{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CNug6\\\\\\\\\\\\\\\/1qcwSUjcFY+rba3AIagUKs1DqkvhF80lTJIG3tG1BFrgrBWWE04DVfULHHuuNn47m6j6VpLwT3gbwtqpSe1iXGniNN8m4GsXcxNM4OHvakfMF\\\\\\\\\\\\\\\/wzc53NEp1bM2PJZQmXm5XQpZvZVmwiebbWMTAv9jmiDSEG5yk6CgymvfJJ5ZFxkUVWzYXR6gff5o8dSpg8H33Lg4P68JiTP5lEdzqS4Gs8c09a6WQlYzRMzg2pBbHx+6coWECBnkISMGw8bKA4o6Pb3OYaAwxSbVeObLvCHN4rG9jPftLo7k47MCCauzh4WI8F7pa5GSN4OmT3dPhmHnLXrbUkCQJhmzILOD2ZEQ22OeW8XM8l38RLL217B6kuUFR4\\\\\\\\\\\\\\\/0f2PFcUWFbQenp3ZGssWwKgRYrN9keXAHVIwsIStK7GaWGmP\\\\\\\\\\\\\\\/IkJXaFN5L68eZf5nr0M8erGlgAL9e8QO2GXMPTo09Uzlwt0njKAwl93h4nK3Shg0o2mZOQa71PQ2Im71BFy3DgO1nYyu9wXRotEH0PzQU8y4WAyGhqb6S4n6VBofNmmzDTZOcBFFJWKYMwhnh40zn2yhIkEaTKUXiah+hu0OwtqnPSTCyBKobvklQdv5ViUPIpOrEoPzMLYWni7UIUOGBD9YfchYHnpue5vfni\\\\\\\\\\\\\\\/pOv0Ec73kGvKikDualnF3UtcOSg8YNPJv21t3l+98zTvlkNF8KIj2ByQzLmMrIPuFXqY0y7p6DJFfgKCyEpEMQUF1Myg3N6eG9U\\\\\\\\\\\\\\\/Gq5dg2y4qVSadetXE7bsmEhpDlDObmRExlVnkNRytZpr4q95\\\\\\\\\\\\\\\/D14UaGdFmq1o9JqaeL4gPL0meLFFDEavGk\\\\\\\\\\\\\\\/IO0qfmxtTTWBJdZXFN8yopk0I\\\\\\\\\\\\\\\/we3rwsXQPD5ndLfyPz6\\\\\\\\\\\\\\\/9Ducj7SXEm3MjXl4NGySr0vOlorQeYscjotd3giaeNfQmEkdmz9uYRAg2V1t0cVbIJsF6oPB49quUX2xu6nODJDXLUq9BgU+5J2gzyS2ftm+Dkbx5PHpHKHPsLGrhPSMw8LHG4YlEVbG+OmHY6x0dhdtjDkwgdbNy4ErY+7LUTLgHGRKYc\\\\\\\\\\\\\\\/DHqjOcINsOZjnpQb+CuYi9FwhWz2CDjvhFQbygzPL3zoz3fbb7r2foRMYd2I5+bbRWI+iiWu0yOIr1ex8P9tcTTz0H8Ps6H4d8k+bcJj+KMw3v\\\\\\\\\\\\\\\/UxuIpECJiWLZsIXzSpXpVtSmwYNE7ZR1PfpykuJFlLpupuq\\\\\\\\\\\\\\\/YVXNxH6AQAEEhsJSxNPITBwdMRFXxzc0+lMdg\\\\\\\\\\\\\\\/TM9s5jZGkNMVIlbXzCZ2R+XKQlT+XLOzPdp0uCcsl3m9FtQz4bHQbJtryi5hqJ9hsTVh5DDKQARoLbSfTr5ZfQP3ALaKkkyTMlWQZ08VQSOq\\\\\\\\\\\\\\\/ffpP4PZzO5gqadlJDLtDLIRrYVSIlj07ozVGA4bSGTLTECRL8kPc1Bx3wjw6Ad0C4s0mWBMqKagulbUhvY3UnFCy6RzW\\\\\\\\\\\\\\\/vyroKTVOcJ64AJchkRh+czCZDN978RoAFex2LVOzl8kqZEuxdtS3oO0QN5QUmdd6zhH1Plnwgh1eH0nnY28EpvIJC1erEYoJTR0lj5d\\\\\\\\\\\\\\\/6O2ZcTDESNCRI7vv6pNC3Qoa7Sl5KmNcZJ3FSTYbHBlVhhEWPOQntW\\\\\\\\\\\\\\\/TkhH7KlsV+l92t6rQHHc348PNza03ZnMdxhUCWnIRnXDdYTOJVQ4YTQQ7SaT3oP4vRA2DvqQHshY20d\\\\\\\\\\\\\\\/IzfMMaoid0P7GLUA0fswU0m05r4XSE4xfjhlE37hpxX86wwcwQNJ04\\\\\\\\\\\\\\\/2OSd4JFwa02WPYJW7pG7vQi9zyNTmm0Oc3KqR8p7BeeNhyX35e0Zm9YZ1gRul1MJGGP4osETy0fkvevp6\\\\\\\\\\\\\\\/DLCTdtkZPKRknVfzZYsnMiHYddKH7rJVdhq91ihx55JnGcfe3L9Lb5s6KtYM9NvdzZs5lTaDZmkS5HwRXpa24EbeyQKa\\\\\\\\\\\\\\\/tjtxuk3mlouUZXJoqwfDrk8BWWj5vAQYxgHp1oQe6R9GbA2HqXgGOZKHtI6IcFJAJv1a3PyL1BALtg4vgMKPDkbZNUgEhOlDMPQ8wP0KimWWLgliDdx4UN8V45tU6\\\\\\\\\\\\\\\/vL+kb\\\\\\\\\\\\\\\/U97PS7KEStXYgk22t8U7Hkl1zQCd1Hf+zP7pPn55hwMbKabSmVAO6Xxy44STfBxw+krgoWE52bAczdJz2wHQNhXGam8fSK6UYMCEPkN0WepGX8mKVSDH+W+w01chPFMqdALQ8rquzCKwXe1P6X7dF9RqWTgPT9Luq1f9v9eI7o\\\\\\\\\\\\\\\/4rdW4yzeLqGhmJVsKU8He82p59U5PJu1cY9am49CFTYxSgowzHJZ8mluZgZhJQWmkCszvNrLX77j+GGaqLAS9O\\\\\\\\\\\\\\\/RxGBTPVCxI97qAm1TZPItRIRuyRfJ62+dzARatBt25XR\\\\\\\\\\\\\\\/mCQGN5leDTFVZkK3dcX4zwVwQDu08wHVztnMsWJOYX4hi8p0c01qgt+4RvGEvwWBMwO9sBx5vc4SlJIgWvu6RI9GOB6U7asXeUsWaLgXmvUSevgLcyiOeaseCJ48jEZGGGpXKsrfy9KAdpghM7l8Hx40MFXTMRIA5gCx3w5T1Pjaihz9KL4ymiHQMKwJa\\\\\\\\\\\\\\\/vEeZnfHf\\\\\\\\\\\\\\\/lup0eC4o+7DV6a1RTZ5446nlh7NiRZv+Cumaw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022nRQ6V7e8t7UghRRgzH1tfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002262d279dd8e6c76634d2ac30787228d1c9ed9c1c8f8c9e9063b60459cdab57c38\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006166.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006166.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006166\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006166\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006166\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}