{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wBmNrZ\\\\\\\\\\\\\\\/LcAGoMGWKPvO1mpJK7IINExQd3YR\\\\\\\\\\\\\\\/S1diiwRXVTONy7HMn9geeEgEHVkJkZaULkvlFU4wLLw\\\\\\\\\\\\\\\/SUTHfuJNkndJnoUJfGF0cuGurJ\\\\\\\\\\\\\\\/9AF\\\\\\\\\\\\\\\/c4iv2gGE+YjZ8SFNX0CV33nqVhUu63D9qOc\\\\\\\\\\\\\\\/UMJeAnN7v4PPGy5hh7jpKmJIaAf\\\\\\\\\\\\\\\/69R\\\\\\\\\\\\\\\/aTHAVfWIs3OCWFmctRfuddZDS+54yEoz79ot3EAXxMtGPffzRZcdeGz303597cxkd0dxNEa3eoVanGj6H8810n\\\\\\\\\\\\\\\/gNJ600AM6Os\\\\\\\\\\\\\\\/REL\\\\\\\\\\\\\\\/jBOhCencCnlWtzNH0wIu2zkWDGDYj2XZItNEhE0kxdqopsGEUcPcrrnOr3EUK9jqmD8FG7nUUYmEP+Qf8ZWokRWhTVC4MwFgVzflWiV7lWrXVMZgI9cUcEz1OmR+QsoWnUXgIrk7cPthSUSgTjZNOLNCA7+L2TfImTDHn+7uZqdK0I+j6Ie+oup3\\\\\\\\\\\\\\\/s8xzPtHPUpn0ByCze3TD\\\\\\\\\\\\\\\/7ATp4DYUs9C0sPUXSoIK92riQY1wib7EqYYCXzGxLrC2+2P9CQFks9SPllLxnTY5bP\\\\\\\\\\\\\\\/ICx7rIi48zjErr4ur\\\\\\\\\\\\\\\/KeMWwFGhkR7RqibHcsdMqwMe+eHsM+1+E+DeWTVHdjbt3jTKNf1LE\\\\\\\\\\\\\\\/pxxkfGuscF\\\\\\\\\\\\\\\/RkGZCJDHSTFHiT3y+4RytTGs+qXz8HoplKqDur2fw33WPT1Y85Zb5+xbdTyzJjL+6ifGHyS5MYHzL7IEJTPBOv45pds3JYCj0p\\\\\\\\\\\\\\\/Pqw5GZaRkSTp\\\\\\\\\\\\\\\/X3CUweL1FJpWZ32hnfYnh60nmvpPAgIYNvJpRYyESgLLnC7OF8nURGLN7m5vTm\\\\\\\\\\\\\\\/XvMv2gSW2zZWX5MhXPQZ7XBot23tsl\\\\\\\\\\\\\\\/7R10huIDZo3nnLQIvDSzpAsFhdBFydCTO9yjjQ22Qleh14qXw09SoW9thzwL\\\\\\\\\\\\\\\/4sIQ0hyvaG88fqGirCVGDDizhDyHM\\\\\\\\\\\\\\\/+xe0TqJ+FwmtORfqyjzWVsZso6tqDXwQf3KvsrfhsTt6dioH\\\\\\\\\\\\\\\/KrDzn+XgpPTCUoQ1riAAfflOU1+RJmqxU4z7D0yA7H3MuP4q8amQgE5DA36ye8+89uIk\\\\\\\\\\\\\\\/pDIvPA21NYT7dOFWQTne6\\\\\\\\\\\\\\\/ShO8KmVVE8OBCeN+0oUQylRskl6c5EJJdbxtkNd9mB8jl8QQEZVTNc5oBMgH1wneRfPoIq3bDRtSzNcxUr7dMwsTduk8jsAy+DcmrAvhCER3TOWOh4fO2gcflv714NNYUFv4NOihsgTNq4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/C8JdxorMmQCOcQbpZkYI\\\\\\\\\\\\\\\/Xv3fz6rFNrwmn0Jg0tXNlo40a3iaDZkrPfhTjs4\\\\\\\\\\\\\\\/+ng3bCccXjvturhEBQfiIengSlj1eslXcQ5RAvcSvqdRcXuotfuW2ioNTDPvqnjLIpcXGeXJ9nNDcQDZ0TRuj8hR0cFVjUHKRyEYtCQcS0dCRbRHasWvq7RgGhszXp7yw2naK4ulCaqDWbnYtg2TzDkbjjrRTySysUtSko2DT2Jo804wEvf5h07Mmr9mw9lyXVEQgKy6LqTFP27WE6