{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tTurYmyYV5DBlN3+e0aiZyYwHYuynln1fesCdsk9u8114BXGiu3HBfCpF5r6FJ7dhtKP8unj8bMMaEUMZV7ZOns7+lsPmyrOsvWFykrw3FLIxbwkvqDNFdnoWM\\\\\\\\\\\\\\\/jwMQnd94ioxdo8yXyamL0QkCbgDwLNEjF\\\\\\\\\\\\\\\/TQ7bpqqn5AMfrDl2KvdzGF3E4lKS5xKVsnPGZnwtmgd8cwUaYhE1BPvh\\\\\\\\\\\\\\\/sa5vrOrcaiV8sXnqoL3RcJvPZFdIXJB12WyMNYyCk+QjxeXrnrTtl2iPKGoTXA\\\\\\\\\\\\\\\/UOnyyrjn6mB6uOONipf7YpBC2UquPodBiQG6Ta9IzK7q8ItX9w4vnEvrXcRGTsaKcAKuu+k7LOZBc6++RGxtYhzWZBRi7I1opTTbP0THk0eFDbM01ZbtU3dzxo822RBSzVsjQVT7FrbNk78OHLLT+go53KWkYATkqPFRYl0+oz\\\\\\\\\\\\\\\/SBGjbTtu\\\\\\\\\\\\\\\/+yP26HzhJ+z\\\\\\\\\\\\\\\/WTGUEnc6e3lWjChm3Jn18Yk9s0Jx02OC65wqVQHHhhqMKulVJ8joWMPNIw7sBf72v1zEP0p+9LcPsKPJdhpJz\\\\\\\\\\\\\\\/t6qNDZG3FVK9A5ywhpc5rYtebelDz4SiADnUq1WbXQPZL\\\\\\\\\\\\\\\/aXBt9f82LDZDDOma0Oh+YZu96oc5OTsxbHSTt9nlkNATtS\\\\\\\\\\\\\\\/sC5QkupJAckbUEtTTTX4oN5baav9Bn8IV1tbg\\\\\\\\\\\\\\\/jpbb\\\\\\\\\\\\\\\/4Wnem0mXL0Z6cYXsrUNKl9qD0uJsjn9585xvYBXaMdqBBJu1iBCaoYLGFRQ2Sqb8003ogpjDACbKPe9Ym9CKCh977370YdJ83i\\\\\\\\\\\\\\\/ONCgmpTVW3SoEhIVQAKb4IShNpj8s1OH7Z98AA80hCyS3f+q3eo8aeW\\\\\\\\\\\\\\\/NpzLWJBM9HqrFvKo2i+tvxgY3Hscok9Iz0Q4KGxsMf3WzhOZ+Jz3slEznCPRsx1R3qZ42qX0iSN2+FV2GNIo69M2zL8ERp8lmSpmbvwDqozbw0ttHhgE\\\\\\\\\\\\\\\/nH6KtL4u6+MKU12yx5rHk1pOdSWNg71PoR5trTOi5ddlZifuMh4YtHzRLsJqA+Sf712J1EZe23GkR8LJvLQyraJtLZXevdVMZAtlvv8O5t+IhfwXKaGDw1aNVGwUkqQP6fFVdmtEDAilos9QbVd49D8TsFgUmyCeye4ea7hTzykGQH5oho2r8DHglD1256hpAmOyd22muvpuxqyQmpjs8fNCKP2TUDiN07YkrUClKk0J7Ic8tbjMGNqUN8R+PricoO2ckaR21nBf00QOk95JEC6r5KclgxeRiiBGaFt3HVMhNs9s0iBV8ovTiWyJpaLZQTLI8sx+pG++sf7+2ls2Pv6unElKqvWQKI52A\\\\\\\\\\\\\\\/v7dse7oLLO0IWiSWC5iNWJ2ExprFPoS54CGlVzr66eTGreM8R5cs\\\\\\\\\\\\\\\/3gKKnI2ndCm\\\\\\\\\\\\\\\/zM0zro\\\\\\\\\\\\\\\/W+sSqRSBa8K1A4v8KgFwB8pZ0xePjC33EmYna1VnmlAgKkibhM\\\\\\\\\\\\\\\/je0TS6ybx0iCtJxRRtPHjAJGOcLPTwJE2u47nvqbvvdF1q\\\\\\\\\\\\\\\/K4R6q5tbMZnu49KEwzWz+JlwEANwV5TlkR5Qox7zFeZidRCv\\\\\\\\\\\\\\\/2ow3V3XuSQL5IlHCCVZ\\\\\\\\\\\\\\\/w8Zc4g6