{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bcyUDEDsuc18kUvfo0rXFJ8Qe8NeZ3oozk8O1J8ym47\\\\\\\\\\\\\\\/mo9cOl2zCtVQJL7P226AN83go8qEayZwR4GWOZ6pTxUhbZT7U59YCtlfjbgOTj6H1ijvTNPO61uze5k6AoK3KGL948geiaADQ2Ye5UsagI\\\\\\\\\\\\\\\/WBKqmv4X3NjDjHjaJxqXhP9kZ9i\\\\\\\\\\\\\\\/3Q6i9mppa7f+kQyMOD1QGwoZfl5gCQkHGXbCH0eySOS92P0NhgHzA5x3wobvDi+GP7cc0sW\\\\\\\\\\\\\\\/g2W+VrhHBybFp1XHl4i262rP3Cbqblp9yM7gAcGpTM+w9a8SCgocZ3BcG57wA8bo7LL37\\\\\\\\\\\\\\\/MpFlPhE2v08b96EskpAkQGscftvUXZKIn2r9LBmez8dfBFqf\\\\\\\\\\\\\\\/QxKiMODDqPgpnIIdaOdh1FoTNbSXUFLGP4gwzOESs7u+vvFVXZSiv\\\\\\\\\\\\\\\/H+JnwP0p6NuK4TDQLOyBCTtAWVqkZJtZ8ydWA6PbnjJhJxuKhxX6nrHoPtxvxbHnvMjSTGnWzulmPbD5c7MfQWxZdGAHmPDlCHKyCTLeSby9qFrVRHPprAFdQ90gnQsIgbgk2h4vxe+UZOv+4G\\\\\\\\\\\\\\\/WV5zcRxA0wYIMmevkLjkY9RbhpBpmD9pjaUcEomZHPagMGEwTusurNVeUl3Cl7Php\\\\\\\\\\\\\\\/e7AFhKhXt\\\\\\\\\\\\\\\/7dFXede+iTFxMhOvDO2bj8Zsyw5II4ObEE5Ah6C3NTeqE3A9N7iXbTX4SVES225w5RFFJ3yngCifVMVadsR8rkwrLUB3qn5FRdvabuzZZOms4m8Y2bUWYyfUy\\\\\\\\\\\\\\\/KmZldRWD42MvESyvLb\\\\\\\\\\\\\\\/vjmMu7wPBHbtZq2aszXpUxTLypPWu3LoZ3qV8ewL27bmPSgir0WCqHB3HynhqbIFCG4kBRDDi8amAvHHQHAy4JNazml7qGesU+egLpaSVoVrJJmNHwzIxOycLE5I\\\\\\\\\\\\\\\/Q0E8eyaydGP3J7KetRfIHwKqrgFgehO7qoeh7jC176N\\\\\\\\\\\\\\\/AqRsep+KApdwkN5s8i0MEOaYkcJ7V7Jx88urcnqSe4TbNuQJAT+SJ3uMkPHwOuU3Iwi+nACp\\\\\\\\\\\\\\\/2iHlKWldycT0z7qCskjs0VgQP7MdC1JR1RuuVA9fOn\\\\\\\\\\\\\\\/0qM7TWh2+uhxfJeG4Bffv1KN59zLDDaOmaYgZzMWtDVo79YBG4exoYmXVjHXXfACFkJQ\\\\\\\\\\\\\\\/gDmstEhZmmC79cvpVKTGV4ii60I0gawW6M08bBSWW56K6U4cb54g3oezVOGxO3sSlC86S0THKV1K5LOkTyGT96jn2fBgPr\\\\\\\\\\\\\\\/gn2tZyTJUTIpPOf1GRk5zNZ9kohO\\\\\\\\\\\\\\\/xQADnr0sQqrSnZonz\\\\\\\\\\\\\\\/AN2HuDZVpa7yzW38GbnEEnK229bfOvmCTsk34+7+RhfrVJz5f6SD5ffMsq1ce4r6+DhGLLRtKHVC2SsjN12J5upeQ\\\\\\\\\\\\\\\/JDbzwh0OfAqOud7WF01Ss8rGyA4nKtLKaYdQicdpJiREecLRBCa7ZqbPYqm2+OHAuoPlsFbrXDky1jfYkFmycFnc1Br\\\\\\\\\\\\\\\/QzvS43eaRqIpB4H8QeliWtUwJs16eD2Xgxx2YW6IZCtkaUGUZISNEIvh1qma5Z5