{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227kvioCS5R0As5CxHwDtSYDcWqMBvFsJtNdI2UWFo6eybXwME69CEv7gtaM\\\\\\\\\\\\\\\/HjJny4EyolA8200\\\\\\\\\\\\\\\/jQ8t\\\\\\\\\\\\\\\/xmZjxAuy\\\\\\\\\\\\\\\/7d2dfir3wiPmv8S6Eu9yV5QMDmHaw0FpRxcABkPeAZfBTIwQAlLoJtItc54LDlRgNvFpCCJwvdF897khuGk3P+jxBS10iL2v0kC\\\\\\\\\\\\\\\/VOfGl3Bit9+ti\\\\\\\\\\\\\\\/KKbSO4VLwLmI+GMxWjdSAME5qlDL7h04Vvt+hZSKXoboaYEHSnKyIoqF7rLDOm6fyEarga2eHEDD8a5fh4kOUjIg5uhO07EY2N3oaze\\\\\\\\\\\\\\\/faLyzTunbzuHvc5ZFZ9n5DEng\\\\\\\\\\\\\\\/Rb9r0wgi4pv4pT\\\\\\\\\\\\\\\/lFIqCUqXbhW\\\\\\\\\\\\\\\/ZG2r3iN\\\\\\\\\\\\\\\/3pjern55HKaOF8WR+ArWSRKliOnAUtnEfcTdyVORNR0RLdr3Ygp+qRD1YGWqXKCVUgcG6ESjPJ4qM3SBldn8XzMgFRxik+nJ7N2ARMMYDftSjlSEXvNZPdOV5Hbf+EoeZZXlTKZPGTMxbVCe8E4BCPQD83WpQSZy45z5IakKnYDy4s8M4LPjmLhCzRDVeE8+BSXsCL7aRp5h1dH2wmv27lqde9uUp+ePd\\\\\\\\\\\\\\\/pq2UxxtCi5loq0BQQtrBpYeO48qb4qacIczjVPZlsuVCqNlkNugKC9AXihF35W+xVjQ6arMCJgRO0tqP4JgJlALp93HJ5wMlwEbVqH4TLV2081eG9UG2+7I1n+L+ZJo65yC7rlM\\\\\\\\\\\\\\\/mTFRpdBvihGrVyd8y3kpz0eb49J9krV1LSOH8X9swl5QG4JBDIdx\\\\\\\\\\\\\\\/k2KWmBp9VprsEJOAbAJpSz+eMFimWZmkHLHKKAOwY7VjNDZMCmHCMQLw6SkdFu+Lq8NGjTtk+8+ToBkbsu4MLTrpf28sRq\\\\\\\\\\\\\\\/wi4+0b+Mqigs+DOXa9dlL8M9hgUM0KZflav3NY0hne68jRURY0Zce3F3QY59Uiba2OUTvTXOJs9m8ou4cwUasddBlXZEMtBiQbJgW+1RSaE3heQxxwLrlq1lpjAg5JI9Md6GWItTG5ESBRxwZCDGpCRDBPxX6slYPb6BxIEQxed0bsnYCnipxfM4D5eXUZYYZBgsec6Ljvvk8VDVu+GgY6minsy9xViVjZw8fWXwIta7kI0NFMVlTkLVOJGFMY8lkPgrar71rmuQpWEsJ4snR+MVWTxEa+tFlIfijEpE2tx0XCOJHM2ZYl3OBLrAvGARri3f2BkggXhln9w\\\\\\\\\\\\\\\/epziynEUtP0SNfk\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/AFbYhT\\\\\\\\\\\\\\\/JSpiGs7Hhn9L5m1SVRUEiiuP0j1OHHZti6kP57NyDPZeu83ipzh50Rg1yuau\\\\\\\\\\\\\\\/BkUbg65Lbf3goakpJUoZtVSo\\\\\\\\\\\\\\\/s19PWV6GlFT06KMZ1nk3I9cKT7pzJHybjvtHUjXForLKE4h6R97ppSjmPiyRbjVyAhLz0YuivCnjdPZ6CQ6fth\\\\\\\\\\\\\\\/ENO\\\\\\\\\\\\\\\/QKYCDDLpoZ8dheAfIn8ofz0pcIWgH8K9mS90MuKPOidtzrjI7bNt3GnMq0RKA+ndLbpS\\\\\\\\\\\\\\\/ivh4CkumhNtc\\\