c8XIT9HV\\\\\\\\\\\\\\\/Mlsb5f+a08wbaJuzC0r2mgD5nt3mX3hemBX\\\\\\\\\\\\\\\/cwn5\\\\\\\\\\\\\\\/Ou1yrfND1HRNIc87L62jclsLQ34qGuRtG9Ro7Elvoa2UkmzTDpWVLVeDLfMWOqzGJwPKOrjXfK2k8CX4tk0uTHJ45TJu6r1IXJubu06l+0b37NcNLcG93abLQLtpKY+\\\\\\\\\\\\\\\/CecMkuBkdhUZ7otm7f9TH8l2B2bxkd6\\\\\\\\\\\\\\\/+CVnIQ\\\\\\\\\\\\\\\/0G7MA+ps+mOg8SwXUivYYZqS\\\\\\\\\\\\\\\/XA0QXUaE1BfA9wIKI1hvzN\\\\\\\\\\\\\\\/q9R89ORkylJPoO\\\\\\\\\\\\\\\/GqH8qaiJxvVuhuu6CX178Rqs9KuphKwDtCHTzWjuQCiMMerDHX4E1xDJXG25jwM\\\\\\\\\\\\\\\/kc9CqHobTVth\\\\\\\\\\\\\\\/2b0XRzaBe0UGrJoNPS08k1qFtHFOAEB3\\\\\\\\\\\\\\\/yewuRkU+zfpLE9RiF9urrSXo3QpufKIkgthpa3GspPsqFWrGOPL3eTBOw7x7+1SnuqkfufSiKF99JWP4j6JKt6XqgJOG5ja7LWGmn4ILbt7y\\\\\\\\\\\\\\\/BXfS99CO2wkOn2UPQqA7uHbnRt0ajCLbRjw2iBF18cJ7kZqsLxlR07ofjqcobFJr42kS8wyCS2Gp0KuUGiRiIqmv4u6H6HFQ7tKFgLU2YIMJqiuylKP+2EN8jXqPMRThJTnNNuW0GO+hs3hF2+TcBBsiIWXyTdq4oh\\\\\\\\\\\\\\\/SZ4F8cLRByiVLbomOtbBXnbfrxGct7yapRpV2\\\\\\\\\\\\\\\/cIA75xP1bbkWeftLu7+xESFrwB4kD3cSzm\\\\\\\\\\\\\\\/ZpexI7gYxfEXGtqaK\\\\\\\\\\\\\\\/7ldMkuMwUKiiz1Qjw44YU7TBMIJ3l6CWWLNqhYVWxn+5x6hMLwwLODeYbE\\\\\\\\\\\\\\\/mW+KJQiydh0kO2BU3WwiBHFKHZhdclUC997G8LcXqMvW72x2sMsD7xNUujdSw72B26c7UtmwoHKfLlXnpF5wX6avOzLbLW9Tc4D3w3\\\\\\\\\\\\\\\/BQUHi4K6uffK1Ri2IbOTEzHFRwfdhLUJUw6iQq23OZU7p4nlJ6ACPw5f+rVu5ISSglZqM\\\\\\\\\\\\\\\/TEXxO6iYB+ox2ztBDZxP0SNPVzbpxD6jv6qXCBjwVt0BMr6gh9c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hJSWFCrvht1C+eHjtcZpXQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223aa59017adaaba662d2e973558575afde4d00c6376c91800101e445c88635d98\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e005699corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e005699corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/3\\\/e005699corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005699corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005699corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005699corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}