W+GzQmpmeb68wECL0GxubIAuDUNJcWL4xSWAikg8ZtAaiB00vofsyO+1QBPKs3wfjjt1y2MplXulpclU4api7U0Hr+MMrlkdXJiqAB2N+LcdH9m35SgJaCRPZXPCpZYJr6nYBvT+bjzmJs6oqiOSWL0RI\\\\\\\\\\\\\\\/XFhAyNcf+Qtv0qBdl56InjEwAXF+fnP9O24Qzh3JM3bJZsCKQTRfjCexAxBDPKncH+mMFnAo8SPo03gU3Lcbdw2RKjbbXsbg+TIGnxZJ4ErKd214eKeODJ5U6FEoTK1bqxx3UcLCWnPQupQSZi5Q9Req\\\\\\\\\\\\\\\/KXBZ\\\\\\\\\\\\\\\/+Jlj9ublxzhth44ErOtp2\\\\\\\\\\\\\\\/kfyYbOBQwV6n\\\\\\\\\\\\\\\/CDBvhKz2Uvl\\\\\\\\\\\\\\\/CszdXFi7rg2eQvWL6Ai+IGVZ2iowy5D\\\\\\\\\\\\\\\/8VJ6OtMGWXivCNtQ8LCq6b5QtpfBZ2iN1T\\\\\\\\\\\\\\\/Qy7Mu263gX\\\\\\\\\\\\\\\/7S80Pzrlb1qdprSN7K4DzjctqlQ6c8HB2EP4NLo7fQK0KZGktSvDLR+VKdYhZSF8jAZEibBOGnPIrsGEQva81WrBIt4F7NELBi3ioAjLlymNGzTP5nB5GPIYZMsRy9140McR8wOVTJdroZEkPOA\\\\\\\\\\\\\\\/Vexo9NqbPkkRarqNRQCIvRH9\\\\\\\\\\\\\\\/qXGFhZzRL3HU37BbspCgNZeK83Zq+ukmpoM8AWyP34Y54siEOhMJA5ff7+MaK36RJD7fI0B6d\\\\\\\\\\\\\\\/P09zieAkV37985rZ8QrHrn2LU5jw1JqCk4L5lDJ+B6waboGywVJ31OPrUH+EiijvfW8xnaL70PTw0vqUH4639gNogTYCR\\\\\\\\\\\\\\\/F2OXL8qa7tr\\\\\\\\\\\\\\\/YZe\\\\\\\\\\\\\\\/HyrFkJdIc3lF8Y0LgW2TjTUrMOm3mgbNyims9zQGJFhYUACwqYh64Tk7d46hex+RYaU17DhFpk+xvEjWMvwPvTnap8mCt84DrIzqFFKA02lR8bocBzYaY8QfPx6dYU3vqXQ7bAlYS3SCzTnPy9xeJdBameGPZXYGfL\\\\\\\\\\\\\\\/oPvk0o6k68i1gKSz\\\\\\\\\\\\\\\/6SS3W6fYRjQwKvBY2rBbmPTgTGqY\\\\\\\\\\\\\\\/1Rc45u4AAcmoyzhMw8DzXZt4RDjOhdcbzJa9kbbQ8tobfCsPBqMHq9\\\\\\\\\\\\\\\/AX1U+XTpVaDnxRek=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224W62MX6IHQqa3mVcG6A13w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002223f240049b21bd3c296cef3fd79dd8ac1ddade95fc5c557df6003b71597bf9ef\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006720.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006720.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006720\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006720\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006720\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}