{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/vJIeOBdFkV71XzBGG5Mz6jMdBa+xld9lq7omygS\\\\\\\\\\\\\\\/jnUeJIPwhcUE68pCy8jzrcZeLRxW2VQRLgzLJ5j3HKOZQ6+wTSe3rNZwPvsPEblTS2S5xNamgYW\\\\\\\\\\\\\\\/qEREN062tkFODeeSqKeirh209z6yylUp1nCkCbW9MOfEM6atgYWVFYWIVBS7xjQQ7F8\\\\\\\\\\\\\\\/3d8ToFkhRerIurUz8348X8Ttd60qmpfFF5x9Q66fw0Y\\\\\\\\\\\\\\\/+jeYB2oUZESJGPjMsNyLP1lmW1vWZPzQ29WRe3ygkw1aOQTEhvM+FB5DL4R5nOSm0m8uSCDQ0pwNCwpY5Ed1FYE3Eqtt7HYYl01l4SaWvvAWzHeQGAuQrMH2Q4C2XHF1UEbIB6EsETjmQB4Pw0xcV9QHLjBhQefpBi84at1Lu4XvRlYE617n+0yZf7yVi7f745dILMdAzyCPKxnRT60pC4AtZtNRwhz0tBDNqfAh4rtwZ1vmXiLOomPboZYgx36SR6Jdged+QRTG06477V6E+m0V0nlde2SZdIWmTw+tPc67Mzo12kHZreD0B8t9BaKq91Ep4\\\\\\\\\\\\\\\/RtRSFc2lWgvz8Wq7qjivuxq3HYWKg5q3bLgsFN8VrkDF28T30bzNY6\\\\\\\\\\\\\\\/oXRIs2DUkWX9VnaVM2PXJhXOXx1133KFFhbmD1VCDE1eMdpZv8KpsD9DfgYl7qlOxXhUdD3gGb4Cl6Kylt8jp1e5G\\\\\\\\\\\\\\\/Vgg9cyYYn4lBjiKrfhjeH5XzzkEg\\\\\\\\\\\\\\\/OVbYUwnVufBQNqLC+Fc7IW4T2cwBHQsb2FCmlK2d1zfoN4O4Kd1C3EmbIHr+eodlxM9X33+KtgqIZK5AnYKJYkUWeVpsyjZK6GbHI\\\\\\\\\\\\\\\/JfgEh29yLUfLla56G61+0OLxYuglvVQuA2+iTcfjJUPJUz+PWnA6POvZmSEfMj7Fs8orTgB24iAWYbDrt+s7dIv+PPHGEIhOYCBdMvtVoXwZB8b\\\\\\\\\\\\\\\/9btH6kRWa3ORPR\\\\\\\\\\\\\\\/qNfrj8IhEHinacqDMpkwBG2xfpIwlHuGf89TGpaheqOT2gTqdFnlZWcfP1gCG6j9h7RBWEIXW3Vwq\\\\\\\\\\\\\\\/M5w97OtzMEJDXMXPbjeIrIUc5Lsd5SPq2x275\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/EOtmGJ3dOrlElWO0+PTmLhg3+4BK7LtSiHcV5zuE5Tlnb2qb0rrianIHkaoTmm+LS1TbHZx7nN6i4pzaxrgQnOdFGEN+nBlZ2W42668R4OKyFwFL90k3Fwq+zR1XkJQmx81vLYnfiv1t4U3khMMNelpkDlLgj98P+p5W9NnAR0XhaiakTji4NnttVJn7Jy\\\\\\\\\\\\\\\/ck1BDL8uYWy1sb5s0jdq\\\\\\\\\\\\\\\/x49y+Y23grdCeRB\\\\\\\\\\\\\\\/18G8aUVPpkW5mRX57APKuDF2KsKdzw0nkeHigErGNGrrt0hFirOZa1hyHqLOQa9miPvb97bVr0VvQEzjmnpbAqNaw4mICqQHmHGXi0ZQfIvatCfoqfFZ\\\\\\\\\\\\\\\/lxiph6IHkw8o3bXRb3oLXbvdSksKnKNuP8+zjL9nHUy7ovqZqgQyGBpI019LB2hItIHYbLNhkleLBwEVFAe2pU5ggEeimxlwG3CuvO0zcG\\\\\\\\\\\\\\\/gIsdDVqEyr6XQryX5qiUUPJLzaV4USXW9UqMbFJzD6hOOnPMVXM1V0qKWSl5HsCqOf9kYn0VH+Wu5zHGO0R22ygTWhaQ03KfPRWHFHq7X8qvlA8CLWJpIEkwQ8n74bYsXtod80n2F5skmoedvolK6v8jYYSpqDd815v5LJUn5lUblfB\\\\\\\\\\\\\\\/LmzyF6AwBdr1EClRgIrtDjk5wOsPDV7t5XouZBAJKay+hsg2b6zylD7wMBdJusyFPu5hMZCnhQgfNkqW7+\\\\\\\\\\\\\\\/uIkT5RBF+xmHrirLbCoiTkoSu9CLg2iVG7nrYEnb2ka3gZnmKAXD+gsqwMvYz4tPKS5BdJnESp2dBg6WFphAmY6Rv8lYPCQlKczLgKq0ug6lsffq8Nfo4H6q9gPaXcR6LHmFw7\\\\\\\\\\\\\\\/7RVNmM1SB\\\\\\\\\\\\\\\/wqTpVxrE6K8zg\\\\\\\\\\\\\\\/ukUB43Q\\\\\\\\\\\\\\\/XJQy0bLYTnRja92ijAFJ9LVok5NoHYgVqtVDIPZ5rndc\\\\\\\\\\\\\\\/nVVTLIudkQ1F+PG2ufDR8Wwb0rzI0a\\\\\\\\\\\\\\\/fkopKt6xd+cpsr4aoJnAb5YXFPU+fFwzqzlVWbZGxggQEW3Rvbxzqapn+de95LiTUGV447btAlAyym\\\\\\\\\\\\\\\/7KXJb8pEqVBncHZl69Dm985obJ2GuVI7GgosC3eD\\\\\\\\\\\\\\\/yIDi7V+Y8myLrfDk7DkZ7q314UhTsaD0VE1qMBFFZfxW5YYhuG\\\\\\\\\\\\\\\/lwrwsuWX8gb+wKAH01QCdKmw\\\\\\\\\\\\\\\/D3sAebofELEEFpXLnAmQHCXMr8L3HGlwDTitADBQw4Ch+tkH\\\\\\\\\\\\\\\/RsP++RnWNy+9ItmqMM8yR5xAXG6KS5ByXnVJDj1vkrb7vEBEdXipL\\\\\\\\\\\\\\\/dSuQNf6yeUJdN4eZGpSP1oaJGHCHFV8BUsY+UZKA0yOdIBOMBMCyKEKjgpRu16+jdeyk9Ppo8bmwF8Zk+r8ERPk6dSNAO\\\\\\\\\\\\\\\/ckDY1B4LKOSYLMqsVVeOTTyJKTvQSfoh+LsHX2GSxNv2FjyK2NOCG1RmFq7\\\\\\\\\\\\\\\/aklk+3QnoRF9Z4fXf9l+cH5zvN\\\\\\\\\\\\\\\/C3QweHlevsy44guAgINUjwMzNPYPmjdDlJQiLkw8hcIK2hSCVZ6XuVlQIbpAShAl0u03hU5HfaL\\\\\\\\\\\\\\\/tqH+DqT2gcr69BE9x8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022RubxWxUGEXJBrzwQ\\\\\\\\\\\\\\\/0kvAg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022aa24714dfde12fc0fed983a7043c4cade8ff293b3763285e80b0171a0f4f0e28\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e007397.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e007397.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/6\\\/e007397\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007397\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007397\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007397\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}