{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022XdmRITT0UiuS\\\\\\\\\\\\\\\/m3xoSzqxFfHqTsD62R1fqPGqN656ZxHyE+NA0HlGi5idwQ+o3BwuXsTW\\\\\\\\\\\\\\\/UxjVC1s4JlzKmOrG9ye4E\\\\\\\\\\\\\\\/62WxLTs8rcJCChY35V4\\\\\\\\\\\\\\\/BItjgTzhLl1iMjxnx1OpP\\\\\\\\\\\\\\\/VEK9WUBrFsWrKqT6JTi7FyqEG2gw4LKqO\\\\\\\\\\\\\\\/HW1dOjMi1yU83eECdx8TA3GDUrDcjPkopYkhy+LKbNONOX2e7uzVmEiu6jHfReD2SV98Y+QOsry0Nims5Rvk1pHYNvrZfTD+GmVSW1ltOL7kyQYWtmzbN0C0y+j+wAQTBhd3cZIjDvHuyMOV5Ru69+FGWrBSvH2mTGYQxLoS3ei4N0HvfFQURz81UDZnQgvXKJ9PiS0Z0DawPt\\\\\\\\\\\\\\\/xiR\\\\\\\\\\\\\\\/eRoC3mCsRjphM+TSRhjhEmzhEfdrPmYvSGwCFghLG\\\\\\\\\\\\\\\/nHNeOXxOA5f43oKk8XzjM25YP+U0HmaJTCe2h5QUXGk9ErZsqqmDcdzx8fY1jxin6nnFgdd\\\\\\\\\\\\\\\/CSsJoU8zkwaj8OAARdhrD3OAwapna1SuQ+tjeWqtfWWXTWx5ziMvjV37SSeV\\\\\\\\\\\\\\\/q8hFZM4Lv5fGj7ma6bhfQC5sOLD9r931dPR9YBEeOHO4xA60UwPS1tuzE0voj2pOZZ34aO9p0MH2gJZ8abMvVWEX1S3tLz6p1kayPZlfhDiqReKy+Hn6v6wSKmS+GcW4\\\\\\\\\\\\\\\/9lsgpgbyu67QYsNGA3dwcv5Snu2gIn7rKOIXRQMLRh8gwjTlxX1kVmb8Wka7p0LtzgKIGjftLRXbCFf03yXfl9KFFF1HMUYEaKa7prEColMIl0Uqooh9N+Bki81VNG5hDBNxuDo1sgG747CfrJ6wGuhfPwp1oKS74ovsIMfb88kUY6\\\\\\\\\\\\\\\/EIP6VO0iER4t1pGiEm9Srgfr55Geppzqt1mbML2dbpnwIt15Uv8e+4SmwMqOsXHtnT1nG1EyHM35m\\\\\\\\\\\\\\\/+0+8uIDr8WY6dVA2jRKBj8\\\\\\\\\\\\\\\/67mE5utt7QbVRU1QiY8wvcCEdqEpdNKgsMZTFUwhb0PLolcPrXugIBJ05vT72TUuD87xIBfnkXtK+OXIiHE4ChvqCaaxzDJ6wluj8OiZedB25XEZ5g1YORXPSaTE0ReDsbO87RzD0n3ebKzmIVSV2amaBCzGwTsuzHT4ZrrgvdCN4xjHfEFwYrzDmXLsdHW0l6UTa19TM9nNl3rFPUsbAFxePEXL3f8vo7Mm30646SXfw07ipIDMLQl6D0gNcyTZzLrRNZBkVeKPTmK+UL9q3qL4NvXCVS3jc1mQfFxgoHK+vhrgxvzY8ntt7E0Rhn6Ze7awuDyLHBb7QV\\\\\\\\\\\\\\\/WUw9tMLbLvRGTuUnETmtcbvWnl3EzpC6icmKFjgfp8\\\\\\\\\\\\\\\/tkFWPyNb3qX0MIybdu6bfNJ\\\\\\\\\\\\\\\/904NxDfEQ+VAh992UzgKH4ZNw7Bf8LNRMoeQJhzSTGNz9fCoryTWn5iJ5RVkbC1omS12eLqqduyNn2fm8rJG+TJI6dsUKHR5hmsfvHt+e8QawWip2uv1AEAaYNbRK9CGjREgtHEpbAv1t4Ss7R2T3WVo1ka9mY5Za\\\\\\\\\\\\\\\/MsbMbd88NKwuhsHIw3be8heGsiDUbLTlakbm\\\\\\\\\\\\\\\/fPLfjSUkP3vsTkokQnWTKE7cdQR0iDU8W3DswCBRXRI