{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LPwsJw5ifYHbYR5DTAZk1mOvoh9paLQkfrG\\\\\\\\\\\\\\\/aFgcLHrqgQg0KMvZ+m4jmHjbibCoe87yh6Q61rs23EecBOrRkTGd\\\\\\\\\\\\\\\/H3E0Ds7pZs9Nnczh3ckrlXbpAUUourc2e3LpKgFpcEf068RkmF3g01+UigMtJ8raC683gMhXew3kxK8E97i3bokVcH8Y2vbAee9W0P7ZPrg4\\\\\\\\\\\\\\\/WkzC3l\\\\\\\\\\\\\\\/duxmINgsde6ofK+yKljdmkvwIfKgSBrcQjZW07B9caN38wZLyN\\\\\\\\\\\\\\\/fkk75YuHCPC71IsiDNqEW5KExlR49qP5kvIQaAXbsiyLFlcDvhTP3W4c\\\\\\\\\\\\\\\/kiUcw7i07Yo9\\\\\\\\\\\\\\\/cdUVDz69ezIfOWK++rgOEBv20E55WdnAZvUYZmb1PXeJHeDwyeq2V5CEYVadG+uRChCEHBcPu1r9Q8toAXh4b6PeWa6YeCEK\\\\\\\\\\\\\\\/us1QV+ylYJ7Cd7rFOGaHq7Dy1zXayRY4N7Pa4RgKwqIurc9j2oQsvKezViJw\\\\\\\\\\\\\\\/i7QM\\\\\\\\\\\\\\\/PIxcPYrtzk8hOLKA2VcI9Z2j57e6545oLdhRWUjUtiC6snUsiLmwrRDgsgkPIMbu46m+mKx3B92gJfhge+NzI1wLh7lsO0sQDcOemF4kvs18+7k7LGHNy\\\\\\\\\\\\\\\/K5w0E7X4xyFleIFH+NiqN5Jjfu24AncuJxW8iVSNVacwRlLcu2jBIgU8lr\\\\\\\\\\\\\\\/umPCxdatW9\\\\\\\\\\\\\\\/vNn6uW6zKK4Fy75TnAitBK9rR62fbnqRWcekK+lN3KKcrkhGDg+LOGISz3QiFe0tm33dUJGWUQDp+2Ag72Gk+8Vu2uONlyStOwbXG4KxSxPt1ytw2dWDoIVeaKnsQeVhgNDFyT13NwWmmHEHj8OhwbRe3rlu\\\\\\\\\\\\\\\/vd5s+6kaHe2IbFoYjmAYalN3KZoWXHzMHAnPLQgMzGjtA5m57B71AZXVipy55xvCrE7EL9pqmAlDFv5oHvL7A06YY2Ar0vzg6JFXzf0qtBcXI00UwCkx68DC4jolUueO\\\\\\\\\\\\\\\/NOH98L5rDfuTprLYrG\\\\\\\\\\\\\\\/gCj+muCymMGNLcKc7+p+QPi1O1KEwkxB9NIthisO3JwbLk87sOYx8w+y9Vvj6GtfaLiKH8L3u4m33m8ZVW7r0ahmiOmfLkeifQNsec\\\\\\\\\\\\\\\/3HMBO78n273eB8FA\\\\\\\\\\\\\\\/caQ1r8\\\\\\\\\\\\\\\/zqGycf5GPrKSiIEcSepacLzVbQY\\\\\\\\\\\\\\\/e1JbtEpkfRx27P4JHBp7GANL+s4S+iXKmW9pSmIzI56Jddod+h99bQIq5SLhqhnsv9V3y5EEcfkA4pZzNyMk+y0QAVquOnJSMJI1mqpJV9lDYq8OXULxhX95xLVhG7sM5TlOg2Yi3Qki1BxmcfkQXp8CeAZ\\\\\\\\\\\\\\\/oEzsfKup3L17VHUWPuD29oTQ7nR+nueaRaYmjoYNxrszxh+R15wONYXUkxvu30nU6wRCEXvUsB7wtQ+VBsxDK1C9s50me+l0s\\\\\\\\\\\\\\\/PxQZf22FiF+nbR3EgJBwTZsr0VRv5FYq7vXrpIvqgRA89AscCBNsg4UUTqgH0XSYIDCgITCpIDCEGsLe07YvWTQKv4h14YokGq7ASn+h7WWH+8UHer8daLuc7bahiM5loiyaJ0e+xcw6l6CeqxrXJLpwu7IDpsBmPwXi0aXyaBE92hFb57tLIA1Qtp0P6UHIh5RlDvG1HR0uxUmdCq9kueEgZCuDBYG3jci1ekxlzQXdAlotQoENgW5991d1wETYr\\\\\\\\\\\\\\\/b5pkWGcJGhUC7Vjb6YklEWjkb5uW0TSwgvnb02S35V6Uxfv6DfLq21Mp0B\\\\\\\\\\\\\\\/jcj4jtAFv20Bll+nbh8ig2h7psDon3mfc6Qt9M9OJ0EyxRBA0Qrd4wwtSqs1SjK7uQNVRunS1Z6vV9Qn+2RfvsQV90tY2Qe5l\\\\\\\\\\\\\\\/CJhem3ITX492\\\\\\\\\\\\\\\/Gwh6S5U0s5S8UbLJa2Ym4rKOMFpMwHi7wsNF9Xvwu\\\\\\\\\\\\\\\/GSeSukcsqKAnDYwokBfCnzt+CpjQ7AIvq076ysYuqgZ6HtXTJVUHcOsQR4BcWN\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/pYnmPhehn+wJ6BQEwXn03vEFgX2FYHdPNWYc31c5BbI\\\\\\\\\\\\\\\/HYwXVMNhW+nirSTZfSOMYTE6ztD+1fj2ffETJFnMotxOQkg3p395CPP6+wuz2B8eDnWP1IbOUljzdAMFYkEbvWt276Oi5ARLQV8K+zBJyOkAnbPg7MNhpGoodc08njP8IMbBWgg8D9Ckx08D+Hsjy07DcOf3t544xdNY4fRLIbbidIE3DTr6pHVW+LO70lgQf9pwjMYlB1mZAfOg+\\\\\\\\\\\\\\\/gU4xv24ezSQIWqGR1trvrIqrEcdV7Tvq73GeEETrmtJ56tOKY+04qTmT9HFoUKhVTQ8RIS1PxlJsNvfmZAf9eUuP34t9Pqs46diJZwIFH52jlAT5mZWOZnFruaEJMxaeXtzzEVHTDpdXleO47fMpPwFS2abSuzaVjI1XN3D9Z2s5BeCO8SWxuCpQxtndwZRLItL67Z2MxLkRUtSVsov7NGB8KLLk9r4uzOhVds5E6cJGwdrg3o8Uv7bmNsRk0FkmS9lmr\\\\\\\\\\\\\\\/QL7s14U6pRIdoO0NYlieOhnphMiueAJtp8HDFlMtj+olzpiDCFueH1BAslgoNrL\\\\\\\\\\\\\\\/emqBCBwCmgafX0bFi1W+7C1MsYpLAW8Cj32uNBO0nm0sfGk443gu5rPTHyn0yU0EliJw2en1Qy+emWaz5JupI+awEvswoTjauk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dgrsAcFzfYY4+JbouqrLdA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f3fed369a7a60e0d080f0bfcc9764a2b9a865c5e3356ed15a09e04d35639b5e5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/4\\\/e005539.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/4\\\/e005539.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005539\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005539\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005539\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}