{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HMpwERrPehCikZAtBOj8tV62lPVZSQtkhT2HesYJy1VZZJBBT3\\\\\\\\\\\\\\\/8K10onUGhZ+hTdeVQhXnMnBdQEjrIWTfOcGXJTanj6DEiO3MqGJEfnHdoKKhK3UTi2p2bH60286qf\\\\\\\\\\\\\\\/+Ta0bDcyym2yZ0V8cwWMdAOtEKMnkSQybWCsE9D3E+NJY7viJ1P6MrY6VvWllhHRp2BLyqBV+Abyw\\\\\\\\\\\\\\\/pURsdNS6XKZgTValyzHKkZeSWzMbzkOvzMVfBMVyMVXLFAcCwy2Ja3HRGQIt3950Btbes3AOi6qtlGkSsUUrkz05Qx\\\\\\\\\\\\\\\/xC4JzZI+6lQv0YzFmSABwi6CaPijPr+wfuWZkBBR48qvb\\\\\\\\\\\\\\\/o7Nl1x3lGe3HlZjbRDuXVMUZc3UKWa634QYr3M4WystvifE2AamhY+BMLWxVuMfmn9Pup4OBTTayToLSjlT7BXtnj0ypd6XG7CNHwtIZ4Cyu8YnuwRHpVwMKetWrkjk+a135gSz6lsy+X1St5vJMaT36KVkFZcTy2PrAtYDm9Ai4SxZLojIIeiFyfPmm0APWcdPW0f4ZNSl3L8V1Vq1vewqvwJgfxWbfDFnDwgPcaDk0EKBi4y5nPIzDbrzugalSdmhhpB01OJ9Q\\\\\\\\\\\\\\\/MjqY1sPMDH1c6Ewm2IVMYk40EnBjrwPtuccF9mjYBJ57nyh67O60smACkxfabUGBCdI8gACAVzJsFrp\\\\\\\\\\\\\\\/Whbjs9ORWSImlH6vTVfUAYqLQf9D8N4kAL3M3\\\\\\\\\\\\\\\/F1lgxO8si7o\\\\\\\\\\\\\\\/OGymFvUXxCMKDzaVf1iPQ4N50jxlsaoxVEI1nFKWvZbzraSnOuEcuiP4TEav5NU5nB\\\\\\\\\\\\\\\/pxPT2635cQgKmjb8D3bpOH0kfjr4\\\\\\\\\\\\\\\/YpXFlBcR0N1UoV4y1r\\\\\\\\\\\\\\\/9rPRKQEK2ezzD9PgFaLuaS+tAfZcw6EU4tSGUZW8WLNp6wPBGL0gGXzxaR+CzmLThp+vDALqRCSg9+qxExQ3YuG1GiM6Q0414sWWIn62QK68ECDlG7oKNqOGbnCYdgRubLhtuWmjt\\\\\\\\\\\\\\\/O2sG3lenpTjtS0hkKzX9ASqpLxMLjcyQSM1zSBp2cOpH50\\\\\\\\\\\\\\\/inYf\\\\\\\\\\\\\\\/3hLrnUajlHH9K9XOlyPoG9Bpydd9IoNum33vgvdk+2Tr5\\\\\\\\\\\\\\\/UfIGdzNn3LYctxP7Awek\\\\\\\\\\\\\\\/ONBPhZhmXpjEO8Xij5GKnJc+03f7s5c95iRjCA4AN3rjMJ9hOieTKZftUZkM1rw4xAw6GpeWfPtZozRR370SA9SynISBAChQ\\\\\\\\\\\\\\\/x9Ltz291X5C8vb2kFbbcWjxdGMk5ZmwSsnQoeXDnxjIWO53bGzRokfPB0pejjPs5tjzNgaVO3u1c0RRLaT7FCPbt1VbwXxjksvc9u7qJ2LZYqm3M5kYGQ+fw8fEsvHX95mplcAkW0yXa8KLzdwnnZvnvyvfHin+wM3KuvxBe7vcUSf5tw82bQ+GUqTDKpUdGQN7bt1hJgbn1BiwkNu\\\\\\\\\\\\\\\/mzdv1BFa1zP+9lZc7NJSBFq2VBSV7KdJCLZH0JV9mFO4Gn1x3n37FKfaKA1go45Z\\\\\\\\\\\\\\\/qahiEstfFbv\\\\\\\\\\\\\