{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022epyA\\\\\\\\\\\\\\\/adlhvik1swvycAVJ4wo3ozRXqdDtSUtXekO3wk5EGPA38Cwn2h5x1Wty3X1Lvovozm9tklyvI4u97jthi+py9uowz1t7nzkA94oslbJE5SdwS+NBkIG25WMz7Dd54+B0gmkst6ifd\\\\\\\\\\\\\\\/cpiosFvxTd6dlQae4UCtc4XBECp4RwQkq1oVddJAqhQPvZRB38\\\\\\\\\\\\\\\/l6tyuRCTWnRoCO+zyfVmQ+RSIIDGPNuzyYr6i1DFM3zG+7HIj1cK4Jjdn2plvP9r\\\\\\\\\\\\\\\/ypr5HQdqiRaFx6QTD7TffzEbvqTjh14P8Qv3NScr0uqaqwxPCfxIyLeIBOiikzfu38OXju0KuetflxyhOOa39fvd7vqHMLUo3g7H+\\\\\\\\\\\\\\\/y391v9P3Jx852wpLwmpJoQo0TViKMresKMbCtGs6ejhP7mFck2Yx2dI5mc4c93Jf8dBrWuADGBXpAvUdZoXuzIOARCN+g6jMs6RGQl3xmr1juMBgVGKMak\\\\\\\\\\\\\\\/sy9EMhPAmUozy7dAE3UUEfSaCMP4Py3E7gNCSoDeQ8ZOmHrZn9VhWOw8TTKG2Nwz5UyK\\\\\\\\\\\\\\\/gHYVgjnVPqLNDzS739Y8DO19DOoZP\\\\\\\\\\\\\\\/M+T0t4ccy0575Em7sgHO9m7tpwcNVZsENDVbVk5WPpTo7ZZ1nkv21J2E2CpSAocFgwTg71v\\\\\\\\\\\\\\\/TrR16JE1uqe7qqg8ntnGipP5GZkQYFG+v5+XoCa6SqKiFuoVwYq2ZPTN4ExTJx1slEddLut+ZqJDrqn0sypqPk4MougJCNU4xVEVplrlFepb8SLqFcrwgKXD2xDa2bICauFlyr5QFaBdIowr\\\\\\\\\\\\\\\/d0spwf2SlxJHx2gdOE6zz8j+hVGq8vsoUsZ9Adt6kFSYDuGglipWeIAdhZ7s1DYl0XoYyIaGojOJ+cdr99KtjZfNMzHANhbwC50MMlz4Bmdb+Sh11bbgepsZ9eSjb5dZ11HMQ2M7eukuGcyQL9uHQ3p+wUHSOxrM\\\\\\\\\\\\\\\/z2ChjWlsTRXJgrSg+yAHNqwY2bdypJwOZZB1jF5itVrTP5xynuXYgKc0nBWZ5NPAPM3t6M0Khvzc+QHDoixRJHiwe5w7qS0s7sLRYkPw\\\\\\\\\\\\\\\/0AMlwS8yLCcAGpT8MnKfinJsezpQHz5cLQ\\\\\\\\\\\\\\\/MA1UcDucu7fowaRySKzNeKxBLm6MCRIaYUqpmDFF1bCyNsvUncZeEp+6jAx+Hf7vdCMz6cBMMdESzAjafrxeB7w0see2B+z+80DMkc4YYLABvtmYudyYTrdfu6H4D41RxLXToMM5OzsVgg7A+4zf262v4AteVlF1kWdbRQTsg1FB027KAM53Dtc9ahSBdM7Sd7frilJ0j4H4KgY87vh+x6wO1j7ilwl6yZb8KOFSlXfIcnWBHe9Ha7QxQAq6RSRbKonORklEIVjUd6zQnRDU1YILWq4tQ8mrQ2EQjVsT5R0Hkl9Oq2mQ6e84dAJSnc\\\\\\\\\\\\\\\/bmfV2lA4jcEjJHjKaOxT\\\\\\\\\\\\\\\/F1Yt96ZDFCwjI4hu0lB0r+kQ5lLU2l5SO0tmPkIbFzSdXWua3+HhdEN+Yql3Zl0wNY8OD2Io5aqa\\\\\\\\\\\\\\\/DjDwRlXS3xkCqe\\\\\\\\\\\\\\\/JgCuoieIuAibyA5hpYe8MFQepjNqUmVkGkGgpQP+5YRwb1HllvYFqkLlC\\\\\\\\\\\\\\\/BXIxaf0rQgDRxwMEXG+lQYTPMRz8YomEtk1s2QGFl8+YHm+y\\\\\\\\\\\\\\\/PJ1MrYCjLzRfqfpzxxmnu1A4IWySOIHrum37Su454OiCmhGuGdmgG1LwiyRJYHIHAx3lkCpEfag1pPNMUMxVoF6cdNfz\\\\\\\\\\\\\\\/xVhRdXA29MrLbvR1sztT9Nq3gtpK0rFPSvdgFqgmLsJ9aszeLbOAV6oXscBH\\\\\\\\\\\\\\\/k0l1VM0EzLOJUm3gr0CT3SEXxMQclLD7BNKEnkfZtQFWYaHDRZRbr7rOLqCoJ3ljoBMicEVVqJ20ikv4ZydATsTfqPgGy6+3mp9ssXUJM7d7060liq3qLuXMWDWVZYgR0hJq1w4LTjZYlS0cR4Lq8xOw22\\\\\\\\\\\\\\\/HeqVv8D24oMfsbY00bj0gjxsIKkyVu7smjed5+Jyk0p4ndreEfHGXIPP1nMcu5IzOjNxvPRaFBa\\\\\\\\\\\\\\\/eTvMIlbzjAwFdwrwmYre49WKw2sMMiZuNrrFBAu1v82rx4441v9MDYrwWc9oD1J+7N5L9ww66ICQ2Rbi48QaRCUgqDJApgTcbOCkNDQKbdFt27C2Gi\\\\\\\\\\\\\\\/XtLuAoFkpMZikH+oH0+mDXJRaR2Df6psGM2V4aHJMAO\\\\\\\\\\\\\\\/bO0yjBPTv1c0yT1q7M1LS3TJwshCqzqApS2aluPTi4o0XYNLO3a4cBuaO8qSNGVymX1DD6pomk0fEQSGYnjS7GpqjfkfT1K5zseuxcaqx2mXzXjfavcXbYN3pZV1rt32Q+bS6NDD6VIPxvyD3TMUVlw3DusrUYV9yqpMRaYq8QQoGP9nytqQa6e6cQ5Nm3\\\\\\\\\\\\\\\/rTsbRpzkGsi4gjFnXhitVblR6a3qwbs3qzI1yfu9hl+JUfu4ywXXMt\\\\\\\\\\\\\\\/xeweW3d2j9TSt4gZz5\\\\\\\\\\\\\\\/Rhnyw0OzMzxCyQaLZI+l1Hj6\\\\\\\\\\\\\\\/22PVQ5HdsQ4NcUUmbGDF2jk9BVERRiO7oebqkVtt1fOvnokzwezX0rp31qCskk5HIPcL15ZZYy42UHI36oOND2ykHUGmIhSWerZNED0MbdVP06J2ucM7ZGQJvoqVpUzuggKvY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022yYwNxBVp2sYBEOTwK3lY+w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002230315f60a6d46ffc9fb0dc6b2033be0950da6d3444e005cfb34005de0f6e2e56\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/5\\\/e006264.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/5\\\/e006264.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006264\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006264\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006264\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}