{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022xlGRogKlOT0IrJs1oENu5WixGA4JDfIa6oIT1WJkTykTYtwdOViP6lQwEIwdpO8qcwgCYVeJ7N5dFHQ8vYn6UqX4v+hwgZDpw3dCLSkN9QPldfNJcF3N3RRbYBBv4W21MqTFcfEJmFHc+al8FnDJZsgxrB+MTb9ysPANoBbOcdqqEOjPOJa7WQzVSFyp9hGfQapmNZWu9mCbCN\\\\\\\\\\\\\\\/Xo+TTdUtdZmVzY47z\\\\\\\\\\\\\\\/l363v2WVTSODlCLjf61XDYIJ\\\\\\\\\\\\\\\/KQzlhx+qkAzjbEbU5KpXDjwe6GtRVBr0QuMwe9Lg4f2GaEJXYd5YG4VVvkgZiqE6P9lFaGg4WZNXfmHVOhOFdPSC03wJghbsMQrYJXzjaImZk13uCT9ftjSu0AXfkXpMzUlq\\\\\\\\\\\\\\\/DqADInyv6LyR3R+V4DnQdIi2Y9B13TyepDXVF8TJgdd9Gc4URdTk4U8LLRqrX3BQTysgoQMDRu+83GE36EyOos\\\\\\\\\\\\\\\/92hKOfVeUWG0ZyGOy2WVwHEEk1Zq1y5qa5H+fYlGqeopqVvhiW4Sc6bxxI391+KYNUSDDlAAa+pPMZ0p1FOAJBeIYjbeYA7GpdeczY8jc8kCxuom00C51dqeD7eR4loG+ddbouQ2oNPAedTMSPIiKyepJFfjuopTe\\\\\\\\\\\\\\\/VBa9WkcAJq2mazJtPeWifFzOWdwtbuF5ThBsLXRyY6P23X051NcIMVoEI6rty+ZinX6Z\\\\\\\\\\\\\\\/ZH\\\\\\\\\\\\\\\/Zz1Caf0l9FJOc5ariSpYYBmGNw5umMKaa3HjU1ffJTGTRqCG2AUVIbIVjlyxSxTFGFLpw5NJPy1Krz2ZG0GKCPKirq9LccaeS22Y8thCfcz69SzXSOWsR4A6hQttz4NHDraGZJ4EpRjaRNkbtBkefimGXxSn8yY3FKc4R3PLmgGRehv9seCNkA1bGcfLzsoLQygl924l5a9WxWLmdfMkpZWsIqxafk3OgKIzRGteopJ6TCSfqFMU73f21YNR1z6rkfe8YsDls6IMmO2eXlSb8SVfMqvFrX1bnNypS8LcvuGVQcJuBZAu77QTdW67RIlIZWf1cUklZ+dYo7qj9fd+Dng\\\\\\\\\\\\\\\/RPIExWi8JOgyw3Zk1+KFbCUMVXoV3gCFVCLJHeWfwpvozPcHXuXWznInygC\\\\\\\\\\\\\\\/onIkdg7b3PK4V6NIpSGkfBn3+iCILbKeHesss\\\\\\\\\\\\\\\/WFUvcN8rzBuqZGwoYKo5b9sBzzjKaki04rVf4fMWy9hZLIOyRGTy5ivBPb7COJK94oR6wdR4AduuBVMs6VczK1H2tgjBUMBFvkQVsMA\\\\\\\\\\\\\\\/mMD381gcb1s6+4kY1\\\\\\\\\\\\\\\/BVRKpJKHzGBquJ92yGzXXnelWEYJK+drPkL26ppkbgT16ukE5l+CSfw7jSA3QwNxBnQ4zQJnIS44bjrunX8gOmeS5+gmjJHM7VJpfHYuiQU1X+i47GJoB+uQGmXE9PsFWe4mkX3zgz6vv8iz5WFtz8ZCQXjOs1e57d\\\\\\\\\\\\\\\/c5aKZCVFVovvDz4R\\\\\\\\\\\\\\\/ocmWsu6Rh3g\\\\\\\\\\\\\\\/mLlusbOfB7h9cpS1a8yR1eM5UDzS+vd3w4gMmpIU5Mmxd2m+PDlLIAjM80YOK1B4eUsXhI3A0uoRFG3fNvppWe3dtUhvTc4xmUeF6+lzYEYsTSgZV\\\\\\\\\\\\\\\/EKGPkc2Q5dumS5JXyJDxGXJC714quRAnV88NkZ5OfMA02zd5SgfH0YHPob6+Iif8zq3WGNpH5A2h4n6t2xgoJjcFyDoMHtAQbqo3AMycD6UsaBiQ9qcjrlJb64gFjQzooLrs2GrS5Z+6XUdpltlxAHw3o4sLSZnH8H9997V6sPFs1sMsHgpu\\\\\\\\\\\\\\\/MrctAPZxOeaDRWRq2dQZVc2hvB6qkSV3Lpg1mJ3kHH1Ra+XBjyP12BqUlyePIJPIKjImHvXQyhZA75RV0wny0JT140214rEkbx16cxQ60XpgIehqLiBTTM59mSMQBpEGF\\\\\\\\\\\\\\\/DctqQWPY8cXTudNovxEi8E8tuEIe1QJABUfPDaoUFbglBh+2iFcAitHu\\\\\\\\\\\\\\\/6KmKWDV0hp2cEAori5h3lvFzO\\\\\\\\\\\\\\\/LP1IdwX7XAyEsR9hPkjdRCyshF2J5vrS554Ofyvmj248873TEkTFArb7axjCD+1fZJc6dTkHCKcCHRfnddVYnCu6EH6O7+PVsXY0ol3OXWAxmxmxYPdGaIYD3x4iWijhWXvSJP3IT4cRvP8G6uW1qsVEC6vNcQpJr3KZ\\\\\\\\\\\\\\\/m8Sqz+oLpaiNfvZzQAnSrWjJcQkZL6BUDqmQtw1i9LHVgo7Zt\\\\\\\\\\\\\\\/wUoFjaCoBq3B1KruHH926HTp6X1ko+INFGxgsC+McmZQ0U2Lez4pr53b4sN0QIsXWA\\\\\\\\\\\\\\\/mFZslwwzif+WSrNLHWftozMRA5AbKB6v1SNP4x8iZumoL\\\\\\\\\\\\\\\/yobXcVXpvzPghbxjfBs6aXQ5VMHCiCKaGGRuQC+OjJfixXok0VDL+90RUFxCoLZG3lj+QcMU0sGVhuC\\\\\\\\\\\\\\\/5uOIMQ4AL8vv2inEYNp0WVzvq0eSELH7DP96Bzvc3FPe36SLqG6bkMWy65hukwNBKGrEOjCKQc+TIvcEZKHYQETmhYGi\\\\\\\\\\\\\\\/+VrdsTAQuoglFBHuNpT+yu\\\\\\\\\\\\\\\/JsL50gK3uT8+mjGgfN51Em2k8NaO+H1wPrJR4YONlvLByDEBa8U\\\\\\\\\\\\\\\/176M7+FqwJO10M94RdKzB2z+GYVaRdFKdot66D8OGnlqUEXFyY+jkU+m4k8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GzrRdnaeL4uVHNv\\\\\\\\\\\\\\\/GzmnxA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002280ec3b73280bac28d17d70f97eaf23f53574b3e77dc2e85a862a8a6300d07695\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/5\\\/e006618.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/5\\\/e006618.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006618\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006618\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006618\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}