{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022owNZbYDz24nDBZXG+guL3aHqQZKTI4ctWA9EXpK0bWeHlY9tQcn40VW1jrx\\\\\\\\\\\\\\\/aTLvUPXHsEqGeHGacn3NEfw\\\\\\\\\\\\\\\/mi0yIItpQb\\\\\\\\\\\\\\\/OXLaXPPcegaVNaaHn08iNnaa2wXYZFsmPjHmfE8zGT\\\\\\\\\\\\\\\/QpdXQaCnk\\\\\\\\\\\\\\\/iseyv+Ue4pS3xclb1g\\\\\\\\\\\\\\\/s95QMQvttIoSSxmNy7Q5AXKg+IUvAM\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/KapP25DvbpBB8Oerr8B5zC7jzsYZHNE5OhtVguGgVutHftey1irybmyLjE3eOC7QC3gm9CRuxJbRBLnlAQ+JRx6WpC9JjEVyX09rtKP\\\\\\\\\\\\\\\/lGf5NSxX6JhBxwVmlge8S3jzDY1921iDE30JMp8I3IYujX\\\\\\\\\\\\\\\/0pcQXyZ1JB2d9wrLyYjBSHiJTNuyrvUcbVBR4Yg5PndZh0AI0NB5UN24wKTqlTkPSEc1RueHzm10Mc0leOOl98EzACYv9Z4Vgxaj4AlErcEWWZFPgfyvJlKJX7qDyAkylYgcdLzy2JEcxRPGRhw2\\\\\\\\\\\\\\\/ZEM8clfHr20BorU6Uw\\\\\\\\\\\\\\\/bewn7liEsCGWKUABbJF1R3uJMVKX6fxfyKPlo0votRiIfwUhowzObN8wVLZC7f8AeK9f1vT5mAaxi0ce\\\\\\\\\\\\\\\/818t2iGSS3Mbcbd2o2WKMgRxyvnGgZHp2FbiZrD+\\\\\\\\\\\\\\\/FASJZtwc\\\\\\\\\\\\\\\/3HDc0UwinU6IMoHsmu05jJec8H9S\\\\\\\\\\\\\\\/Mef77M5Y5\\\\\\\\\\\\\\\/vIp8GX8GZG82ePZtmjZ5Xj7OVOH\\\\\\\\\\\\\\\/ZfqLi+aGHtLDg\\\\\\\\\\\\\\\/uQUBkk7twnjfkOmnL4vlITCwE+9TevypL4L\\\\\\\\\\\\\\\/coAC+9fR3bGfX+LpHZFPuEo6W+fASZ91nrBDESNjcVWXULGd1FkwKUubW1n1VL+qMhilD2eknawzGUFWT5hyOFQETMwIrC+G3YtRWAR2ytp+CIaBz\\\\\\\\\\\\\\\/eXJAKBtCvXIeobaR4iSgKbNrYSEjiRf\\\\\\\\\\\\\\\/hvTTSU79EfXjkT72Mx6Nmsr+6mvGa3AMyoMgF4AIoMXM2z6O8830ksTkD97dTJz\\\\\\\\\\\\\\\/tsmPHLuWVJ\\\\\\\\\\\\\\\/zOsX6ymc+Hn95hQv0rCd94ug2iDn9+7C0Zv66bwcuJDEPhP1o1N8vp3PKe2Q2ip5GBc5s2RdS71k1yd++zzb6VLtHulvnt6H+ijFY\\\\\\\\\\\\\\\/wsq6RZ82VITcXfOyOxM8Ad0qsAwBAYJ51+FcZrJqurfucKg1IndOMpzT7u1JjXi7eQ73mxyn\\\\\\\\\\\\\\\/Z5kj23e3z1hLavlzR2k2UM4UlqbHINfn+DP0hIyw\\\\\\\\\\\\\\\/hbPKbHALyCw+c43rj4bmbkwo9\\\\\\\\\\\\\\\/D8Hpf+DLbHoxR9fV2tOMyuQEvvMBHAa\\\\\\\\\\\\\\\/sF0XaaX+8yFPKSzVqVvJe53PNI0fvQANevp83eohnEEmps+e2Siur06MyuMgFm\\\\\\\\\\\\\\\/ggJnIW3AI\\\\\\\\\\\\\\\/ZPJVPposZad1GThdvRx75A3C2VUbGgsK\\\\\\\\\\\\\\\/LlHWlHgQwUEFrhTKD4Kskcax\\\\\\\\\\\\\\\/ErxLMG1g42