\\/qe9pvdfrfYGJFj0ABfeF2W9Oolm4bMVIJNM7gczjN05zE+vbbB7QapPzNNeO6pKe0WztfdA7tQlaBVCb620\\\\\\\\\\\\\\\/yhDK6GAxalvo\\\\\\\\\\\\\\\/CHKcypRudXQqE4WRw2cbjtCiHNn\\\\\\\\\\\\\\\/rScsCOPJSdfgi+053ATvdRk5XLAXON0bmwsflO7YkFYsp1j7GH8ACaL8NVk4k13+nl9XEERc\\\\\\\\\\\\\\\/XZCET9PNFn1kHzM9ZA9cY+AFDUuQyDn5ZbYI4zHItsHUm3Pb+YxMD0a7pjvtLu2En3pV+bp13ysYe3F2723HMLD40GpvEVz1La5hJNQPCzQ6kD2VbL6bfYutGMv8+pquocABcwgiEe9cXLsGNlygM304yAHgPPNhk7wbv+p+5Nv+EVt2J2uBScz1RTESWMwMSB7h8U2EUpyHRhIFIWiyfVHtCKQ5iECAESu9z0QSs1Wchaz1IjHhZDZfPH2SxKHM4nqxTz5VmsVh9FpGCiYJJ1J+1Js1hmnXdLepU6HpIrdFLjhfsPGaQWanP62TtrvTB1Va7mbVQRAIAxTJb+KtdftAcx+QVlHsSXLHSv43pbkaVIbl\\\\\\\\\\\\\\\/BCmsm0xWBUH6rpY2BmZco4kPMoSFwqZ7hsfMD5HbEcM7Hhy3mNLiBG1vvj\\\\\\\\\\\\\\\/fhCQn2xpU83m87WSruVudo3SoKOjzBH\\\\\\\\\\\\\\\/xywTieCvm76d6SlZi7zs0Ck+rgbs5U0M5BK9JzJ47jbAMY2mD1PiaBJ18Upevn+NPCWl9f8NbhsNVgidP0uHHpfPkiZTwoaM\\\\\\\\\\\\\\\/M+CPjDk2\\\\\\\\\\\\\\\/KXSHu6gVrMWDRX5QYoQMbDkNCYsyfi3yGWqc2b54AjXNUorgffbQ93mbvIwGJ\\\\\\\\\\\\\\\/Mv2uufq61G1i22VFUYkdcw16ZTWc9ggNlfaGAFeFhEnLdaDnMCR\\\\\\\\\\\\\\\/GDPOLojh3x74hx5Q3Y2s6FZWQx1JKzu9Zsr2K\\\\\\\\\\\\\\\/C5mt8H8VxAIP7adNHKXi3jtAX09WxkBCfo5XKZH8qd1XBs1ZUNtpbp\\\\\\\\\\\\\\\/GaSFLu0iTFw1Cucy30kw1M50WJjWoJE5s1Mi9QEp8CsAW00acIcnAwvb+P8JUpg8B2Uou3tN7XuhbCBP8FPf+r2YgVrRv74EFoXYYVoxsUVaEBkvYAR5U9WUkjav\\\\\\\\\\\\\\\/wQshBJk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OtwAnJSlqdLtz0LugJS8Pg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222b850ededeebd055761804d5b6fdd0df7d852b1c70c3cf1cf70359bfdd6b07e0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e005583.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e005583.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005583\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005583\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005583\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}