{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tzg\\\\\\\\\\\\\\\/EhqoPMSO6YWi2aSUiD82TnIe6OmoMQz\\\\\\\\\\\\\\\/rSqD3B1hnJQRXhb4Lgs7XCi\\\\\\\\\\\\\\\/ZHjwQkkoGh3HFGlXQsclAfQVLo08hBhNDsTtdwL1LH0KRxvIadAp9Q8X4Ni2UXrSpxjuWyLtvgc45X1bfMQb\\\\\\\\\\\\\\\/Ik+fuLGu0sbRPP1LzA482gGqBIXV53yMgPNxLP7reGP4EXhXM2vumIdipUTwQLka+09FJlK0LXwKTIaIvg3kyh67hgajLjVfe1r4KovGiZZmyItSgQ8Kq6R28kIuZ6sFOrw9OLNRvkkXX8dHS0cZquwhlFps47P+kaViv0dlhn4KDlBJEdMntuBV\\\\\\\\\\\\\\\/98iRqTxKwtmCkc5\\\\\\\\\\\\\\\/zR3ApnaG3sgma2LCrrmiNeEpOs+xahGkm8NnhS02BKKmJSq56VtbPWt0tHD0VK6TzR+6sl7jZP\\\\\\\\\\\\\\\/cBQoB\\\\\\\\\\\\\\\/6ieX7JA3T+4Y1nFvSwmG8jOWvq08vDuG61WdGwUgm7Ldatpw2dbkzgeQRzQ+YUzquuwD43IEKuOpfUkbZpcFGi5zcvw0x5CRFwW3dZv2s2QOG4jKgXekrpM4ZUx\\\\\\\\\\\\\\\/jXPpKHTBF3eQZSUWCNvz5tSCbduTQW22sGK34odF3d9UixCeO7iPRLUSjgftYL1Xb8e2B9h1c94oigxd1nbNsneLbfcm8h3a+vLVz3m89AD66pw11WpG9XLncxqQsYqYC0hTVAeKh\\\\\\\\\\\\\\\/QTSlKzr5M5fEndSTXGtrotzCaPvoxBABNsmBffMG1NuZzlYORSZucFiSiP2BgnXByjZIrhFx617XZWUETTg5SVCjqU0SoaOi4YzgDB39z2MrhjhdjHJzzYUyHlnd6iAGGTkJlp9\\\\\\\\\\\\\\\/rxHu2q1lfTqUTU+KNLPfScIXZze5sWPS2NL9YwCzRAMTrfqC51OvRPN4DC3eM0bRvb+STb0WEyfpHv0ahRAE5IXsrdlCpwyAxWXX6A6TwDkDLvDFIRGOI4ccTafg+MBqG80XTSDg\\\\\\\\\\\\\\\/QWT2pb9167x52sgs5dmGKLKwoDiI0\\\\\\\\\\\\\\\/JBrzBohdPOA3Du2n0T\\\\\\\\\\\\\\\/zNltcdY+BKT1\\\\\\\\\\\\\\\/nUPn\\\\\\\\\\\\\\\/aRqeNGyfzNjUxneV2VLRUWQ2hZoAz5SSEitt\\\\\\\\\\\\\\\/kzql37C6tU\\\\\\\\\\\\\\\/E+xv55GsHFa\\\\\\\\\\\\\\\/1W3cAGT6zmz2lJcKuwG1fM35NfG8nrq2qYu6E39yKpatHdPEGEWuOIj\\\\\\\\\\\\\\\/U0twW3RTygM8WCCQGmgSkhmwnfI9A0fzAD5Z9RlvPZ\\\\\\\\\\\\\\\/rYE0hGXZ3KyunlUKG8cPAdxpMCDQ2Rpc0M0Dim4isHLrJOkD27XxPyGw4wQyAO7sbDNVAigQhncVO4salW6eYmmE2z3MD8KezJYf73TQxYHgY9Ic3VQOcoNmsd\\\\\\\\\\\\\\\/jJsHtKUPn0VtkkBWp8bgmLW7DIJpT2iBZ2AOSFPsjvf8Qw0\\\\\\\\\\\\\\\/H\\\\\\\\\\\\\\\/zV7S+wOzFFKDqhY9KRNRxLZsqPe9RgDxF3jluQwBTaZIpeWs+6qFeIMQe3HhzzKHu+NKNBYWRnhSKWpvxFpWThoZO9RBsjHw3OgxBovWzaukGwki7TpJb+4