{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022m+nicBsKBWYZJwI47mYOoHhpi66wHJ86p4J0kD6OdOexOhpxpxhvW7FTz9r2\\\\\\\\\\\\\\\/QPTQucIH5hoDOHZdOZOEgaCCgoyuJQo+M7q2bnF1GH64XSOgO5d5GUOF2NZmg5YFTOp0hblgHB48CxEDVqoc\\\\\\\\\\\\\\\/lDXbr2s5frq9EOhzKQmotk5hUqVpW\\\\\\\\\\\\\\\/go37KaJ5eSFeXqfVNqS+NnGlsClketGWRWACHdGBRlhaer5uJ3LT7WHsQfFWYJpDNbe0tDRTbrtbjCpf47TjUWG9TmURFB9ZzGDO4PPqisbBxMv9f1cki76baX6XGSA\\\\\\\\\\\\\\\/OECdaBQsSCcdjZ4a+D2DKPOQqI4pJTw+489qZOa+9qBbMd6SSybXL4K32lH36ZyGv5r9l3+Wy\\\\\\\\\\\\\\\/aoAWtez66cMchP4QHfai5Z1u7bKzm28h39P6eVZfijbIbryLob03e+2npEnuvjcKuQeeRL7DxFQlBb3bvbVMKmRs0kSyAn4m2nJxRO2TOCOELepycyzU8oV9FtknZLfMd6y9hf8cK97aeCTwyBCLHfPGvB3NMV5EmXgGkZN7j6a6GBFXbX+IGsRqaEm\\\\\\\\\\\\\\\/XIfscId8KxbnbWEgOEfGVWot4t7pH7fv+1c66vZABlHHLKr89rnyQbcyiedKU9W4VcFFLXeL5dm9s2THeORfRImlYvRGcGNivgLr+skGuiBxobHlWWtEnKxTbbI4yIKNhqG\\\\\\\\\\\\\\\/FfZfz\\\\\\\\\\\\\\\/C9ymfAVYj4yBbOTNB6IMOluqlslI+vC6bXuGPXlYE6gx6SLca43HTsbWE1lrB67SBc3pkeOiO1o0UT97AIuGGaSu7mcCfa0g+0WPOsxmso2+YgeugYkwxvl0i\\\\\\\\\\\\\\\/pEayDOxyhg8HU0HgLlomb3B62v9sqACM9t\\\\\\\\\\\\\\\/Adc85Yrt88U73Yh3bcNxXKQRIM7dGcn5r5hmuFz8VXMAUkC4JhYi+h4vjEyNVofmFK0mpJe9i8frEeOfCg9LUpIFCH00bwRtEEWbU1iqLk2IAOmnLjCfN5YUtzFruLlmhYQIaMncFwlg7Mm04B8WnMO8TrV\\\\\\\\\\\\\\\/2SDc46HdsOD13lNY2kj9gbdmT1YQDi6SMjp41JMDXLA9jzK8MoCQ7qHEOZn4bSUUP7WkJEIorN+FbyqNtf0OweAx20L6GG10tLxtDnUhx84DqkGRVsLBl2Ov7QwEnk6+\\\\\\\\\\\\\\\/iBEb1IuU+2\\\\\\\\\\\\\\\/6xQXt9YsbuV0h1HeLRIEJay63pXbe3UgAzgQ4mcwxr6XOBL9+\\\\\\\\\\\\\\\/w28gUDmZNRlWkdBQHhu\\\\\\\\\\\\\\\/4DQPXaR9NNSO9AfZzkx1TLpa5g0incia9+qIyUumgDqAG3SqtFbaE9r14rTltngVpX4RJDkUwY05QhdpPGINwFpZsQ9jZWnxHhoD6ryoLOH+B1cHYPrNhlDD9NwotJl4JtWUwe\\\\\\\\\\\\\\\/lu4Lba+ssK9fR55XNQ7q+eaxSZeyeyi86hBj0pnOfYpkM2XlRv2WlpfELcwgKaZslW9Kv9Fq3U5gurTngx0GxrI3yqsS\\\\\\\\\\\\\\\/By+uJmSGVM3cch6tHpdxEGZGBCoRQczXMzpHh202a3ucVIlBNCHlpYmZFbOkvgs9\\\\\\\\\\\\\\\/sn52O4BEISgqp58FPlPT8CzCpEeImP7vMdYq3E1mrezbd81p4NDguo3uSxPxtVz0k7TarXOD4mPWChyWMo002iRM7vsDBLCFK8dBu+h9UQZOT2ggIkabp9dSwFZ8B7J3V+D8OzoMx+oc306J05\\\\\\\\\\\\\\\/kt30TdNCjt\\\\\\\\\\\\\\\/+BvGidofLP+vy4f3cWqXg2kAtcC3mHfTh1iAOjkUoI+Wra7k0xFZ+lNykEsW2f6q28eu0zltYVBWFXVjyJp38Ihzbwe6HpKmaAIYMtdDaJTPhrHdzTIxn3GVPnuuQA0Hc3w7Lwr\\\\\\\\\\\\\\\/D7eFatnyNk4\\\\\\\\\\\\\\\/GNDuBjRcEaysX5gs\\\\\\\\\\\\\\\/uJsh+Q7X6P+v0\\\\\\\\\\\\\\\/t57nzuiNX+zQsaf7uUGOcgRRciEWOVwm0BrmbL1EVR1C48P3S72+i3lk4TZJdhKvyb3FzE\\\\\\\\\\\\\\\/yM9l8AwWt\\\\\\\\\\\\\\\/cSLclWRDqhw8LTGc4uhX95ZyCtCld5E59MvPcgLNbsM9KtGdWQ0AbjWr9qYiIJlbm6d1Ny\\\\\\\\\\\\\\\/0YF\\\\\\\\\\\\\\\/O7rMRkogjloV1YcZBlWSWes35yZyLijFUiSxQzhrCpDNNppVuyJ5lJkhe364nP34GZjxA+yy8ybfUH7\\\\\\\\\\\\\\\/VyD5g1oJ8R5HYBpAb6fjNh7HvRKqXwXglMA1BBnoXgG5SIc9LFzsz0z+\\\\\\\\\\\\\\\/IA2KmtvGA8Wxs627eyk26PnEM+jZZZRGiPfR9\\\\\\\\\\\\\\\/cob7WQGcN5rBPY20nNlsjzRqO2FI1jvu5ohGEOTW4oSGMA6ukwco+tJ21Xhs4WD5DpzBVrbrAUcL+BbHSPKBVvMJChp4+7wcQzNKZG8Y2gY8PBS2VvquV+Pp2rMSYHXUsndHq9wszCrsZDoZiXiFlqmEgUocmQ4Kxc1d\\\\\\\\\\\\\\\/7US61aLTwmWWBMGZGxi9cpGHbJ6qwzMYQdF3I+pt6heDIBbR\\\\\\\\\\\\\\\/bXzX7p2y\\\\\\\\\\\\\\\/6UG2EUa0b9Fjwvu1j4LUhuRFuS4THMqr0m2dzKjFnJy8BvRxoNfK9DhG1d5581zIDph+eyd0xr+aObX4N+a2l7HCt6CebbGpAsFpPJa4Pog8iEEC9H+4O04dzib5Aa++ZxdOWgMS15g5KiiMOrvuK277ppM85kujR7tpCFrRpxGHOTZWUA0pFiR05OJb1onI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cxbFevTbki58NsBKdue11Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d0006e87a74414e14cb619ae97c0c9973c208be3c7012e24d600d3bd06e6e102\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e006262.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e006262.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006262\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006262\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006262\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}