{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RhVQgPDlT4awnCN2smtzGCyiPuLd827fyo13XxhxtJpgs\\\\\\\\\\\\\\\/QJd6BpA9bwQwuoHxvU1XxTz+0cEYUDuDyLODiGtM7ySeaM8kl997oK4qR0KiX4KMyVRom+0SyNJyuIBpMRQi8lHf0oAiBQvmBy\\\\\\\\\\\\\\\/5tBU1+KJQMvjuvhH0VKxsxQSd1yzhdYY+vsTBPBo8SL6S1\\\\\\\\\\\\\\\/RwXjs+WWaV+62lY4kAKnptl9FUb9w7IrGN4rVd\\\\\\\\\\\\\\\/Umb4RWM\\\\\\\\\\\\\\\/TWXBDtTQbXA0lYvd988UvRoG5sZ9nHGR7wy+tXZSR5ZpFzTU2hx4hhbrGIgeM877SEIv7KAq0qqRxl6dK2n7qn9TSFai6OsnDUDPjy3v9YWwZuYr0eEfEtEcmbFh9PlXMnUsiB47QY9KCsZtvmJZARRZNJ\\\\\\\\\\\\\\\/ZkwKWhjuCi7PhqlkggZY2NFzQa+DjVHUHmYv5xXCOdYKYcKCvwKLzoFIXrVby2Yjsb1m9bgHNxkhHYVTgNpbKCaEASVC8XW43wv1QXXwuSL+sOuoAlDF8GMdigB5YWgmNosbvVMgn5l5yVnUN+Rl7WO6DX\\\\\\\\\\\\\\\/X4TitpTuj3\\\\\\\\\\\\\\\/6iPpuCeA6RGMUogrPzu6BRDNW5GbpU4hYTGVI6inUosSEEpuZJ4FbtLvw1ZflV8qYAYexLFzWl5zdvn+pbDkQkRGp1EAaRA57mazh4zB5XjafwCaRBT+a8mDUTeKbWP22f9zsfty5AFV0M1NNBoc2ha1Ft2qigiOG331+2U1jgdau\\\\\\\\\\\\\\\/0K8jbEPqPTpUwGFcsnq3mO8QpP8ZR3ZS754wTR5J8h1uRmHYz2JVS\\\\\\\\\\\\\\\/phgpWYtaSRFo1NQ1dL0HhMGDykrUl36cnjt77EjjY3+mMilOq0GjPeH2axax3lRIK+opiDPcd3GI96k+Cs7eHBnJrQgSTckTpVSv4SegxLYYXSE00\\\\\\\\\\\\\\\/B7XaFDQk2dbrZAzTmA5x0cqJJcai+iK\\\\\\\\\\\\\\\/o03z4So\\\\\\\\\\\\\\\/fCYhWAXnR3OTL9IanbahJ5Ng2\\\\\\\\\\\\\\\/UpF8MwKZgYhO0WnnX8YU38lCvrBcwZ0a36ir3iPxbHmonuHsTHzU8jgeth5S7bw1HKVBLOJMA7ZjkQrZda0Plz0TnxfcepiGRVa7WyPCSOKv8G9GiJ4\\\\\\\\\\\\\\\/KzHY8RYfAzRZk7m0+TK7C2XheQBRQeO\\\\\\\\\\\\\\\/xURmCSGinsKkzwSpsqHSTZL43GHXdeKEc0Skw8+WblTxs+MXBwOrxy6QlpE\\\\\\\\\\\\\\\/8i9Nt95mgoOwK0qYCEHjBWjEzltE5Hv23q+ZbDw3nkCQHHaR4nSBDTnC6C0mR2A7RWhp9DNwq32LDggnp7up35Ig\\\\\\\\\\\\\\\/CDpv5qjtOJvZZNuK+oh2xMCMugcb9rx1rwnwsolKEWE78iTU3QHD4FqMU4Vc7WnA79ev3VuuNW743t25v8VLnKJ8cX8C5ODy9wO4ZJmaNlaI60KYnZAKXBvgJv1u6QctnDame+SMYcRqMfJykrkb0bkhbJ7BNRGsYQdFy3v20fToUl6vPi1Ei6z0Jpw3UMJQYptmYc\\\\\\\\\\\\\\\/tGaS+0cM6cxw0LrT6efSb414BnHTYDfUSEP8\\\\\\\\\\\\\\\/9hI16lVaEAdy3h66S0VqPpBjGxs9Z1BE\\\\\\\\\\\\\\\/YcM0Pvwc9C2Z0BmpFx+ZUs0TyZleJ5lwvl60L5Z2hyNHBrirVJyTHsyCkurbO9mSoP424O8PhfV7bORpCXogKA3fvm3\\\\\\\\\\\\\\\/i9CAhNShsmzrkYvoks1E8Me\\\\\\\\\\\\\\\/UCp2HRjKKDPOquizzhnCGCYWykFEsfvspXc6few2bQJtrKsIwJXF9HOb9pL8ljAqumptgFXSD\\\\\\\\\\\\\\\/VygyuxW9gW60KNO7in0ZEx6px+eAFhSncckjktDR9KTHAjnyoZjIZ1xvrrPJ\\\\\\\\\\\\\\\/wzTLi3ZpHfsVSFG8vaerGvzsfhYtK0zYMPpUecWa1H+k\\\\\\\\\\\\\\\/NvNniOBNu0zDK2I8KaiaLAeXLt1zHAw0TSHP6g8JaL7E7J\\\\\\\\\\\\\\\/VOkz9JEkFeDhngTcZQ9twKraPHHgnFiVNgue8Jrx8xPAGcHld1MAnq9DXQLO1GwIqGyK\\\\\\\\\\\\\\\/cd9weXv6J\\\\\\\\\\\\\\\/K2HX8nPkWFz4eUoUXY9Thx3\\\\\\\\\\\\\\\/41EuH7tIxqGDlym0awM9ke3G5a6j79xNPM7o7JXWCYw6WL1Ph1X5aAn8aYtcRAw8HrmAAUhZx38N\\\\\\\\\\\\\\\/W1NlZjYl503rZ+3cmjQdKfJKwvdtvC5+mDtFUHdOKgFT4eVRjLxwv2fvq2Z+0v5qfuytln8W93CnGQogKWEomPvaV771UQ\\\\\\\\\\\\\\\/s4DkuDDODG2jnp2E1PxaN65aUUtXVlUjDA+ngSFaU26Jt6upRRaFzKomk1Tx3Yi54D7HIxDG5kVEILokCdQpAJ7+y13Smnj6PwH3083xbaI+Ve\\\\\\\\\\\\\\\/0N+EGK1lMnD6daBBYJrRAuzDPJ6ZdobPkGA03WbnDltpkN5zqBhV+1s9HsG6qLL5OqPFPcSPY5iI5q6NZZloYTBr3GFBWR0Aok92cRP7tH+SfCenROUztOLOKBNsF5d5FAlgv3h6chKOuByvppLiDzROWWnCFkscR6OsQdS9doiss1F4MXXeSwSMr\\\\\\\\\\\\\\\/RJsNiV97+DAMFWWvEwWXsJYR2IoG3rZLDZXi48JbsWCRu99CS7+WeX80XKBS\\\\\\\\\\\\\\\/reYlp+iO3OS1GdGtN1zE1kSvJcoyDS6RqLQloNbH0tPPLDlUdA0s492d4yzZPZg+G\\\\\\\\\\\\\\\/UiGdqEicSXwf3Ds0jgY4+P3amJ4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mRu20qlL0ctYxqJYSiiAMw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229377d9af411c3e2bcc705a76577711a226097fe37beef81737bf6ed6a9d7d803\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/5\\\/e006714.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/5\\\/e006714.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006714\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006714\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006714\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}