{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022+hNSOknNnJxoHMH66nNX+0k9UPNnb7t2fhL6gYNLUg83JUjJSdVeC0ddJiFYCo6ByZZsjhQLChuPlFZcJtT4kpiS1vV3eEFcHNSzW5OkH+k56jVWNS4khjCoZ4EOZ9udJcGyLOb3aUolWwwYXc0Td+oj3WbhK7eSRmTN+DR0J9ojVhH4klxTXIcN1ub\\\\\\\\\\\\\\\/emP5HIsSAgkBE6W6AxMEbrNkfrnAJxaDKXAzJcA8UEsABESIGM4c6iU8fnXkxMVk7RuvnWjUOvho4e7GDAiLnYxTUdm9AqntSY\\\\\\\\\\\\\\\/QZ8GttrC6FWs0FwjBVVSwFqXrry\\\\\\\\\\\\\\\/HjthIqMAJIHYi\\\\\\\\\\\\\\\/Sq0tBS+r11Gqp3Q29HHNhx0D0Vfpv4Du\\\\\\\\\\\\\\\/pNVhIU6rbv2Di\\\\\\\\\\\\\\\/HU33YhfuAbPKyox418bUcNn6+DuUuZzZmMTm3E65I2I2d9qEu5IpD\\\\\\\\\\\\\\\/VNeKk+EM0TlGTdM1L1SAGLmWWDKepFD\\\\\\\\\\\\\\\/TrmV7DSPvpS4wF6tTrEd+fgtkyEh9vPHQ\\\\\\\\\\\\\\\/qnW2Igk2xzaobmiY6BCm1swS+dwDMPIP1peEyArbzVWfLR33wLrPI2ycKrWw1txBlZ9TfHrvP3gMu2sit3q3u+G\\\\\\\\\\\\\\\/ijbKyT7L5UliA90DvSdsipy4U49GGKWgewSU48e24njo5d\\\\\\\\\\\\\\\/MuJ5mbZwNPEA0pByfMVyU35r8Up+ZDP\\\\\\\\\\\\\\\/KwcQNEynOLFvcBSepUb8Pe\\\\\\\\\\\\\\\/bnoqmxvdY129fKQjO5ZoLYWpjrK6HCTaqdU7byIMjOB\\\\\\\\\\\\\\\/bY9hTjmWnTIdgGO7vT7NJYtpJfZ9ufLG5+OGFiDGID4t8BxumKFK3XrqH7JpNYyhkNcdqFXFP1JawFCPYp6LzxJSEh64jVNAnLgaV4gcwCM1SwIqS5guaneY3O7\\\\\\\\\\\\\\\/AzWx4PeM\\\\\\\\\\\\\\\/ueO3DV5PurvUtjzEkUQK7NhCvZHFL5f50DilKx9cA\\\\\\\\\\\\\\\/gqq5RrMXEV\\\\\\\\\\\\\\\/jI2IJkjZHPnih4srKo77UJAFxGnghU38KPCOeN1UwGhDFMSc0qFCwyj0\\\\\\\\\\\\\\\/i9SbROzr3dGQ3dnyVu6NIEhFUvXKjJCf+7NRgCq4CmIh1q7Rtqy1z+LVbT8UtMPJnjHM5ZFvglJP+BLAfW4gpEljUyLQAEFftOukCUgPbl7WGs39jUvt03G3JtFNhdeyQxc7lyb2ZhuYEyTOaCUoiFyI6Ghi4RNcJYihCr81r2y\\\\\\\\\\\\\\\/lIlPv\\\\\\\\\\\\\\\/3vXN3ctJtkiQqE19xV9er0xkiuMXCb8FfLBm0MxdJ2rHTaw25tnEFZP56NCS3AXDXBbnHuOXy9OiyeNFzEan04VX3hclxUPxWiWYlTeLvYbxJtXodUrZWdYLPadVR+seyUUKamnkrauLQEpHw0DFzCcWXkXnvOfE\\\\\\\\\\\\\\\/TIgQa3+d1P+SyMjzIS+q8Nrq7+0HyGxGlXt5wFjZxyFRrJTHIc1ebT9b5WeEynoGnWm8C4FSMuvZTsZZCtfQdzlc3VJdYB4JfF1Hbhrb0A0Mu4H+AvJfITk2wuwMlUvarlNQyCQem3W58yMi0glssdOF8MbmC\\\\\\\\\\\\\\\/ju1QSA4nnbo77e6HnkLLSp9o5mVH\\\\\