{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022W61GElwkVCM7gBiLH8JtM0xgdEcN674kZYPzMYap1dTJJObdvrPM98jJotil1eMOCd1H2d317Cg2JoUAz3ZbZgekUFFNem0LVoBIfnE292Wxx1brxYsIgXg831HCi\\\\\\\\\\\\\\\/dMtqY0TQDBdYKuiuJ6XBzdH3qaL9YhsJiP84RIhQ1Ptw1w3p+I0M\\\\\\\\\\\\\\\/CStU9LXQZS6mz4lukX9YxfHt8nPNkdEDQ0Xcs1tON7LQmUpdFqYHtd\\\\\\\\\\\\\\\/sh5uSCs0bEfjKu3uE6WjF\\\\\\\\\\\\\\\/mCp\\\\\\\\\\\\\\\/Q9V9GTEUQIr8hSMsaB2KYeEEs0gPpHn\\\\\\\\\\\\\\\/sJbVk6LOKinog\\\\\\\\\\\\\\\/dYxBx8DjZvPuek12PwGrJuzD2AkRwS3ohBK5s\\\\\\\\\\\\\\\/2qOyXatvEwjUxdpXDAjTf\\\\\\\\\\\\\\\/21LinoayoVbRO\\\\\\\\\\\\\\\/z8+85Pg52vuWndIOJLyxRbiK8yAtGwkL3dKMkvmEhp9Mm6Qiq+\\\\\\\\\\\\\\\/NnfUtvptU9CXFqzwutE2lS0tXQRuk2SDIXoZRLsZS4\\\\\\\\\\\\\\\/ahE\\\\\\\\\\\\\\\/hmuAw+AHRirMl8Cy9oHUAigIieQ886f7lVhkHTrg8TwJ0J2pG1x2LBNu7PJhTq\\\\\\\\\\\\\\\/v4OF\\\\\\\\\\\\\\\/yHkZF3FOPg2Zxp3KsW\\\\\\\\\\\\\\\/qMko+geKOpMbjspZO0JjSnDtNRdQGU15YCjv36lR1DeYABd0\\\\\\\\\\\\\\\/vEWF1T3S1GR7NgiEZ7byO9w3wQ75GLIBbhbp1t5ZDL6i8lW4rs0XVMciORbjEjsX0l+6MHkGVPB1u6gaiu21\\\\\\\\\\\\\\\/btfaURz8nX5g9m3faeo36yMGI0j3FTryQDisSA5km5oXrLTqVPVuGsItl6UDoAKQnKyUN0d0hVRBRW8ZtFZh4KmNCKGMO37e5Aq7m4eWdKO7DUAr2BtN3zMVcij5Z4XYc6kICJnf8bxaZSFHCEmrBer0wAWXoZj+GdX+kPDKm325NQtWL43wntPMqVaZ1UqEbfBdFaDGqljQYyDq4wezkkxvZ2lzpO3GNhH7E80aKTCYy0RzKFzB4dABAr9d3Sc5Z6n1UHIRD2wV2PVQZKt1EO5\\\\\\\\\\\\\\\/eBAA4UqumemJlLpbWdlZ1vytMvC\\\\\\\\\\\\\\\/SLYtD85EfW3q7cIwWobbo\\\\\\\\\\\\\\\/83SYRoLRrIV9AJXom4kqeo0wX2LOlqsBjE4nbT89BAZEvuql4jcoduqm6k+1gwraCx2K50fbkp62w7NNqHKdL3qFsl4uaHytFGkOCEXylwReI3j5FlC903xQXiSoSmda8fubEwoBarOMK0gGTnoQU0ECERYjN7vg\\\\\\\\\\\\\\\/eL2oF4iFOJSBohcC66y9IO91gObpSwEKko5RuFPPFZuswaCoejq8Ra1BC6X04jNzVeNcTLvLhcnsUdby8peUWgaHMzJ5PqoywGc8M4M2H+TmQvdI0hT2scDcYv05jMzhq8oYMPSCF301qhQ8qGd+pyij9eqG+O1RDHtbtxoMT2PEMGx6AGEXSuU2ZAAZBzB35JGMpB7sbMHg6Qmrhq5g+HNZWPLYRZO9o6X24BwUTQR3Jj89zTs0i5lUZ4U8FKIqL0Z\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/5ENn8CSEcrgDgo4uTFdpxkSjZLD01p\\\\\\\\\\\\\\\/JpbFjTM5lKBjkQbAq0fy9VqpgAx4QPpiQQ201q5EFVmmkGJ0eTZE2PRTDXM\\\\\