{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022c7w2g3tNjVuWC7fP\\\\\\\\\\\\\\\/m9a6v0UKBCwV9EpRFI4MiuAL\\\\\\\\\\\\\\\/sbYH1PhGHCKVsJcocfZ10JElIyqBFOQt5kpx71R0EPZ+eHiyUarP+gKyLZklYgm2F06a+chMMnbIRHpYlhsfq3pbpfb5O2mX8yEsXs9Khr1ZIpffOY2DEVwmcTTj2fTtx4EWBtuJyx4yp7Rg6s8sj1BU8i7Tf\\\\\\\\\\\\\\\/OQ8f8UhCuEwWJzjoIGud8UuYdRYr08EMy1hflXGiDKQENCv6XFYAIDvtrxT6EyK1MWd1jAqLWBS8AKGrNx2bD6EQ0FdApCUXBpdk\\\\\\\\\\\\\\\/+og2MzRfx8eD8KY8tdxn\\\\\\\\\\\\\\\/I0TFWDy\\\\\\\\\\\\\\\/Ty\\\\\\\\\\\\\\\/lyp7DZHhHhwmvDX\\\\\\\\\\\\\\\/fET+DxFqsyCHr1bJNhjkBg6ZIxfbX2\\\\\\\\\\\\\\\/nGBmkzFqCgdD0x06Wfw5eHs1rmk4nlErMx5ieUuyTIxnREt4DC9CuhLP109\\\\\\\\\\\\\\\/PqhTbY0xiTDHS+\\\\\\\\\\\\\\\/8f\\\\\\\\\\\\\\\/vDw7kfsaIq9fIR0mW2ZT2IuCsit1mJO3e08E15FojHjIoNy3TvSVywIujRwNg6+yO\\\\\\\\\\\\\\\/TOcAmGAYi2gkxltup1w6FHSgu090+tjDG3v9xqHe1ZbRpYWAeH7yri7UfuAwguCkVyRz4A7Pj\\\\\\\\\\\\\\\/nNXyWdIBM3IHok7\\\\\\\\\\\\\\\/lR0jNcJghMNx1hZ5lpnyg+CdII+POHvgOEWlOf05cGQ13MdbiFCain9YW369FE7KJEBDyPK5T2A9BRHf8NBBJE71Z7Zo\\\\\\\\\\\\\\\/TsnFWQhVLZsOAZEIrwb2pEOlBDsfvA+x2O2F8NxmoNe1uz6Chg2EsA+pVrlAWQncjJcWc1O8Kk1QYVFzMtgnNh5o4rNCeDYrg+blhuoFPt7O5l\\\\\\\\\\\\\\\/y4iYiMiI9d+vT6EYkxRN0MqoWCkrqbAMXfOeq2qLJEpEC2QwymWJHEfwmMaa5DJSATz6HCXo4r5ojgHg75OUtewlzTn3AGH2L3U5iWV5430AMX6gZPok82fqgruhSRQFM52C5qrGU0R2J6MXwjtEyG2KTohzGJnNDkSyTywe2gf9SFR14Aiw950hBWPmeFwpPwH6nbiuMsGdEDBqvZltpWOEEwba39Duw1sFQXNkn1OBKoY3bGfO9ZugVfp0Ra+WFQYoxNJ7oimuj\\\\\\\\\\\\\\\/prFRL096vc0qUcLfEumUTolTO81cpsAUnD5Tdb36kvdmKUwd8uTBrLpd5q0Hz9KQfW6oBJDkjUCoO+WvXrwtDf4agdLmKHpjKqEojTX84C\\\\\\\\\\\\\\\/iyHPW+t41HFpm6G7cJdfsQxZc7uqvB004wTqcd6+NaQ\\\\\\\\\\\\\\\/3i2hNTZJNkYZaqkGeo+I7D0oWntc4DDr\\\\\\\\\\\\\\\/32Z0Kx1sfr7OdRd4AKnaNfxt58z23wHYSEN\\\\\\\\\\\\\\\/CSOdRWAaXRHIXnoHQHXC\\\\\\\\\\\\\\\/yIdFWCX6XyDROfvxQPIlPpYxAPEvN51lG71z3vIWacPh1pCqC3Ine8BoLDVYEvUnf4lEizjcaFFO31fp5Tb+gfIoOjwVU4bCtxlPDRH2Zev6Q5G6vJRPCkFVVXWPNBFGtstpI5BD3a4yAqSS6kWmal9KKq4w0ZKftdHgFGNYt\\\\\\\\\\\\\\\/87PpnZwpO4Y\\\\\\\\\\\\\\\/QKE0js4gcTXQeUm071pOS9Peh14qoy2AFhSfhkVg6JlXIAZiahg1EKFsnEaaG4ZBMqCnIJLKLXkgqKGN09VrNiS5zUeLTYTUjOtF4b0GvDrMGRku+QdXEvKVRIiqtguh7qLyHNfqEfuCkDlbuo6x6IupTaYxibJdng5Erxsk6IsBIzWz5jOdSuCLWmK0axmdxXI1VI8MEeTc8r1socSfkVyFrhH\\\\\\\\\\\\\\\/e94VAybcM7iKi+FeEoqzZq8ACclv6CeJA1XwtRfFPa9ACNNPxuiXrEuWHvY0xIeWDz5lBMcMWh63\\\\\\\\\\\\\\\/5HLlTaaiziIPpg+hVchL3K8x6NVrd4WKWZIG+oAn8z6sPfO9k1hJc1auPQvimIJTbfRbfeHVl3DLt5mz\\\\\\\\\\\\\\\/atMKjLEuLGVI28PVLY6RF2pUB\\\\\\\\\\\\\\\/0h6qk3I+MaAAk4OBCRQwi2UXBU8gNO5Rq6zBk4ur0zuTjE6TVQsSx5UjrnbB47kZa9BfNtf5oTMhZFKnviGbm4560AsL1jgCHDM8cZIIqr+xtkuEqsVUYJfE6TAUhk\\\\\\\\\\\\\\\/do0y52nYvRW+xDM6BjgLU0cqwvMXtf+kHKiQzMzBv1f3WGbpJmBrJfd0Vtj0YBChwRi97yJGbsSwtJ8sMjayxkBKZoDs9Lcbzysi9P5qUE\\\\\\\\\\\\\\\/785k4nkhAMRrBnn11pH79IqgcaEOwcnetR0E2uiFmUe0u1+XoDzMJGw2YI1T+AGmfxTLgu8QW7Ztawj8zxDAvOc8GXNA6bZcoatfF\\\\\\\\\\\\\\\/hlUJoyBPgwFVjtpDPErttl+aXV241imibOnb9XkRKDzSIXy1wiZ7AmY+snDcRPWFg7RZaT1eXQxElsjoS+ZOPQNdozIKwOEK1l4OtVaKFYU4vlItjKwg+4BrUZxQICbtrQkFEOrtGaSbeo6+5GGxnxdP6eT+xdVl7CQsNpt5mv4UGW5x6Z7+0TJzdsKb34TymAgCXH\\\\\\\\\\\\\\\/FIcPAbhWnqvowYoZpTW+q6whCrgadB7vS8mSO8D6GgF3TuMG6vvPiurq5goEGP5gwkg\\\\\\\\\\\\\\\/FUC0NjU25fLJ3gtHMDsoHO4RfJI2qHiI2LydlTolFqjhy7P6IHYKyLTaC\\\\\\\\\\\\\\\/l1UIAk9w1HDfEVeuNqsMgZ917mg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jXaTSD5W8wUyuSdpSDnPHg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227608754133c82016273f647f3ef2ba11c4d65270bf089a6f14b08026b00618c3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006802.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006802.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006802\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006802\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006802\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}