{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022FDkHLp9ydyZYnrLQeE20UqwIzx97+d0DFrm7exNnkLMmXbc5QRi0dexw6QULhOJmcxBx0ZqnGoQCvJQ7PTvClU7uZrvnfcscyE8atUMO40cc1K9z9H02JSZ1KI8eMaeGwimHlnaD1JxshoN5hGaAWnQN\\\\\\\\\\\\\\\/CwTFUQ1JqwgoiDFi8dccFbQGhAu6URz31d1uB9HA6k4qD70Ju\\\\\\\\\\\\\\\/ot0jvMo7NgeGdPLG2+1DC+S1E6WJYGX2m73cw9hOmjgbZRwIvnUjHmwAs86SemWtMKq5attvCjk0SPhu6BrmmNFOGTgiAU4pfEBggPdr8f8pw8cj6yelS4gHVZK3g6Q3IJ6w\\\\\\\\\\\\\\\/NidjapRWgGViJDSK0\\\\\\\\\\\\\\\/JFMNubNZDxw07vYlrN705zThvTz0B6glva\\\\\\\\\\\\\\\/Mx\\\\\\\\\\\\\\\/x9sH60j8eBizPX5h0D2XAE3bRMwosa\\\\\\\\\\\\\\\/SJTBwxhfCa+cTJ3tqXR8BtsXEm\\\\\\\\\\\\\\\/gGMEHPcmdUu94x0\\\\\\\\\\\\\\\/NO4KV6NUJN9av9b8dSKfMLQX+eH\\\\\\\\\\\\\\\/AjILzObX6RXzP+4qNz7wlfUMN693tk9+qIKc\\\\\\\\\\\\\\\/Q8VFdJLBbMd4BHnDeap67rBnZur7GbGjPx1nSJmbP6yP3hlwkxcp\\\\\\\\\\\\\\\/Ub\\\\\\\\\\\\\\\/N0jRXwbOlAAb62qE69+OJ52UeOgCx1AILINeHW2ImDSaKmWRhsu4Tp20IFF4rYf4x\\\\\\\\\\\\\\\/PFrcmUdZLXfJ1JQiPuIaD3Iy26KAXbfb5ZpAtK87fhuGQNgDa8VKbFlaLJGO1xqhZvYEnc+xq\\\\\\\\\\\\\\\/yzBpp7e+i6XOJ54yJQDCbo0WR1NyzcVPc+27VjSEB\\\\\\\\\\\\\\\/PdN\\\\\\\\\\\\\\\/Al1eh4Se3\\\\\\\\\\\\\\\/1WkIYVR8suLv3GtOSH15K3UV5f5yl5QRvrs2d9n7N1VQD9RBgmmiwAl14QxHEPzZETzhovrmU2t7WrU7gp6+1rTf0fPzb546mub6SRX5pOSp1+EjmGC7Qv95I2iYQH5OWDXi\\\\\\\\\\\\\\\/dsJYamatbwMJl9RUIwiszti9Kh78mrz9KZAqIthZDku\\\\\\\\\\\\\\\/1rbJxhtff14q1lZVD1vdTb+xlXao+riE1aBi+64xoauasGCR688SFpcay+YwMs0grfEl\\\\\\\\\\\\\\\/DtGsViHQDhJPLVN8rZRYKRJ04DJmW\\\\\\\\\\\\\\\/Xa8+dWBXTPzUl9Tc1NJ3brPnn17l09PJTZGvkZ7QtqEkqzEwrCjEFEMk5olLrwUEwP9s6F1Unu5+Muq70XiTpaOjkZh30XTaEFdD4Tmo1UPoogFaKiRzyyWkmEfCn+WCVQlCgvsg\\\\\\\\\\\\\\\/Io+U6pTfs1wghuc6tLYk0+Hzh+1TxqDECuWzUpRl2Sy9UR66vBte3B1CGV5Oyw\\\\\\\\\\\\\\\/xlfFPGJ5Vv36dV+9VTTxMnRdROzooj2Y1yeWTCQ4WkT68W9MdpNAanJ9bhnWmeB3Q5Zx3DxsQtAjKbxkoyR1rXPLEfotbQzYfOGbe12vY7yoolUQy+knQFoxPBsCgx8\\\\\\\\\\\\\\\/WzJ59cTJ6gQCvSeVCft3dcCRHukB38101dfkyov0pztkKeSCP9Rm3hkAg\\\\\\\\\\\\\\\/sSfTFC2g8j\\\\\\\\\\\\\\\/nOnHTNjpC4cuS1Bz1sXct\\\\\\\\\\\\\\\/Ks7sHaORC0qKg41vj\\\\\\\\\\\\\\\/4H91g8qWeffZjTIqxPuW5sokql4y5fEoI18\\\\\\\\\\\\\\\/48ZjUpwZHZMABu34KvsqUwO9G\\\\\\\\\\\\\\\/RPHbH0O6j8CrK5OAleapikCqLny\\\\\\\\\\\\\\\/W1ev8WTBaOH4ZjdK5Ca4LZ+bb6VtQ3PfwpJuPDQEzhhawMLtXOnYN5xNQLvtZdNvSYWd1zvY1IsV9IbTwlqYvqG0wesamPvrLQwqECIaV+kD9PLcRdN7b3jC3Gv7WUvtQZYfEFv1uxXBEP\\\\\\\\\\\\\\\/9Y0Vrt8sbQ4y79nBZhSSZ2WN58jYLBlbuK3IrHj+akHj4xgkVI2XXn\\\\\\\\\\\\\\\/AKUAA7f9ANvAXvbAyw5Kiv+n+gPoa8gK0aZ74TXWCF85I4jCD\\\\\\\\\\\\\\\/90N8GZuMwG3cs9N0d4h4pa1hyY9s6adRHRohBe\\\\\\\\\\\\\\\/FXNYDqDQXLBrrUsP6M2\\\\\\\\\\\\\\\/EimWYyXD2LFbilgCUGqeGePUKWHiGSrvUhMSv1nD6DNGfqDGvoQHNWO7YjoopjJNw6jTncjhNf1a1xYqvcuY92CJnEEifugoUQ9kV+KGScTCRbNKTWbEJJ+R9lJzZQjuQ18qitcNeftGcPVTBLhA+6ALNfGQ5kK6LQl7SIRmEYaRW\\\\\\\\\\\\\\\/LjvT8CiNyOSiCFTmjJhf0Scx2pxdD\\\\\\\\\\\\\\\/9PDrJ1OH8RxqrOfRigiBMTIRE42bYESfffraAkqPdfE3ek84IgDmWMY+j5QzDbfmDCs3QVmu7NMEq5BQ7MfBZduouSa9TyMyq6+EohJcBHCCFRCfkYXYXR+eeKYjgZqwu3kFAq59z2DOMx9dThnJCIaUKYM\\\\\\\\\\\\\\\/KLTMdvBExBEJbHGLtj3JK99sopsov3kwZtxTuRh131NXc1pxywLcN1w7MsrdXz9xXF4WN\\\\\\\\\\\\\\\/Eg4BmYn77lZmoj1mMINBAaASkFMJ0IkIEtay0i1Jg9nysXFVox51tBvDSftIdQM1xIIfO8\\\\\\\\\\\\\\\/ZoMOFf+IZ7YfIl5wno+1t7Z\\\\\\\\\\\\\\\/EYw8Y5OLhrVIJYyz+tXv4UgQdAx5AjYcCEVOHBITNnsfK7IxKopLvJVcPV2aGVNxutquVXr+1FnuJMvvy3jD\\\\\\\\\\\\\\\/iT7t76EpI4OaaojDXexSF2V+CPl6oXS+kTuhQfQlo6MsXCfmUfLK6yIvL1A9OOn7zx12CWs8R+Eu\\\\\\\\\\\\\\\/wD7\\\\\\\\\\\\\\\/fcLNMIeBcE6fmar3F+I=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022P7ulKG9W6pL12rljJ\\\\\\\\\\\\\\\/+IHA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002278b9e6e7a101177b34de214d51f062aaae317a95083243ca9591279c6b18aaa0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006582.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006582.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006582\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006582\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006582\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}