{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022rDSelGSHHFWqtfK+\\\\\\\\\\\\\\\/Mfh8QGRU1pnkTvkf8ud\\\\\\\\\\\\\\\/Z1K9cClTfEBR+jE3+HJyo5qJF\\\\\\\\\\\\\\\/1AHyVAfsV3z+z9dBJZMluc2fXm5gOzNTpLU+nabx\\\\\\\\\\\\\\\/9v7tgcdawy+tHFjV4AtuJCeC2oELTwzvyNuKnoLF6wookMHBJ7GRK3kF573tF5r98oa95GCvc2Tdh9ZRs07jk0tHzDo2QJeI8eW+uQPvyZma4Ht8rjUJuAntudjgVrrn5rmwyj+aRt83ATMjX2fj9bUAnrUK12+61OdzfzTcpmyx+xmU112oSJUvSQ7HkpeFxabL0cuJ8yGLCw\\\\\\\\\\\\\\\/mc11V50No\\\\\\\\\\\\\\\/xNBV60+Vs78n8GJu\\\\\\\\\\\\\\\/oUfyp3RDp246CaqwoRDwJT9UjYoapc7aUS86rMM19AjBFR7bfgfGusDHl9+SfE3sPA0KOVfH6Af58c8OtupikPwLfDm0A9f5QpTsnwmsRrOjDPVlcM2zicp1sdg9B0cbLi5Qm0m2cKLaJ3\\\\\\\\\\\\\\\/nO1jU0Nd29NBE8H2lWWqyAzv533K9E8+BkxpbsZLu3VLr+s1u6UjUg3AJPX5hA86aW2LknU6Ktl4O8\\\\\\\\\\\\\\\/GBuia6\\\\\\\\\\\\\\\/OeDvKHJ45dPaz3\\\\\\\\\\\\\\\/7vQods83a5qrNk7rye2dNv2pDaEvMNieZcKodHxo4uuYxDA5hUaTpMyoahU1Ju3mynGuQ2uM9sHJ+HdbmUWE1E2fcliaUIh44g404WpIG9RTMIsqDvaJkSZGyCAi5RZc2YD6aXN6hjXxLhuUC2zlErnd2N0\\\\\\\\\\\\\\\/lKox\\\\\\\\\\\\\\\/yxt4Q9orl9CmxzMeO6J2lwYB\\\\\\\\\\\\\\\/3qstPnM5FUHwPAcV6zivZ5hYnMUIzYpOGA5er4PFCfKj1Cfuv7gQctvSMmG4ZNd3VVazjnDQWEe9ntVQN6Th4bq1RY1bLiPIiejCcOEIGXq1ACEXMnCQHkyBqEHeS\\\\\\\\\\\\\\\/8FoIPgD8GglJHZI9raqgbgkCo\\\\\\\\\\\\\\\/+eUKhcZupvndGlephBZOJ0nzUusJO0fjaRABUNXIiGb8lvu\\\\\\\\\\\\\\\/HGkIpGQLFE5n0nSMM9iCTZv0swf6euajI6PhYbA73rVTIAw8a3M9UrRm9\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/1GS5eiIvXzvEZaWLdSBknvy7HxQPX0bbKmXiP05uxWbsOgzW48aM0SChXsc3ehdOuJTRc6tLKsYjIVlMkCbTWE8ZmXiVGSBkpYcEFmlPVqt1WHe7I0CbJbJkHD0dmzjQwYE7YNE3ul3zh61Z7yVy42usL6djD7amWHg5c5IgKiTVWhbDmgWk6niMEryfg5HUxluZh0u48JVFCOyWoisPD6C7h8XBJcgwHqk8KUa0pmZ638T+kPNBUtWn13J7vPzjtwR8TA1AxeVdGLE\\\\\\\\\\\\\\\/KfdKJm4Y07WgrkDI9MfaddXWu99VVv\\\\\\\\\\\\\\\/OkOrg5l5YDYufxN\\\\\\\\\\\\\\\/HevGWa4WbO2dwc8AhlJ\\\\\\\\\\\\\\\/aGmw0MAaXlU2YXgYrz8MvnaAo\\\\\\\\\\\\\\\/LqKbpWcrDnn1st8THFX65lbgRRvPoXWIkT7vHvrJ9W9Whn0nEP5iA7dDxRHjmWNfSnMiJYRRiRijh+I5eRQiYcu3wTEcrMMIKJKjuGjHWrATRzGNnaoHNBYgQlXsmW6Pn96GpoFqtihQuyfBWBsmzKli\\\\\\\\\\\\\\\/o0yA3oiNt0Mifeg\\\\\\\\\\\\\\\/O37quZV0fFUEMwU9JuQBcjKXk06oUElGStSP3odkGhwEgp7StEkoE9zwdoKlncej+4UIrEeMkZIazONplFnFjttyZPsr2pc+8HHsJHSwcY0V71tZxy+3HFrYEK6YIo4uIqBPJWgk5w3LdR3RfKVkpvJU62wRXD3yIe50dGBRrgtTyG4agYu+EU3igN77rJHfuy\\\\\\\\\\\\\\\/MGalCN0\\\\\\\\\\\\\\\/MdiuSsaGNLvWqekV+TscNHTU6dfYkRrVOpZYGBHZolUcStjqV45U24xFRAYG8QmizO8dRgK4o7GBUBDVsZx+36HNONcYESKN+4dolqHKXo6xDGGuwQGNw26QZa+uiy8rsXZ\\\\\\\\\\\\\\\/Gob7R1mPcQlY5HpliqByinDHTdQG9aTx0m5cgeYHgE36bPxVvwZ6K5pty6y0lEu1p3f3np+HUbz4DWCvT4LpSiw0WcO7Nwd3FrxkS3HbyjATs12SMaXq2xU6WowrQVsy\\\\\\\\\\\\\\\/fttML36hk5P2cYbP1F5CQ4VycHfxz7Fl4QJhRWWho8mesB8qDd3CN3hJuaM1FblXEcimbkRAoWRe5WCp04WRYwhLMZFKUI\\\\\\\\\\\\\\\/Dsm5Dnq6HK19Tkb0C9T3WABhE1HIQZRmwQQeFfXzj8rmHOBbaCHjiEERSdosTV6POv2Gk3fSGMxwNY\\\\\\\\\\\\\\\/RG6UqwgBeSx0kZLNeKU2nb3jYOg37YEvlkqRzHQGTM39AbcK\\\\\\\\\\\\\\\/UtOkqzaSW4MvrdeTtq76FY3nllOT7YsRKgLl3X1ca5C7hoZZBZtfzr0CQy2V71gKnA9+ZX1IOD0gKWeMRtFxdn36XEc50nP4qokaCc9ECZf1m+ovfGXiGXOF+B65eJB4OkyJvNyfoTbMHqKY8b59AblfXyNr5dIAZgWtlGPLOgp3y9XgzhxpKLEW+isnmCDRXJJ+T8lzP5YfBQaSWPzrtRbDmPAaWiC5cWA9oCNzXtoZ9bMz+VRapaJt7Y5Zgnmrrk+4U2xFuhl\\\\\\\\\\\\\\\/WHX+tOzmiybB1YVeoGgKfer1gBuZPPlMLc3\\\\\\\\\\\\\\\/kCOox8CheXGwgdI3910nNC1I63pta\\\\\\\\\\\\\\\/3jeJ8DWN5JYOahmv58Sj8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SoC7LI5u\\\\\\\\\\\\\\\/GhlLb+Uup+O6w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229f2e03d7c00ff3a3b8f4cdc0ddfa5ea87d7d4ec40e2be163d6e6fc97e4a7cdd2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e006680.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e006680.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006680\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006680\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006680\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}