{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002290xC7zMAKvEqJgS9dpj6mPtqS45WcOlXDCTRRDuM1eT0hr4Vlu5NVsRAMRbm9OcoO3Hjsxp9ZXTnYa7Q35DYfdfSAwgslsmUAuaAyxnlTbRUmbeIbT\\\\\\\\\\\\\\\/Hr\\\\\\\\\\\\\\\/4OYBcXBO370y1sIrleWlsmB4vruagFzXVBQSfXVkLSsoZ7Y636twZm4VpQ+04a6EeKr82M5OKnM2K+Npao1Trfb5JUN28QUHU16rASJx\\\\\\\\\\\\\\\/zVFQ2GCX7LGBegSspM1UpbZNe6NIRxO1zoDTIO3xC5j\\\\\\\\\\\\\\\/pBSB\\\\\\\\\\\\\\\/WmsvN1YqObGaI8yXQT6iHbHJXwG2SeHQl0NZojsICZ2Z17aWnsh2dr1UJAeDX2dbyW6YgrHOhQyyM6TSNZILLaS4\\\\\\\\\\\\\\\/npf06sus1l37jIiEWKjx4cnVEApPbnL\\\\\\\\\\\\\\\/20M+tWH56RLKgD2q1epFARxRbSVqmftjEBFTxeGdP7ehvS+\\\\\\\\\\\\\\\/HW9p8lht9FEn2A\\\\\\\\\\\\\\\/dMg8SwSK\\\\\\\\\\\\\\\/AZqhgrKXXitMSdql3gIpTThOQqMzlOttO01kndklBchtjSaNUWW12IT09MO34pqJ3In8JrP7+KnqQrQlE9wxWVXkP+N3riwz6CIYPlnO44LM8lO2q6BaHM3AUHC+jj8mkDA\\\\\\\\\\\\\\\/ZTE9nr5npRxf97vBkVzQNnwSRFgHcjiJBe3TP2H0tZmbT065VmXKu+SPPg9wLQMd3BuI7X6SanfD2ZVtSRS+vKGCQxVRlmV+NXbrWIu9lw0dmOaBfRqKWIixjWULztk+RE5gbkWpz2HCDrc6A4te6ZQhJMhhDR\\\\\\\\\\\\\\\/8eMAszzxialPT31NXqsZf1qdHW+6OEkl1JcVYwEdFcmF\\\\\\\\\\\\\\\/H+oYbmgzuUlTfrFd5Ng\\\\\\\\\\\\\\\/d33PbUn4hmN\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Wm62Ng2oZRid\\\\\\\\\\\\\\\/gWNmJZkkJ8m+IBgYrFkJc6gaLDiWE3xbR0xXBn9GKGxRxYAy7MiSbMzZ1o+THsSwbbrT39ASSpiMwSm30\\\\\\\\\\\\\\\/C1ITU\\\\\\\\\\\\\\\/+hBNbF1LRIOW0\\\\\\\\\\\\\\\/dBnUkC45rQxYPUj6T6\\\\\\\\\\\\\\\/NS7FCooUQZmdlpSlpY3bIBN2TCu3aYuH9\\\\\\\\\\\\\\\/v4wzpfBHk+80kVVHrx\\\\\\\\\\\\\\\/ZE\\\\\\\\\\\\\\\/fI4A7daJ5OzTqOjs\\\\\\\\\\\\\\\/FnU96yIsgrGoBVBKQCZ\\\\\\\\\\\\\\\/0kp4FoQ+6ewvxdmfYQrASkif2qSmLgw3BhTgNZazzHKvQA3ho4STCBMsxAb8ARoR1cnPSXrzoUue+lJo0Il4H54S2VnT0vuxkpWXCSuEqVrrAHvga5sf27AOrBaO7warCIpHUCPY\\\\\\\\\\\\\\\/h\\\\\\\\\\\\\\\/2x2ordfPCdh\\\\\\\\\\\\\\\/Sf3TB+0uYt1hSRGs2PE+iOtb+x\\\\\\\\\\\\\\\/K+pJ7fcBrJZ+SbT0y2GrNTVMuxQmQsr92YPPIIglxfZET5AG7uAxyZuBqVVXDhvRn5oYlO\\\\\\\\\\\\\\\/EmxnM6wtlg7XDzK80sjfoze5sFm11l\\\\\\\\\\\\\\\/S6xrHpveTMuSBsyW\\\\\\\\\\\\\\\/OGc3oRTuTScWm4\\\\\\\\\\\\\\\/Wh6PlEYXgE5TjGYTN3gK1AVFXKEp74rxTf6J44Dy219uER2tMEeaIWMC58I+3r0hwSrjHZEXrfl1