{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022zF\\\\\\\\\\\\\\\/5dseIBUSodl39HG6rLjaE88rBI\\\\\\\\\\\\\\\/NTPtQHV3\\\\\\\\\\\\\\\/SLi0lxbpQgJXduOpF7LXFZJ3n0DpnguZf+E0ZiQNHgoxc3NeggVzWmMMBs7th5fBTJTIJ4QfdLBfzWu4bQ8kmZM6A7HOvGr96gjS4cw3dJzvkXvJlyB5+81BojS3JEfBHkOyC\\\\\\\\\\\\\\\/N7Zvf2wkW48vbvbiKmuLMEzNitXJmwuLe8uj2DHbTWBb\\\\\\\\\\\\\\\/7EKeFLXWnBOBHc1ZgcP4tN5QuG5q+\\\\\\\\\\\\\\\/WKUdK+5T6W9w8PO9cw0SVHKrj5DuoI8e0dmqzPxemb5z1PStBeanBEl7Z46DCAK5APd2Rbun7tC+MCYmM37m6tjtuZo0G\\\\\\\\\\\\\\\/HDIFU3rt98m00yTorwTGETqcRC783CaKoI4\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/FzyjdTEXkdC2fUrIznaJYUnTc5VF6Ugd48\\\\\\\\\\\\\\\/Ms9AG3eOCEpDp\\\\\\\\\\\\\\\/73y77fPG5bOF+WfLCnKzr2mFhSumDaTYkzZKf\\\\\\\\\\\\\\\/4SNVqD93sdYEKNi3D4s\\\\\\\\\\\\\\\/uB8pf5GuFZs7xOK3HuFGkpu\\\\\\\\\\\\\\\/j30NKh0f4bDGRHXOd\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/XAS9+dyywGl5oyqxGfms4PRjxMg14Vil7owjdVJq4j7VBsqrM5pUSYkmRUDZx8wE0Y6E7vzGFJq6DZbCGRMocQYmDPPwOxXQFakEq413hqARn4bk9FRj82hbX8u+n3C58PVEIYieBBJi1widfrerRxSQMTeyKsWKedslHA3KG0yPTKIm82q0rNT+AyGI5fyqWf92ZXZqQgTE0uZmcz\\\\\\\\\\\\\\\/afvc86bKwMnkmBE2gMp\\\\\\\\\\\\\\\/Rzdkv1\\\\\\\\\\\\\\\/xg4YAGGd0atvSk1aZy3I4tTEC4E59Lpc5kaLl+Wh56UYaA2k9vJvQ6tk4GTD2pNnWc+7SZBgOX+v\\\\\\\\\\\\\\\/sSgxvsD8hcUhTMxHllOQ5jjge2xkn5UxjaNefGFz8m6yQEECA44HFn97ZWClp+XX07DlrjMpz3yc3evo6lwzGNg7N9WNG\\\\\\\\\\\\\\\/WMTIe\\\\\\\\\\\\\\\/pNi3\\\\\\\\\\\\\\\/fiu+jgPgbDX+ZZDyiQt\\\\\\\\\\\\\\\/Udvi8+jt49jkFGeLmMZTNowBn\\\\\\\\\\\\\\\/ADexVv7CVFeOFlBphPiBfyMmJvTSc+lvG51FP7\\\\\\\\\\\\\\\/K1hDaWZ5xTdxgmg5OplzIRAF+lv9Viq2FHhnDAyfmHG52AiCI6kGDythBnTDqyOf909UnYoNG0U6IRGi03pYUjSkCZWFH+HggPDfbefOKMYxs34nU+4\\\\\\\\\\\\\\\/33w5qyzVJnFvusQXU5jNNM2LHtW36zOVcnPeQ3Kw4crWXZRpoKqaiiMp8yGZRxn7Tu0RPjlkIF4ra7PBttpOjtDLU6rdyMXB\\\\\\\\\\\\\\\/WiaGJsKXHWfCGlIpACXa5VNpyKNzVZ5Qa2Ge0TsYj1TKADWfZd3GOLDAuV+5zQhRJEso4rE8Apz62DtDPXGl9s\\\\\\\\\\\\\\\/zHbQFVcCO6xd2I\\\\\\\\\\\\\\\/fjVeyqcwXeEXQ9miDYCUaYhwc9O10igNXO16OgisvJua16ncFCs6\\\\\\\\\\\\\\\/zs\\\\\\\\\\\\\\\/89UufxSLWHZpv2\\\\\\\\\\\\\\\/FWvnWv79OfwNZbNTbxXtMZcphg\\\\\\\\\\\\\\