\\\\\\\\\\/Cwrj2FLFSbX6p3FWKPVfpDeLswn6b9Z47fOTQnwXXi\\\\\\\\\\\\\\\/jWT8uQxhhGlnEakl3EU2opNgdl21Rr+M68tbsyzCaGbAtrYFvJdw3YgRo4A5qlXISs6w9Imkx2Clai\\\\\\\\\\\\\\\/IkDGimDkLY5G2S8qGsge\\\\\\\\\\\\\\\/Oa90+6RSWYgHWUF5FDytdhVw6RyAHJqqBeKVCUmxiY\\\\\\\\\\\\\\\/F6mJE91C51eG5HZZ7bItwdqyjmbBx27ltZGoGyt1TanR8y5dLU7HnE2R9avsLJsVooSBRx6oKadYeqxAKmk\\\\\\\\\\\\\\\/H0WuipxLQkJqNU0e5VZ4+Njgq6oHrIj3HcXrNn2KEJtquUwlJnE3GqWaUcoVyP9gdSOs4hR+OLaLCy+cMUsCRwKULbMdBseuEZIs7qDVgYZWKYAGb7Dzn\\\\\\\\\\\\\\\/jIafITTOQDGhCAu3T4VRdzLha5f4AdSEqagxyuPjMcrSR+71GeavOaQYfwB4rWAK5uemaJZGBp8V6D+lhKmDqGKvkvnqapWpI5YLMnvPJkj61oLqosky8OKWJ5AZaUB7HZG\\\\\\\\\\\\\\\/wKGKQ8umK5O9G2EueYOHkujMIWTU9u8M4rW\\\\\\\\\\\\\\\/br63dKgu4SDRIWEHdO2bWdkVcDT\\\\\\\\\\\\\\\/B4YWDDdyEplU97qsPTUPzEcjCuJw1KsEJPvtXfJiPlBjStwn9s4FFuVdRK3exTzqQnJBj6NpUUJZJAUefBBtO2Rl3MdgYnf+28XnobzWCo8KdWCrIlJ\\\\\\\\\\\\\\\/VQufg2CocgwS+ZSS7gCAacb+UVBY66oKvqu\\\\\\\\\\\\\\\/RzF+LPTeYctjOUqInbEkV3VW0tKAX+uMLLjQzyTU0C95R6DnRyC+9nbEHh8sePzqvS92UkGWDpc+d0THFoWCuICx359PtRcL\\\\\\\\\\\\\\\/zJJP5MRMe7JxU1AW7eITqrcyKYOC3lRag9fGpGPggtE3QC\\\\\\\\\\\\\\\/R+9CDF\\\\\\\\\\\\\\\/b6j5+w2CVzphSmbf5O7IGg\\\\\\\\\\\\\\\/h1gVsrZRAuMKgFrKcBFLgmHmyPO\\\\\\\\\\\\\\\/Et3NdWY5\\\\\\\\\\\\\\\/9e0otgvKku1NSDunVEAPiPmyEUI6f\\\\\\\\\\\\\\\/L4X4HEPQFtlEs6g548f5R5xzeniLnn2v4agO5m0H90ACWxoVGMVlUtSJeSYDXCyaRTBGE066hj\\\\\\\\\\\\\\\/PXpylIOc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022LdtQR4TqMNzVhTjG5v912A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220f51c33c777231e23183fc4583653996e353ef897ec7468e259289299d333f42\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/4\\\/e002838corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/4\\\/e002838corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/4\\\/e002838corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002838corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002838corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002838corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}