{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022H2V8owOa+p8l8WAZDivcrEUSq1HKtQ85fUA9dReVHMpbQDriehCTfZtnbkiTfF2MEAcYBAj0YD2Pwvep8DpNN1xMU46wenJy4fD7ckHm45H20qcpVshQMA0xXACuemVL1WR188CXWOY3lIMvSNVpipSZ1J+fu8eNixodwelZ1UN99cd3jtfSYDWfcWlvPWLJ0lxysywsz+ENGFIk+xqZtdci4bXcCeA5lAKm1IGPq7qzkYowbHdIIaMgmth6BQuHZ+Lk7E2D912h1CdDvimyxYjPw8v7N2S+2fjR7kLtnRzv7s2\\\\\\\\\\\\\\\/BtIxZXJYUWJzUO6r4RFRtyTsRhYecaLerzyIi\\\\\\\\\\\\\\\/xQz+KzdbE7v9nBmHdIav0IMdFY0Ei6Szwb4l5i0DjFyHy8aVYVo0CwRm2Oq5aUM1WikVDJkAEHxMKXjcI\\\\\\\\\\\\\\\/NOkxIQ4BnA4+2U5Rbf8\\\\\\\\\\\\\\\/tlxhJheYOjo6Ozawzditqu7c9tQg8fTsqeagd3Xiy7pON9VU85Xm8wf2Hn7ri8F4zR\\\\\\\\\\\\\\\/KxENoOnzB+rzkwzCpswmemYQoZ1SKUmJkFj471AED6GUHnpmUtzomkBFN8TMneQEAmQ7HDK271yDY0mCueHumKQHXfQOVcMLF8YaecMvJ3\\\\\\\\\\\\\\\/tfJKlFnrQ37e+tskKaGLmvLCZTyS0KfhThcHJWoS1wK1u0GTHuYwr5zOubaI2XPR6nofHHjOC4Tba2IuRfO0hlvciEVxKy2En7t4oHOMgIA3CrTu0XLLqHB6Y7STzEUl\\\\\\\\\\\\\\\/tYoMm6jGLUwcH80UzS\\\\\\\\\\\\\\\/2PReIy1nhsZWlLn68HFMbhRYhzh7gpLTI8gbUc6wfEAHp5S0rqbZXeH8u60y8dV0kbZzI9gWjO\\\\\\\\\\\\\\\/WXrs+rvLDddoi71tP1g3MZZyXkApkcAOexB7UJs2yXr5tYwZT7CdeNSIZJPWTHStC4TWhSGl6shqJdxgIvytUUYmrIS7w+zuuMD7Q8Y8f9yPJpwFF1t5JRRsGl2KlCzMKakJ9uN3NeoSKP8mrLQ91cg3\\\\\\\\\\\\\\\/sHcXq93q6xELkLOfAfiXmXA9IuuJpJiw3JNb+wtGXm3u058bKXTCvW3b86BElBAASKXAtmTvZsju6A2UnXm0rjuRC\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Z2\\\\\\\\\\\\\\\/ePMYCfcK7K2y4PMVAyGmW2I2676u8lTxuvCHX3JfQhmihDIwPVTiiKNhTbg+yzhfCZVtauNM4AOXKw5ZBP68jUIbg5sJ4\\\\\\\\\\\\\\\/HUfX0+Z2ojOasRk+fBxvtmsR9yKwmxCB7rtUtEhW0PdMY2N8cW999SNhew4X+3VM6fkQTqrwDGtN3mouXrbUlBRfcowcr3fxQXNFBeMoEp1sw0\\\\\\\\\\\\\\\/V8+K3GALrnf\\\\\\\\\\\\\\\/YXJZFHV765VsVYQALcO9MFHRBL+Q0tvBiDM\\\\\\\\\\\\\\\/XyFeBNcEwRhYz4NRU0K\\\\\\\\\\\\\\\/bgvRutFMmnOfAibBg+lVAqXUdOSip8xZ1Y51NFl51IFyizu+IPObDURPux6Q1CwanhQzmunDg\\\\\\\\\\\\\\\/vAHefnGpuS5fjsMHRrcFBwf9BFiVnP\\\\\\\\\\\\\\\/ypTfHie\\\\\\\\\\\\\\\/TKq+JNTRVYkrcT6SkWxjVWq2Jvy6hXHeYUsfI046yrmmhHnlT6TkStN9CClypgSikF5IcoOEN8QaBHnKrsgkvAdnqX5kMKolCFptEBzwnHz4c4Km4jvkj6f5y6HOwRMuvNUKUczTK\\\\\\\\\\\\\\\/tm1TfQZn2z7n4xER3AQ4CFAKaA1lcURciTH6VLE1S9C14FCXqsEMBghXcxxXYpsF51rGPaknZ40O4CM\\\\\\\\\\\\\\\/GiYDT0AnLsf2IoNyZn+NDYKUiHlD1HwRY2vbi3HHF5qKHTxuYnLIcSueiO2U2Py9P0biFdABZ39nQALfZsznlu8ztw1VQgw++2eqxC89KdMFQDYRNZIzsZDXitxdhkRp+notZaHTC99zFrnRvteBaAND+sbbWbfh6TaGHu9dW0Dv0jWzGWQHj7JVw44AmJiBuHXMZpSprAdanzUTio\\\\\\\\\\\\\\\/jFzawokTnFgEepnTE\\\\\\\\\\\\\\\/R5Ql50R9poOj2CW290JApup0D8VkjGMpciUOHBus6PeVCUQdZ9UQalUwHyZ0Hv75yEV4sYjWjnd8fMQA\\\\\\\\\\\\\\\/knZasSDdYnHJQHkw3Bb4iSxc2FcNblBKoWl2ZCCMnwS3Y4b4bYwJTeLsL\\\\\\\\\\\\\\\/Fsu9B9siLHn6jmrCbky1qcDk0ha+U9dDuwODQaDqhSlSV33Sdzh5FS89GbNe15hEh8N+hahhNsDM\\\\\\\\\\\\\\\/Cp83n6Fyd5b3iqsYOlEvJmRYLqcCHOFn7Bu2whY01p5Mbea7FtcL\\\\\\\\\\\\\\\/LN8Tc6oyRqBAA5AEox\\\\\\\\\\\\\\\/o+VQoISKlOWz\\\\\\\\\\\\\\\/wetmLEgecP0wVnlmIM1hfJ28GCQ02DZpQrgIuT3S8ojDQQmRkgY0WHe3BTGic0tLHP8sKAHUc2Wn+1tj+i7Elh\\\\\\\\\\\\\\\/mLNrV8znaUqbthB9SEmd0\\\\\\\\\\\\\\\/GoXDJH4dVa3ucO7Q3w\\\\\\\\\\\\\\\/5HiF3NC1R76Ov62odZlbZbb7cZ24ead4ducfmpzbsMZkHCZ7Th8x4iT5+5zSrTsq4O9kiFT7gsoOXEGaZ0AYKPoM4DkvYlIPniaewydE3Qs6oBOcIFZtc9\\\\\\\\\\\\\\\/QMuMu321L1uRMtIXOIDYeMqU2JUdzAppGHg2kTlQGR6AIOsQiXZUgOVjL6862w4Otty828LSLfvyVqWilue4qS09mPEO6R5DN5MNvmkQuX9u7rj6gHPwryittnrPVlag0nOy+A=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cBPZPXCsExqCMeHEmInC+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022be99d57557e588954674ad9fe68b60d981f63263f5b390cfb9cf674f995ac74c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/4\\\/e005967.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/4\\\/e005967.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005967\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005967\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005967\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}