{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022oUZgN+NZ2kFrsdi4NfGCTfSilZzxQs0MCibzeL+8jWFvH9gmvNpBsUbTIFuq+nsCIdOnx6kseRoIebvf9oODnZ\\\\\\\\\\\\\\\/cAAT6zEv5fgG5x6qU3\\\\\\\\\\\\\\\/Usk1QZIdhQ+nN5LkSOAQF7POz9jLtDHh07CjCwUPzfrQSl2QXpMQf\\\\\\\\\\\\\\\/LBJP4c1o7hxzAlyNBRkeqMxMtUXOyDbk4dX3dFe8ieLt1mQKN\\\\\\\\\\\\\\\/atdP1udEmKWBj06G4VgScNLjt+4TJi94VP1e5BbrFaIwLbLwx2Cw+0GwAMTZgQum8zZQeqaC0cdkcCxIfkLLClGIKF7s0zcmrpQwWb1hwOqWKpEZrOjmJIESudypCa938F9naEyJFyONkUlWhu+gyrESqel5k4vKcqfAN9zRTdaNpwBxNQKQiLC+TtOu+2GKaTrfkCCWwkdus1z28RLvImIVpaveQLwlfEoFVAEH5U3A3SbpYQ3xhR4J4oN7J3VUTw1RGILMDH3bc0YuHrvA21f+OvSvr\\\\\\\\\\\\\\\/EW45S0iiD\\\\\\\\\\\\\\\/8z5u28JZ7DDZ6MIXJiWZHBcwEPwZk5mRrzCopJpQiTMC5Ho62Jg2eAatFSmSs1YJpyBXiIY3CoBc6oDIJx1xZAsh+hTOi1N2E3T3ncvHg+0NNVKvmmI0JQ1pqB6gaVy\\\\\\\\\\\\\\\/LngucLUUtMJ+YRhTe2md7ZtOUnPARG4dqk7rLBZ+zUG3o3lAGxetpPISTB4YhEoFFljSRnomGx+kI3YyKCljdLJu9n1H6Q01d8TQlEhw+H9E00qWH3gq8Dqgh\\\\\\\\\\\\\\\/TWnnK98iiflaT6OtwuCMnhWRxOplO67miGkWqWvEaW+idZAusqtoii+vncQlKw2z1GVpxlQEkpy\\\\\\\\\\\\\\\/TX2p3sKdYwbI3X+hcuAEY5PV+OzJH\\\\\\\\\\\\\\\/K9J0EtNLsnHba0ziyM+iVFiAKGw+St+bYvXxC8MMOpkyqOCUDNN6zWHzpRLnZeuhtoCC3qNOshLDani8hzYgqZAHveJKZ8Cg65G98ynOY5K0jKpvM8H8VYAu7WOkAAuZRv\\\\\\\\\\\\\\\/lpcvXO97pvAXmRLcMB67cSxJRrjmFFwhi6XBdxlp8PjemIYvMSpfa0EJgbS4O6Hvil8CRAjDyXaj2Gz5Lv6fcwMbJNeS8Zzgx9AcKO4MLl1rEb8yTuSu+9603JxqUoTAu3hLqmAO52ryPZs0LTWryyISI3hxQFac9oP6HsoR7s1bVKEWEPid1qjfBtprhfvf0uGtJzifmy8eB7X8XSEmqIIDjKbRG6VuFAB+F6w9AcZ1TvtsPpfe9\\\\\\\\\\\\\\\/pqYfRFMYxcjRNeXbxtNdlpshaRzjnv12xbZEV5mug2HbH5R8gsJPUv6uzZsmwVR6clgWiLDsXR4o+rwEWubQ7mmCSjoXEfxbdCGmkxGA5f+v62XIi+O1Zf3LXp8hybFS0trnU+QA1b5vBMLB8TViXgZ+SLZfFqlIBKkJEUQBHcd\\\\\\\\\\\\\\\/FNWkeKGZVpvvIafV6EqC3il+zidBEEWqixcUy+vecUcDfmkMYoC0OSZTcl2nuAwC5eW\\\\\\\\\\\\\\\/7c+izsRluLiyoNMB7LsCFX2npNsIjBfmR5InbLkxH7bsbFD\\\\\\\\\\\\\\\/4p+lv6ZNrkRXKIhThqjiHypwIdgivbt4ZhTg9gR\\\\\\\\\\\\\\\/v0BuaKdqCK2secSYeFonRwHsq0aoS6JMCO+0B6ERb\\\\\\\\\\\\\\\/bAYE7HnhqDNWHgYzNtWXf9rJCqy4WPmUFRN9DjwbCQg8jAba7vSvVtLG6o29q8lJ\\\\\\\\\\\\\\\/rzFMNPwL8M7ENL80dlXOHrY+I3sZ7nXlrxSPe6pCA8V8p+Rbrc7g6bhAhztYvv5QWG5FI2MdUfbBHc1hiABW5xnEsSleEzEykpK+Fdya\\\\\\\\\\\\\\\/WkU22XnQ5uGH1PAmB4+rfVXxywBGRosGD4uhFJShr81fApYTbhLdUtGaIYd65lz2WwHUrDgQxIwUUFUHB8QY5uFfW+MnaTs11F5IGN33IgqcqbK51JCORtYdkAB5PSdAjUcJOQEgX8DQ\\\\\\\\\\\\\\\/kvfZwJdEc+jxEg95\\\\\\\\\\\\\\\/13g672UnDQqUHyLpR1+2Z0BRMSKtkV+FFhyUGKfnk5kZoyxWSZyC8NYLqyHCNpV6g\\\\\\\\\\\\\\\/ImUmJIv9hU9VtZhZDruIDiUk8bKjSIQTjD6k93NztKD7KiTZCUfrADxkOMrpNv5Fnc8GaS68N3TnDIGQmD3WA6WtFGrX2jcTGpEIXSKi1Uc8OLvy9R3X3oAtiZTV5KIkBgDhHsKkBH1cOdlyc\\\\\\\\\\\\\\\/T0Po3As5I4FHbl46bdN\\\\\\\\\\\\\\\/sXNrzmEpCf5CDMRzdS9SCrxr9ZSit95s\\\\\\\\\\\\\\\/aLJCQrYxEm\\\\\\\\\\\\\\\/3Fnpnoc4HQhzw59uiD63boQxBA\\\\\\\\\\\\\\\/9Zrj9VJiJfWHcZgwmVX7ta6ioT3313BRJFZub4M7HeCW9psk7psoDn26gjjhNftPuD690svO89DkKS3PDxfp71+mxWzsOfd3BRuKhhTlncpJcVTxV1DFt++omM0KA8\\\\\\\\\\\\\\\/keBm92tMK7SvXJMv1WN0ek6QVViOzEqmtJLJRiAPEbQ7aruKzAjE8Tbrrippiw5aGUTBsfzXfTGAzGY\\\\\\\\\\\\\\\/EmxuQ75TeE75WKOA\\\\\\\\\\\\\\\/tL8eqGY6yzDBaHYiQSfqduLCL9kFaSABwz14vYNR\\\\\\\\\\\\\\\/V2tk6I0Rf9faa\\\\\\\\\\\\\\\/N0h6VttqDsp6+93DoLTANwjcBl9ehEG1Xk+zDU56rlbdrm3LzhfsPSIxSYOdLhBMv9Yl8n+6n4ohWB7y4l8A=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022m8iksLkM7y2RZ56pg2IdrA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222a6b2624374e0d72deb37007b517862a0112f03d870f4ed7954e46668c342915\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e005560corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e005560corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/3\\\/e005560corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005560corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005560corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005560corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}