\\\\\\\\\\\\\\\/be1N\\\\\\\\\\\\\\\/x4y\\\\\\\\\\\\\\\/lhSZ2snJEBJeiP9RMmC8htCyNRW6LOHgSzE4m1clPKBwbxhudqSrFX5PgeO+g7yf1PcoSLMllitQSCG3mM16g6jIgEHNUWQ9zx9fnilU15JUbbGAkD8Pl1S\\\\\\\\\\\\\\\/a3x1GFChu2b178YEz7xBXwT6DzoWMyWOhYMwtUdUGmTKfGZt45beqeB7KiVp8iBjeDonnGjYQD2jZWipCOUTjIkNOt0Av2vlNYhmbIuultTI+Izl8jU2fnvWwF0bsDhCLDEwDcu1Tl7ss\\\\\\\\\\\\\\\/XS6sD5kKwOgb0QVhs1g+aGQKoe9tL7ThNuGrqJfaeFVjyH4fvxvEDbsIS2pzeRy0hlNKCK0QlRo9ej9Hp3EPHDfIXcTouxPUhsCCDFqqnCQN7u9Bhqccf7uLw39EtmRJzai1xwnK5HcQ9\\\\\\\\\\\\\\\/XEcJdQUP6FRD1zTbl+rT4AgvY09WMXL7kuuYyjk8ToQqz76nROrVqbITp8fE+tpOtMIj+pqECJW4\\\\\\\\\\\\\\\/CsqykvvXaccxGBQTkhBdn7l3fIlbrNv8c\\\\\\\\\\\\\\\/o0c+E\\\\\\\\\\\\\\\/0ecliuqfozlmkIdBzMkTMNs+YlvoWK8V9IbYciJ7D2CsdOSNZARFkqVhpSRkfzYuZ\\\\\\\\\\\\\\\/YU7aK\\\\\\\\\\\\\\\/a6Dz0s68sz1\\\\\\\\\\\\\\\/m1ZBx5BFIYSTiMRDmOhPGMIXcapkcRqlWESQh49h+DQp6VfPaTm2llBISyc\\\\\\\\\\\\\\\/D7acogoIdJgVo0Q2DCqUBpKsKVEQ1V9QwyJelM0p6psbvW6mVoIrOwLAWHlK9KnAmLHOKjYdS5kt3DjCEixIEg9BB4Bp1q9VaPMtylf2YHaRR+TX2EPQsQc1PMqJg7MR5SniByAiTB52HqYpBdCmMd0i8J1CfaXTpDjH\\\\\\\\\\\\\\\/YVmRnV+zEiLmYvsFXp7JoumWJ9tgb\\\\\\\\\\\\\\\/u9qcvU4pQF15jB9dkVhseMpp6O\\\\\\\\\\\\\\\/gArExw2p1DuVTy5Ya+x\\\\\\\\\\\\\\\/yzoRS94eLR+GFd6EdnRpZGOrh8sSfRhL9ZRUSUIsDwP5onHbSgxKejut76IpjZxsh6lEXc+c9hSGM72NdXDhhWwhQVVBM3\\\\\\\\\\\\\\\/sJj1KUz5X5n7qYWgflJbNBGs0nMTP+EQxRnGBINIHzxTbnf2xwNddsYsCtoPLnflm0QvtbSzSLRzbcAjoU3iCHTYHg4G+HmjnFjbE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022k\\\\\\\\\\\\\\\/jFrzl7N3lh\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/v2dbrAPw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227e3437fc88eb605e7500dd9741541d138f1e3cc3fbb101c1f6d47a643231b3a0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/6\\\/e006654.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/6\\\/e006654.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006654\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006654\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006654\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}