\\\\\\\\\\/nRf4ekHy25Ksqi0du0ezibFVJSj2Ua3zvmUTHZ8gTC6tuoiDGrOsG+0ByCf+E4iNmU1S2OWI2eY9NsUqNCJ9mp++hLN1ihbfPfUT8Fi4T6BNw7f6T9uYerveD1gLSndbsqCTFVZEOsPoodgvzjSJwgxpK7k26wexNpmuYED8xokELuCx8BHA8sWE+se0WB8R0ewbhkFymnL16Yj+AOo3TJfIN9VsVLnBVpJUxEju\\\\\\\\\\\\\\\/Bexl4lXTV57UnmEjH1VuCa\\\\\\\\\\\\\\\/AfWN+V2qWTXIl0\\\\\\\\\\\\\\\/Jdy6qWAoG0DwjXNN2cqjsXQH9HWSZuSXSmqhiOwIjtB9IUNdT6rki3edbSOtGVBMB+J1\\\\\\\\\\\\\\\/dwQPyVXF5rqI1TclzzhcLwD3ogP74ITRW\\\\\\\\\\\\\\\/6dFOQudNuEC4Cm4jITmY5uVCRv8mE023dmCyTqbovP9kNx10zkOaQ+PA0OEAF3dHSVCzeKSNLcl6IydEsHGz4kgb3M+6QH10ytzAdrS\\\\\\\\\\\\\\\/Aq+MVkuXUfHaOz\\\\\\\\\\\\\\\/K2P18XElLfy7FYL9KVbHMhZFaWVZrKzyxEYp4eeHXnQAZFr2Wye0N4SsXfQQomSxY\\\\\\\\\\\\\\\/2GFfADfEUvgxmCGCpdyiuanrHSkfxfudYUzWFgT+OAWc\\\\\\\\\\\\\\\/auK+pM7Jf8QR3\\\\\\\\\\\\\\\/ChDdrFUicjYgjk+AzNotWDb2nNWYMX0gMtQlzXhz8jBWdiv54IhUZpQLjB8a9yGcBcnR3lQNgGz6EJvGe3xHgtGmrAcFfVL1oGmxjRJFltO4i4hFEzSlriq2EBQIyoyGluXzxsut4KWDejPUy7E275rgsgbVPcoO41c2gMjwCckJNO\\\\\\\\\\\\\\\/qbq4Qga4X+ld8gNq1hUHUhOyNg36HvYk4luEXOstVybgTXvPf6xilksz70FJSgbUh2yoBsAhmsQ4VUfQcGTE+VSODX1GAmR2YuAhYbf9tqnHP8Sj+U+ThiI5EmqQNszf5BDqxObEgyDq9gP1vcJaNjpBjbdIybW3FCDSOC45DtI+jc5Alodm0boyuvaS4XN\\\\\\\\\\\\\\\/ewVw1rmy3J4v5fCm4Ndj5R1FmAHS\\\\\\\\\\\\\\\/17PPkVR\\\\\\\\\\\\\\\/sDzPiHsLWzvoXY1Jpj7sMyWAIFLXTwpyxMwgQwDsraRC38gy2GJgQk6ZlpGKWbW7mhejMbMSKu45\\\\\\\\\\\\\\\/ANeI8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OShJBkMtmxuBBfpzN6eJeA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002246558e302822bbd81d1f225c5dcccc0e050de90ec63b81e4931a851d01569092\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/5\\\/e006230.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/5\\\/e006230.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006230\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006230\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006230\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}