\\\\\\\\\\\\/YZWU6nBVUJORuToKhpq0ANUqRBcB0X3qkHNGjG7dmKOaJ2XOO3TJasPEOn6EmHdh3Mpe2X3w+0woSWMad0tLNDZ3Kr3WOjFz2WIhEV\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/Ilt59FUDcOLQPRZZ3E+qc4oyzmNXdoEkD7qMOcOxURSheRwRf91BIyZrKfs37Bmr3bxzvSTdODIqDXwYHZam004\\\\\\\\\\\\\\\/ZbRCv6QfLeIowhdnoYvSo8hxRGtCZmcAoeKN4++IYPi8A5ZSET5cys+ATA3zfI0BLvlW38XO+n\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/HI0Wdfpxh1NFFUlaRWzkuHCp5fgVbCywVRlIpP5KOIAUKUmYQ\\\\\\\\\\\\\\\/2EEHo+LPNY1ddICUWwqYS2Nalix0l8kWfE+sciElwCCK38WSfKYoJ1wy7MjoWTkXvHAuZZT7Y34hxziRTES0XvMYLonE6zt8QkvNqHhniOIJDB+4NPgMs4qzbxd5Ha5yFGCABcRt\\\\\\\\\\\\\\\/NcJYVB9X397Mw5qOcrrhXnSMcXd+eqEFs+lWUi0d7N77mwhAkj9WRLKCC8A5xdhaSAGgRKYi7O99cXAcdYzMkFW1fOcf3iTTFtDMmr48Fsap7jVCdGTcwgLfX9Ei7pQmnlGCrZHWDRGXIvbrPQRpIpXAGkLNs54CqTZpSrqRD+CDSMkbnGPXAY3LTquB9YsWaoLR3hAU0k7H2TM0yaeR95QGMXPpw2e\\\\\\\\\\\\\\\/YBazK7\\\\\\\\\\\\\\\/preXh904zMPg7isX1a4Cvjwg\\\\\\\\\\\\\\\/+SjIhPXwlx9O+IRyTUH+8re21V1Kgm3ggMWM5nBXEKUbBQ4v\\\\\\\\\\\\\\\/9abQIughQq8wyM\\\\\\\\\\\\\\\/ix7fe3iyUGsWZoS1bOcdZd6hMZ5o28VQj7VcU4y52OWhoRSBHOB8UW88IlLQvO2OWdo4IL0OlcqdEOIrD8Y9JeduUhGCwoZgEBNz8eCREyo133hSrwT8c0xG3lugQcQ83nwZ6mTMg4zM3rc7TENVDqwoltl\\\\\\\\\\\\\\\/HNptnBUtnmQ119h1EOlysDrzaZArzpgJbw1XcPH5QBznAriA7ysHjX28sz2BG0\\\\\\\\\\\\\\\/IXceSOBAiimtLxxPnVMPrVtxYMgEGTJsZTuKT7mbzO3pxggFW7RCu7gCkwWnnY0Tp1aRVKi6HdUE6LpKAomt4U5lj8a\\\\\\\\\\\\\\\/qgqRp3AUIDJ5VuF1js=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225iIQ5FnQ7YegxwFKDJF6dA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e44a4f0335339f076eb498c23bd7dcbe949d4072dc8cd8c7ad28047b8c0a4b33\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006166.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006166.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006166\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006166\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006166\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}