FI9hmIKORIQ4XPD2Mu9JRgkW3FlAiMwaP8du7+Z7B8gwZ6J9FM04ydSnQspkg2+9TlHy3D1zyts+6QscFpdC0ZlSlQrdRPhxQcWlGsbOp02rjzaOxrxLWAKNbxGhKPrHewnPiDRVpOnITV80BMm2ndKuG6UgIuMncEtbJm0hAGZJjGZdvxgj53QXVyr0ec\\\\\\\\\\\\\\\/Nx9q6r6CGv2d5149+j3pgHtX3LiCxsMa4RdKUVCrCOAwxbC8n20g3Ekq8gXOwbkIsZ5OEO0MpsPfcftOXxPAtq\\\\\\\\\\\\\\\/5aVIgbKxEYkfbJ88R316Ab\\\\\\\\\\\\\\\/o1Rlq\\\\\\\\\\\\\\\/W13kZdMtT4QhAXcgAY81PdcZEd8araOKNwMSYY6oefH9R7o6InZLy+Nu0D7IvBcyOFk+qDwuAq3Afk53M1LfnxNDZ\\\\\\\\\\\\\\\/VQ\\\\\\\\\\\\\\\/ufIRAEWHA8zr387Fw1cFpTTyJV94TucryOwTijp3+Vdvv6DxMgiNfm1N1q3ppkF6LrJHmRUx347XTuX2v2RrdIxSLaByusGgFeukZIfLmF1G\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ZIHN3DhqBqegKuuBMiHvdTuqDrMvdGZOPKhrgTF39Y98Yg2cc2tkoNB0UibKusHypMx4DvDCT1Kob9g5toJ1MGZ9C9R8ieiG+0ueEiSb30q9bTTuKlU\\\\\\\\\\\\\\\/ZnGWwNRGgcWxhr2aQ2H+XHSltoySo2xxX4pUYV7HT69Ygi+y30ptJ1M9JpegucE8J4+AB1mTdQCuJ+UuxyyHWsqDRtl+0R1zquT2aKT3Mg6TRLMYakQNVAiJZ94UJtALcT8IS2WVJN+rbLFgc8OmiP+MMXmhaMDaMItBfZlIvoSKNq9zN7DVxYe\\\\\\\\\\\\\\\/pHC2y2zcy8nCfCNSmj\\\\\\\\\\\\\\\/m5AEN9Td1TF+vJLwXc480UsrIQBRbBQ+zqnQTEkjYGA3WBNZoTvBn3YpOnNjid69zi32YdmrNGEuHW5oA6PCmygxqaooOpjlNSNOC7nNj4o0daayqgFTTZvAJzJQ1ZVwL58Ws+ibkA\\\\\\\\\\\\\\\/NDLbQtbf+qdvlfSBGbI+e4ozu6NNp8eAC2dZKHNE2vuEJa2JgbJLmqQkaBh+A8gi++lyOEsHPRmDSYHGldtc01tCKFoSn9TQN3PZ9KeU1XPRKobGn8Eo1P066qHssAh1apsZapxdaqRhT1rv\\\\\\\\\\\\\\\/7HyyOODbzc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022y2hRgh3IWCgWtrtFZIjJkQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002274063e7b9ac3bbab86a1fb368d41ade0f7f3ce4ce0e3591664e905543692a49e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e005532.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e005532.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005532\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005532\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005532\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}