\/fGgyxVgkx6Pu+g6dyPc9GJMYwPysCRk1zbhOYEHkHp\\\\\\\\\\\\\\\/Rz2ptRe7G14Q4WsKh\\\\\\\\\\\\\\\/D7gfD1f9GxF2jmDy72O8OSPRNWoUqDSLveVb2o86GJTNsUJAI78uMo2R0YFM1tPjZEUoMNq47oS1XXKATpekrlYnnX2\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/HsuB7eTnuDdLWkOcQv74lUw1utm7oCF6qV1mm2OqKfAPDDWXFnQyMSY25MO6fBLNxxn6N57vS1Tzm71pYcg9pUCzuDQwjfMX9D5+vMFmBSikkhyHbmV9dBmJ3VkhQ3KKxb4hqr+WNNEHUnM4w2CaXu6K9NeTvhF2kykRQMaJ3OYk77SMNTvyT6erncZjwuBpOM5EV9ffj47R\\\\\\\\\\\\\\\/FUBBTjMpIWZlkShllqwohEA2VEJ4GExz2aUkmX7\\\\\\\\\\\\\\\/kYd1dTlSVnahkfRv5ItlE\\\\\\\\\\\\\\\/soLXQrz7JP5mB4fGmdOhAE6N+e9SJs13BzNK+ReaFy+oryUZfZ5JLg+Eb9wuTWKNh7xFFhuR6\\\\\\\\\\\\\\\/yN8M+5fHK1VgKzUdwg07AV0iE4j7Y6UlMcx1WTadfXQMIjZvML3g\\\\\\\\\\\\\\\/u6B887Y6c6u\\\\\\\\\\\\\\\/DVo1av5BMw2ub1rsUo1kYVvCTfngOYIKfvFkHL3zbIukJVVlEBT5D4iF4j9wGyvfg5N78u8dSjVyiT0T4lXqUZ\\\\\\\\\\\\\\\/QWrMQACHQ\\\\\\\\\\\\\\\/n5fzsrHomN4GfQr6IDdFaUpHuzj4WD03Q1QLKmDFUzNX4BUImJZVxKmcRoWkoutsjxJC7ImRIsxuQtUI3gpDGmtDUWwioLFoEL8jzgGMpmzNMUMuU4h9X5xR9b+NbNDYFQpFx9j\\\\\\\\\\\\\\\/Qkxqi9U4s8aqGayYRC7acz2lMgZTZBUkUzg97GY90yqciTRWdvoHJm4Z3yPXyX92xRZH0u19+UP58dp5iMn7At1SDqXsIrAtx9nKk1ELsp8lLjfpfJDgZRJ\\\\\\\\\\\\\\\/6LQvv9b6ZrxebSNNSirDN2bSgHdepKxEQVp9Cn3LRKmqFMYkGmLacjl3\\\\\\\\\\\\\\\/0vv+aBWDnXIFF9Set5iDyaz\\\\\\\\\\\\\\\/CtXTahUAXA7x9o0L4x00C02f82aI530x1UFKk\\\\\\\\\\\\\\\/Ccj8c6ijfcdiOgzHY50juLmkBB00RkA1M9AfjKBBmSQCT77Xo9RORSnne30o53pFNd8TLAXyuiyNHee3d9yvfq1RcUsNKBMeE4GQH1LXOw9HR9b+YJXBM\\\\\\\\\\\\\\\/H30=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022tTveq9XEnExd43VsVOzVEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226bf2b4b868115a834af68bcd7c1c34d0e57429b92683662b50f4d84e0bf81747\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P92.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/P92.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_3\\\/P92\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S3-P92\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S3-P92\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S3-P92\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}