{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Vz1FFRKAay3aQNa22kMofovTGwUoFwB9N0QlaHW9EXeSjNxHN5MildJUOGSsAQbbgxjzBXjHNarRFrR3gxsVzcIFWp5IUqGXbBA4i1WLm+RKR55XwwoilaAxUeXLmkEvapgRKT8Xaey8wnP5dafMVqy76zlOpr4hHdo9TnAsyLRvAiyS3eDE0lMt+T9\\\\\\\\\\\\\\\/KG2124NhQ7q+xmye7Avofz\\\\\\\\\\\\\\\/xDdyY2n6OZGSj\\\\\\\\\\\\\\\/YQCeiXGegR0HS+vgBatrSDW7YY+U\\\\\\\\\\\\\\\/Hw5LpnnesBx62GF1nIl\\\\\\\\\\\\\\\/E+awtkeeYgiio3UNg188ZlK2pAcpFRcrN0cLqeJVea02YOnd7AiBr\\\\\\\\\\\\\\\/GNdF9MoBT2wywLBF7OtGY+VScEqL406N26e4qsr+Nri+j4iCKsQlxAyCvEk5tBfHwwKGUObL554jaY1SJ7ErOrFOLEEgTnM69LXbLFd2xuF9HhjqiYNTM2AOZa9XG2UhGMVCLw48dN6UgkhQgFZuAcDo0f6Z1e40oRDXJS71LlD8QqbU3H9wgfmoOPtXIaolqdo5fZw1p\\\\\\\\\\\\\\\/zLlWjogsV0hxX4h51GDvfBpkE2pM+85dgGPr6GgXIkIchy1fEDf0yliNokd9QdvZlJRbx5NHCMJY7vXjRsZgT2cyYBStfK\\\\\\\\\\\\\\\/LHfqo5jyw34sTvBRxmwy2WRRJS9ZAeKY\\\\\\\\\\\\\\\/yLCIgpqy0N8kFKuWY3Ta7GDnKjo\\\\\\\\\\\\\\\/W2rSV2D9q6g6DUip6Bo8FjOOuJlzDGoXgJScUbf4rflqNDYapLBts0ppCcnMd3hJSWkepaiZv66RvyhGB4wlGDs\\\\\\\\\\\\\\\/WFjlcI1Nii\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/w9pBG9x1rzxeD2J4f9NytFDJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/3cjjhO2RrMJM42BlDcf3R5yg794TZ3qwakBydj9Q8f4uf1h7G20vByWht2kPylEH800J6EvRv191+9r42udQnsiA8cN4rUY7MfU\\\\\\\\\\\\\\\/mMa5zJnowKjsbTAheqhgqlLxZm1FbwGyCYXFVRNxpLuPRQdJSNyB9y5gDXYPhmCrwkNFqgX8majnYSGj8OgNdqLvY6OxKLcr0bGgER4gckVepv1Z0oO8Ps96v2DaZKYM+ZqVccGiJjXLNWhhiklNTaJkLdPQV\\\\\\\\\\\\\\\/mJZqC04Of0JT5lfZaEVyVIVUpr9WjxcWi+HvGBDKhYcrm5eiuZSQ3ibRYIvtkMrHrAqSgz6\\\\\\\\\\\\\\\/7jLck+gN2T63qa4Cv3pPRO33PFIxj2Ft6ycl5g3syTfDLarCdY1s946zG+atYItSJ5F8vut8l96yuOJnOL99D2LHY6zWxUBY5RfsPUR16Q\\\\\\\\\\\\\\\/+GLYv6hpUvBMky8rVtwR8romcN5tzNJjE5tqxid7Ej4J+6oJrK\\\\\\\\\\\\\\\/AlEBijUPqJef68mb8r+75TzDW5Ok6+KfaWSYgip6En9pbROT3o5JbOhI1rnKabIpQlsnpN21i1AGqOVEjfbnsr3DQKMEzj25PuwX0d5I0QgDW9BDfUmirIXeN3ocQ5L67uvFZQhOFqHFgr+o0CbpSLDr0EfkztshkPcXIUNwKydDfHUHpGb\\\\\\\\\\\\\\\/x3I8jmSQriZJeYk+1SIZx2or85\\\\\\\\\\\\\\\/AfN\\\\\\\\\\\\\\\/50BSIkkvATCpDOZ40YCwOR6Qa1E20z0z+1JjEw9YpKOtyma+Rjy2avlnEliBEORb0RcTi9IpQLWpFdlcL9ZAw1uYcE9o+PadtKoons6Q6\\\\\\\\\\\\\\\/cfch4TrrA6c1Pz2c8FPbJHXupSSDd3SaeB3q5SIeJYQFzqVyGeAIry8ZZLE\\\\\\\\\\\\\\\/x\\\\\\\\\\\\\\\/lmie3VudWizDi0OTKB\\\\\\\\\\\\\\\/DjKiDosP1NP10aOyyvDiYMG+RBiHImxHHAXxGZdEZYSXcY5oZoUGQ\\\\\\\\\\\\\\\/OqVpDikUt74zeWfAXAVw1JSX4WCPdC+PL8USs2BaZhye0weVLj8vK0tf6xL2WhPksSSgXmnHk1j7EohxFACC8Y5+SeOK9Ls0wLRq\\\\\\\\\\\\\\\/VNQGpo1+Zrd7OwmU20vX6nV7gX92Igp6SZ8qjHwfCxPIhXcTu9qhqppNkkNtpxIrmaLVKrvghvu7EIhshwS8YCkP33lp6tTauAzh0\\\\\\\\\\\\\\\/NepcOholkgS3UPz9z3KzvauJHJh72KBOnoCKnwYshtXdcWdh7nZU6nR5GKDZvuTh\\\\\\\\\\\\\\\/ercwRurY0JV96yIaoFVJ4xIdfHKWcvij9qI1qpuIf9bexmCqlKYr+SX6Z5VDKEhl5ixhSkGezmQ8LzQdIs0KKv2aTew0dJIh3QTsNbXJe5NJ+445kGxyt4iTum\\\\\\\\\\\\\\\/H\\\\\\\\\\\\\\\/rOLea+RPoDkgY\\\\\\\\\\\\\\\/YH848piLPMar5gRek4lOGx21oG0mBp7KKq64hshaVglvbG747Z9Y8oEttXW73b73AiKwGC7ZkZMJnBBb+gxps0BGIvBIyHwj06uhkFZs22IAkks64\\\\\\\\\\\\\\\/K7Jgbo\\\\\\\\\\\\\\\/9vKHW+xf8zoc82pQ+oKEHTrthjekMHpZf5ZLnoRfIpdgNYAKeWpm8Rmr2vNaLkITB1G+b6x8NBVMaCPGF5MrJBStEEwLxi3GC2lNg2P5CkC1EWLpqDVVqiQNCNhg1st1EAGW4yPscaYdfX8hDvIwjRjVYJOpREHcYokx3gT6oN4Zj9+srJBRFBYS9Jbi3kscDzrYkX5Xk9B7hX32qjZTD\\\\\\\\\\\\\\\/azkpu04BAKOy9kUx6jD4qBDffrrGN+EugY7uN\\\\\\\\\\\\\\\/WaYzK2RfAzD16qrLLgnuOXmRjlhaV5K4bGFczjwjEPLKqIOJKbxWdMlZhTWc1nK0uLU0o=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221JIFtzGPW7UifVFfSmmOjQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002293cb1af327c827500290fa4b28ebd0d07c7d6fbba81003f0b5dccd552aedf81a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/39.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/39.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0081-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0081-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0081-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}