{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022APJUv7sxO\\\\\\\\\\\\\\\/+AH8upQJS0TjwGz7Tlnv5IpmCUXYvLnExr16nRmGR9QQQK1BDLMmW2NCkJhYbkPaAG633x3vIC1wQKS7LJ\\\\\\\\\\\\\\\/8+jMx\\\\\\\\\\\\\\\/dNjfgiQQ6yYWPhk0x9JG26lM\\\\\\\\\\\\\\\/rD5wOuhIskKdtQVg0cMvQ8EHeLZogtISQ6CikzA1MTIEEVYBNJ5Y9gz8xLdFI1V07tPIf41OBT\\\\\\\\\\\\\\\/HruBiq3pWJ7Oaj33cpBQexL7Ja7gZ2+vVpPMGz5es7rpvo3vEPqBqf1fVAsuO4O0981KHzXD2QJJPfn65rWLDbDCO2rhCKTFFKC9133jRAH91vlPUvsu41I3H8VqrqwX9eNggjPx1KKh71IlomCcjItsVCMuJnMZ0VDbl5K3fP9z4Oo46Oc4GluQiAxDo\\\\\\\\\\\\\\\/RIk3DqGqSPRr6E2vfbUS8z\\\\\\\\\\\\\\\/DMecRzWEwUPoam0OjcBR+NbQKqbk7kpms4WfbHx0ukHwLD30OWsJQIUwpZbtrsRpf3fgft64sQngPapvzRPqv\\\\\\\\\\\\\\\/IITsq+BBuzHebk7At5Yc3mcYvicdVUwY7DMz1AIQ8JrDDYKI4tG2MG8FAHcun7u86xOf28HsMZAwX0k8agtB6mPGfOJYXdjSd\\\\\\\\\\\\\\\/6WpR3XpBiwK2UlGrX+Xp12btLrS8CoRYhillDEVlj51yziSxB90cLgYKx6fFy4IjvQr2g+rS73DFd2q8WUqIGE5nTY1b0XXWHHlW17CJ076Mc+Xm8yC4PLXl9VzGySYm+JZfPje4L50nH5NDvYlKJ+VqONlZHbMlWoNvy9Z8qBRKyBe6vbRnWe0zGvWxHjoaa29yH4cruwG\\\\\\\\\\\\\\\/IcRfKUi3dd+zI3ABRRaTR\\\\\\\\\\\\\\\/kuacNVUZ00J3QoUsbO7wSr1fNvahTyzOLc\\\\\\\\\\\\\\\/lP1OaOaQwmAKnnMSXG69Wj7c\\\\\\\\\\\\\\\/mZnH51j7xZLXbUS35knlOrucjef\\\\\\\\\\\\\\\/tdhxbJ\\\\\\\\\\\\\\\/MePNpgtn2rQz9LguMYzItHrO9jJCBmDzy2auIqa1vT+dRFp5yB1+86c0Qb8EPAwzGF4bVHBFdzLq5Hbq0XNFIKHdA3KkFzX+wTV8BPv4X210pvs7flMm4nQnIDm+ENd72Vhwc3HMSwf2C0dET0VLg5D1UphKWJHOcrxPLJDbRJf273cwfT8z2Onl39Qwyj8YeohG8X95RPmmwQLGNvcIRFuGDZJemrhJqZLyiGb4cZXWO\\\\\\\\\\\\\\\/z+2MUBGzzDCyArQo65otO8nSCnwSIQlbOfMhBrJs50UGXm9EeqAXFp2SuvPbRkmvFBFXHoYcDq6OuvUD+NCu6UB3Sxfpob2L06AkJ5wFXZusPngoRuo3bvKjZea1+nrYD4zgZi8u9CarMBhcmR6Yim1bMQMCk74K7I6lEmeHzcdwja7s+0tlRbGxUo0RkpUBSLt5nvEsjn8ru\\\\\\\\\\\\\\\/n6kSlGWSdQUkpNgFG6XHu4xFhkK76\\\\\\\\\\\\\\\/gV4exuAjBl+CPigk9fUCRyP1q6uE5b7PL1kQsV2cWSiotSIqpwvQMJgPRJfQkDQrwuYydYfNU9KbmrtNuMnwtS70trYcXK+aZRsrs7IwBdJx3uL8Rw7X5jd0Q+MF5KNCo++IdGF3t4tKn6rXnl\\\\\\\\\\\\\\\/T1OzxBmXcngCQkHOsy+C3qpZi+3A4dC8aennY18Dhtoy1QYIJvIPR2KnnXIkw\\\\\\\\\\\\\\\/GKJElyCJxLItOpRCDP2rAw1X48cFAcSwqb+P4ApucG1wp3V5d6\\\\\\\\\\\\\\\/UYqou5VYk0HsmZ8yYtjQQT8gO\\\\\\\\\\\\\\\/P9tMlQgq4hC294tL+XwC5WtUSM9MzU99CdxxpglKBs1bg7tLnKakye5XraMQHyB8WgTF+MmgiE2aZaketp7G6SVubf+lZpuBE9kAP3oEKp8lWgvps8iPsAQBacupLShpsJ4cyqdjJK0ERwb7sxc6zY9R+kMsf8MMPjO9Aa7OysCK5yIQ99PWyW4agSkgvdMdXL5nVQOO6RvojjlVCKcXwrdeI1bdQ3LDVwaDAYIDz3wflyTZhxzUJwqN9uUVRO7t\\\\\\\\\\\\\\\/fHNsH9MBhUlr48T2i6w5KE2OsLCWVrzpKws+jCxMnUE36sMMpqTmmyV7iyjckvmm4\\\\\\\\\\\\\\\/W4fPJcQcE9YjI0js0ox6bGvjG21Jim6MfxUrcyVwIkMdoi0NngXv09oDIMUwqO4CkpKoAJelURGeSJbiwvlX9KVZ\\\\\\\\\\\\\\\/mLmNOUJcoO2HHqF+pJzZLDkPhJP5v1BTamFHQQNBRWPcqm\\\\\\\\\\\\\\\/qpjVEicc0afdC\\\\\\\\\\\\\\\/gyRDb\\\\\\\\\\\\\\\/V5wQWpwbBX6WrmMNdH0T8RMqgHFViI8wUbPjcCtVnvZZIfwAJqe4Gkpo6gku2QtiUk7+Azy5n2a1QVYg4iB9nt3KdETEi0UqyP5DyFSILrAnjE3bnK4xMY88E1LW1sdUxaJC0INMRAM6jF3nlXO3MuyGpDn0cCP7AlJbHLvFW7cFC5\\\\\\\\\\\\\\\/oxJnBlGfyIFEMiosDt8pAD2E3I3EiF0ua1KqWSaccctwlmFlA7xwCBV61n5aHS2qlWBxWKEn9QaY5eA0SAlmINFP2GM\\\\\\\\\\\\\\\/WYg19VD\\\\\\\\\\\\\\\/ldYX7p8dbChi162XJJ61Brm9V1SEAlyi0L9t63hHIfLH1IrPdER7A1FYYepiGiv+5NPy\\\\\\\\\\\\\\\/72D9xGnfKzB8cDb7h4n+LAEXvvm1xcdfRwvg\\\\\\\\\\\\\\\/vHvtRKUtHFtp2E6iXIkgRlOIfWX0su5QBWcrRoH+U7ZicasmFet5b6lP0cZqs5yh5A=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Pl3U+sx+hq6R8SBlv\\\\\\\\\\\\\\\/yeIA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022af0eaab7e9561587b5a61ca050599461f7580e4d1b575c060ca8aca6eb3b7d99\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P23.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P23.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_3\\\/P23\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S3-P23\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S3-P23\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S3-P23\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}