HSVvLjmVvjTRDtBurrifUqFPSa8ilA0dnECQXWDDGOoTRAXrBjnXGBa4Rpva0i0O7PeLxGrrFzP3yDMrsdc1UQeiedFaTSXogZOnpFadzH2Ra+iasGB9K6hTUTlLXa\\\\\\\\\\\\\\\/QgEbU2Go2oTaljlMo\\\\\\\\\\\\\\\/u2BsFr0W8doAVnQrkyMdGo2ZILeO6X8zpHd3MUpaH\\\\\\\\\\\\\\\/TaNsh8SlAknI+Rc2pVAmUalAB86EBaJvqtdUELAlXPcYzw1q\\\\\\\\\\\\\\\/tj6yuNih\\\\\\\\\\\\\\\/FC+84Vp13c8Car1StxStIWC6vA0v\\\\\\\\\\\\\\\/P3PkKJ9tycz9mbAaUPefs2yXlPd79gDSqQtov4YqnTcAUbmQT7rtzTaXK5icxsfxnsDrgQ9h0DighbRbZwvsWYT18e1dnKfhYxYAlGE+eW9MUONpqXIFHs34HZMBISOtdqjNtuG7SPUYG6GfJqW96oWMGwp8j4jlSZCgfvPl+mZwiPY7GZsQOfYLV8yOS75WWlZCqYg2soY1cipHhUbZHzky7+79tlx8Hv0yaSeLnC5ZNjwTJTOkJ8MACjlHixsTg0VYkUCOinhmGNGo3N4J5lQFq1lCW3gFn7KBTHkJwyANQxoirtXor\\\\\\\\\\\\\\\/7vcsJwEGdzwBm3xlxxmHJifsXK5VJhFqIHuQg+LFMzAK4pMpjmFE9WoxgWsMzUq4ufdbmTnlvjqBnLHspzbjfLYMsMuDzGnf5Vvw1Ntv7ORtE5Wc\\\\\\\\\\\\\\\/I4OHGYClqXd2TDF7UeohG+lwk8n3oirP4rc5Cn76us8xhzs9QJmfTpeaMzA0132Ih+5FlDPhEhpbYsT\\\\\\\\\\\\\\\/iRMXC1cIs57u8LOEqX8m8eB2OPuQPHaxACk8eMRUbWQaGgfa1vcRfklCCt+BW2lSvHK3jeEiPVpZCQP96WGCVVw3INcKAFHmGp4zcb8HVxaWsJUVHUQMyo9G9UXpaEaayyIPSl1ev4J2ojJWeS+T5f3+Z4HmCqGK0pFlTmeSHx8zaGGzE0pu+uurAANya1yjEPDK0TO8nrsrox6fjhkzfvRXUVKbm0jQSWUASiVPr3o\\\\\\\\\\\\\\\/tvYNNAbBczyODM0vZHnQujmjTtcGXb8+IiJZ\\\\\\\\\\\\\\\/EfRLccDLGhNVEF\\\\\\\\\\\\\\\/QqtL3Yl\\\\\\\\\\\\\\\/5ecAWRBvIEFymcD0SFAiS\\\\\\\\\\\\\\\/MR+gcVH+uXtoLW92UeXhxgG6CyE2dOCLWCoYZxF2vtE90ayvMzrMRk3E3nSQCztAdRV3QEFqo7dqWTeD0O1F+jvJNLLbWx2bmTCYSeGihk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UXqLVgzZ4JUE0C0Ij8Z8Xg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224b7bee6675c4b21ac61149c73058e674b066086aa19e5f224aa0cbb5a6186189\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/4\\\/e005839.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/4\\\/e005839.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005839\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005839\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005839\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}