JJyKo7WUQ6\\\\\\\\\\\\\\\/AhSkKwspyfFN49ZZFHPYMD8OON25D9zr598ZYR5odb5B+N7GTMre+3zsichGXW6mPbOaMpVrdGfJ3X6NQSUdXxx6sjpvkkVzECjn6\\\\\\\\\\\\\\\/l1vljDUevV3HChhjRGvr6cswWgXLEqbkNwTcmRZARc\\\\\\\\\\\\\\\/wVGzCsbGuSuF5fZqy3qi1KFldYPb516zW9xRQLemaIJ5yVKxt+L8nJ3kGUvhVFUkyWpJqk+biAPNm5I89G52aABFRJ\\\\\\\\\\\\\\\/igYpJXK9Vh9cCeD2GbLHkAvLALdKHTOnOqp9p1N3QoLvIusIYueKS+4P1NLImPcRXExxaMfP4eeYSnPj2GFMem\\\\\\\\\\\\\\\/uJcOJStOasp1krusbbKvu0ERy2tHgBLESD799Ubm+Xyn5+n5W8pNb4fSxUu9YqMpPjR6oH9dAA1P4tWgzbO1hx6uUyKYCiT18EjDHGqsmSOl6IyvfvlzcZQURmHSzCceqVsORKThy\\\\\\\\\\\\\\\/atBgp\\\\\\\\\\\\\\\/zBpxVCZV9h2P+uZQAuNlcWd\\\\\\\\\\\\\\\/qY5Ng4fIQyTrvmHdBUejrGyn62N+UjLWiaiZkK9bL5wRCsTZPUZXr\\\\\\\\\\\\\\\/MsjWYO2M5faHXY01ZUc+2gAW\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/xek8JQnb2zQXoEWL0NgJbA\\\\\\\\\\\\\\\/0TvxYeD\\\\\\\\\\\\\\\/mfcQEE+dh2bD0SfyTsawWf3EKWC9KLSFu5d\\\\\\\\\\\\\\\/8J8hpP\\\\\\\\\\\\\\\/TKfdHKlwgDofppNwuST11Ibs6q2WcgC7eU6drOYsvWEq0qL2nfQt\\\\\\\\\\\\\\\/jsgDToSkR9F0IerDBpgPTuoxHM++Nfozq\\\\\\\\\\\\\\\/xJedbfuEVXeof6gP6VUoi8QLTjwRv9TVna\\\\\\\\\\\\\\\/3M9Fm3SFE5viLMcDxcpPK1SxcUBijgijLrIYUxWWQhkOlEQxTi8fses0XOtSEnBGSN53jpsoe0KNKGVtH9ErGCyuiN9+MZgoJmiV8znT3tpJCKm6xyYZNiRNsYCSFXCxb0vAEBgIC6c5FNutDCNssiS6Rlw4XDUqzH0WMEccwDVaARX5XZMu5Xdd\\\\\\\\\\\\\\\/MaqOnAaPvOHI+qXFkprJNFhh+pVygwzSfAwuq5hF0+GCwXq5X13t24vprWhIUQ84D0qN+6TDxrlyRtKtiYLlACqVtpCohwr3LFe4fbpCOOUu6btFk7TvlrIakRGhNhgQkkbS51UvtCVsSlJjshZywTSAEn9X9HUegqdSqUxHV0xkzk35fh07dSgfalv9Pc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022nPkmQoyjQXlyVZTt\\\\\\\\\\\\\\\/QMpeg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b388dd4537be9c7adff27223505b66bec3fa720bffdbeae14019dd56b10aed1a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/4\\\/e006718.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/4\\\/e006718.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006718\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006718\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006718\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}