\\\\\\\\\\\\\\\/q5ECMUGvB3pVFJblrxzBfwAe8rcsSPuEdSypSveUj2Ej\\\\\\\\\\\\\\\/NZ\\\\\\\\\\\\\\\/WaCDe3O8kSd8UmiQju7iQNL7ElAaWiPQFZjm3cgqeQZn0NBGez0NWEve8Swxs3+htUVQHefRclvn1fJpPdt7PViK1NT\\\\\\\\\\\\\\\/TbGjkt4tjv5\\\\\\\\\\\\\\\/EOJUSHLWek\\\\\\\\\\\\\\\/n0+6lVzQvIomKwkN\\\\\\\\\\\\\\\/xQSBk8d7r+Un1vU0c3RyxV2TpO0xN+As1qOZ5UZjB3MM05ATyiGQ75yzNKlzI1OkYcTcc3oJw9GQu\\\\\\\\\\\\\\\/Z5hz61iq0\\\\\\\\\\\\\\\/FnI4kHfOFOiLwZYbko85pHoeZ+WbI5Ixuv3coye7+bzROYAlH\\\\\\\\\\\\\\\/06xfpmFf42NMrkgZ6dv\\\\\\\\\\\\\\\/vp7Ac\\\\\\\\\\\\\\\/YtnZrgn22lwPxh8urmJ6zLRg\\\\\\\\\\\\\\\/mig4WF59D0pBa7Q8aijcByO1zszzKVxWwpt4UEQ\\\\\\\\\\\\\\\/1JWZdSKBZE4GVtDCJ8P6t9dlWMuumIPilf1elXFqwVU2jS99p2rjm48GhwOonFVBIbAO434gAIAOJ9GgQCnG4FX3doNLbxEd5JF3iEdOEKFNSvFNGc\\\\\\\\\\\\\\\/QcdM9mxlzfVyiH3A\\\\\\\\\\\\\\\/MlcJ4Mo2i6BMQwHavFatpun6x33w1BDzM4dHjds7LNcR7+vZM466JnqAY8iim29UQ0AddLOOIwB8w1bg5Hgfmq6kF2s7QpYOFbX\\\\\\\\\\\\\\\/zkOLazbkeeF42oX\\\\\\\\\\\\\\\/NeOZh\\\\\\\\\\\\\\\/Ng0NkwGysvTctVyv66l3tkoBqoSMWsLj+4AWBCzXHH3UXB4NKFicM71xov\\\\\\\\\\\\\\\/oQtcwPv23VWB\\\\\\\\\\\\\\\/5hq98qYd5SHh1aHGfsA3ybeCHu5DwbbJ4Q0RT00tYyThPJyAhoGN3YfY+IUEm8uBQUSBZJxmik7BFB6ZqZ0V7Uy7O6yY1rzT3QTwVRVaJyLNHQHL0CSSzlFZptF5el5PyqzZFaaw17LWipbASo9smgaBl+lawm0dzTjEr\\\\\\\\\\\\\\\/XkMePvX61xaxxCOBBgCK89zHoAnQKTXqs0KOfVggUoAuhs6NxdNiSJP5MqfLufCeqjM+Av3HyO82qJMSRDrqGzSlPFZAVwWklQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022eyEe8V+y251iAPpmOSWB7g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e140eab9f3efd96753fc6db71bd003a29cdf11bf8635afdc734087a7953779a7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/3\\\/e006648.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/3\\\/e006648.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/3\\\/e006648\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006648\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006648\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006648\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}