6k+mDXKQ\\\\\\\\\\\\\\\/xNdMRbzJjd4\\\\\\\\\\\\\\\/cpMkGypAFFH1WbZUH63K9F6aXVha7tC+Mm4NzVYEX46HEFqMjbogffOVNGXGPJXrOHZi0BhjaTifSGT8IwX3pD+nsCqRMCvYJ8qIUGelg6yxCaVv7M9YFC6CHx\\\\\\\\\\\\\\\/jVsFAwGM\\\\\\\\\\\\\\\/voJAjakxxaaXVHJUrKT6UAcs7rZPhedpKdCNEeucFQWDPg6GmgRNWp5V3rFFNi29OGU9TtRPqo3mP3S8qLhpM6A4SR3tsgeVuAeBr2ITw\\\\\\\\\\\\\\\/IXYLBiOEcc1VMx5clAuJ04nPG0Jk4F9TXg6hE22vAwr+\\\\\\\\\\\\\\\/CSk6l2i4l2DTy8C6o3xGeOkZhQH0l7lqRdEHERuYBYHUQgmMG4wOj6Dgq6XZtSChztFl9PN5V26sIOjdVGRLOhcdowXyaxOu1ENSJZ21r7fzGc9Ic+Cq9WigkfpJUiX6nD0LA+QhMl+G3toETShbMi3+O4O91EFcDNkSENFnhi4Zg4qrQmE4tDWYjjpW\\\\\\\\\\\\\\\/WxnXQ5ucUNoGUbpbBLRXve8GijyZl\\\\\\\\\\\\\\\/mhG+UZlI0H3WuoSnKIGw429Mzw1asfNabAGWI6NuCsHBHce3khEq7ToRgovUOHGofs+nYyevWzES0Jz5fmvP8FhP4gdRYaCVP13Bp6E49mLTc1EndmFTia8WD92iQ2jZGQSL\\\\\\\\\\\\\\\/RBtEnLPA\\\\\\\\\\\\\\\/9547UzjLbb7Jjruq0JTR5voa5X9BaIBHI81Ruovnh14P9FpkQaFNGQk8q1BfwGcZbELzIRMPwdkGomXWKCG9Ya6L6rKlBcuOpJ\\\\\\\\\\\\\\\/y3wvXT89J2jwI9QaTYq1qnVQDV3ehYiYzXmrue8N5yXeqCVhrDl5a9aIAWsdEzzk4zFpmWVSpYHke8iu2yJnrWumfTTA1kJQNytLSqGY60uDO+Xlxf9pxZ6u\\\\\\\\\\\\\\\/w6YUOiE4zOL\\\\\\\\\\\\\\\/lQAjEMfid1HZIARy+ccl2MpI6ZDRcFNiBpqBz7xnIfP\\\\\\\\\\\\\\\/+8X4m2G+ANLiGhdbxWqyc68QKjwa6b9BYG68h\\\\\\\\\\\\\\\/gGr0SpmeNPempyJ1SuqOMPmQFRHVcajQCqr31dTzbyRB5XOiyznlUuyEXZPE4jUhST08aasIdX0RE8+12vGs6gouqLqSKQT0qaHWBHA0ZrQDule\\\\\\\\\\\\\\\/RSoPXbkZR+MKqXl8yNtEix9QV9U5wKAMtIks8jSjNYRBI299yTyJ7Bom8DDvqjiUzpEjqThaBQQU82CSZdiD3J8dWneWZjEyCp\\\\\\\\\\\\\\\/ZR\\\\\\\\\\\\\\\/O7AOoXRaaFurZM35wLIV5i+4U+GOrbgbZ6IgXCxiM96jMbKhhKAldkO3\\\\\\\\\\\\\\\/GCGewL\\\\\\\\\\\\\\\/rEAt\\\\\\\\\\\\\\\/l9kbqT4IkVARqxZuOKx5pvUs6MpiujXF8qSGgN\\\\\\\\\\\\\\\/S0CmzIawdGslER68Jcp7\\\\\\\\\\\\\\\/pLwsrHB7MEg1Vv+SlFXEcYoFCS2wKQb\\\\\\\\\\\\\\\/EJx\\\\\\\\\\\\\\\/WD0sfzK2RcApJkL+JxW\\\\\\\\\\\\\\\/U86Z7yhyAPf3rz4PunDp3IsUD8btrXRnF9aVCGvXpCxZeehULC7veW6A\\\\\\\\\\\\\\\/eLdK36s3gU4j9xb9FPvSmgoCAweJyMdvWsZIB6ixKrbyUu5sm6mLBnSpHpnwAlV8RhGst3k7A8M7DU6RSZxPUySxXlBGRv86VF243\\\\\\\\\\\\\\\/VyV8ESfW9R575NF9WG0BvazdJnYzeaO5sxq451nviANYBUYnPg8sxGFoHx8eQwkvhWgiVARVL2tz0ywT9e7WH78A5xi35zgOfGDHPWMJ9eJIHASttrolBjkxymDVJHxV+4klhrYux6WvXw9knRwbKYCHDQdcX6Yrs\\\\\\\\\\\\\\\/upjyCZ1hYo3baOrq6wTcQDZ\\\\\\\\\\\\\\\/wdsGRzxaoka4OMyM7bDcf7XQv+XG5TZiWncMqO0s+7VaSsDj7Z77RL3ylCBDOq4daKKCE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00228+euKUSbo5Oy8XOOPxOiLg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c2c09a0c6a319b662b72735eab99323d4b98f3a792fa309b98b6a62e271c5fd4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P75.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P75.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_3\\\/P75\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S3-P75\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S3-P75\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S3-P75\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}