{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229CPbCsIGwiS72E9IChoxRDxGqcvfox+GnHLpjBA03tuWPklL4XMnDOcH\\\\\\\\\\\\\\\/u07\\\\\\\\\\\\\\\/uoGroa7BdBmdQS7LnvUUlCLlen9KX7qnO7qktbXU7IRgZcPTXFoOXZFZMcBMWYsy2n+FmCFABJvBGwjn7vLP2BzPLtOehP0XW3sxsGTqXQMNYpNj3pfYkUOpNY1xTV82tffetT3ye8NQMRsswlyAbi5465NI2FkBuBK34qcyHmrM+B5q6PtET+067m0c6dMsG9Nq7AJz6Fr5uDtnNV+M5bAavf1PFQ6fC3cwZYk3s9VAtCHU8fuC130TDimRjfdkSDh7SH2hWkUX5qNbyQxMuk2oOybwi+xzjERgSsz3S0CO2SUu6LokpQSCJ0tYe5bj9O0\\\\\\\\\\\\\\\/FNVlN50bQ4y8uv9DG04pgf3a4mWFKUrWSDnoxlmnW+7ffHwHiDZydmeEsAQlCTlR5QExSw9YhHTRQ5qcdNN1KCq4s5oqysjGPQDQUzABdfQnL222KEWEskySekHDzk2EtWRS52X2h0tfwHmwZAnKiZJQOGabPTvcgLbT4FB6\\\\\\\\\\\\\\\/KKL3wTHAA3m9U32y5GvKqCpEhCsMKpiyoUZ5lACps\\\\\\\\\\\\\\\/qw2JIuD22zMJ2sW8AfYiclIw3MAL+Ril4jqtJ1XwyTxBjxYelVBpNQWtf7J8R6YkvFiXDDwQL5q9u7yB6I9ZLqUc5MPQAmH4uGrP5qaoJa9h2LRqEAEhjbbOq7\\\\\\\\\\\\\\\/dU0NJjTafIPsKE0B\\\\\\\\\\\\\\\/DmsaejaKumJ3fPFYZt\\\\\\\\\\\\\\\/6VRPJUfNJ4SULSkoHkXD7TuUOhmgAArwIUFqjWmwdIJMMPiVTl1Xv3vZN7pU2AVBc3Gw73nZZ30TR6nQiF9MiL8VfheP4nqGu4hoz34+hVKjo3V\\\\\\\\\\\\\\\/216qCOfSeyRGCcuKWORN4JAAkB27v2ojSLwVovHZzOwG8IK6pfipA6sIDxH\\\\\\\\\\\\\\\/iJiSTMYW1Cefbw33f7QWC+UQSJywvrnei1GwzmpipSa5CxQkgI0Mt9KDBHIFTWGDOinKdaqOZRFJvx+AZbHObaAmlYr92braftySKSoJG3V+C9WvbJPROrJkpijdaF2UA4ZjwHVt+qRORq6IF7oi7dy3qUJXZ6faOnX4fqJHajJPWv1HIpHPXyL59RJNDFWD61lASOXRy06V\\\\\\\\\\\\\\\/HBsyLQof\\\\\\\\\\\\\\\/IY0TNo7KRJFGIuyfo49m1fOORbgYEYLwWv4NrBll\\\\\\\\\\\\\\\/ruzs3Gqm7\\\\\\\\\\\\\\\/EsfMAbIDhyraDKSVOmk8JsEY2N2PrJrC8ABXo5jtAU+qBkFPGGVq8ltn0MWBzEEAunUVPnMUbvcecKiv5y4x6ckykpKs+2SQ11S2mOz2sY49vzkABCgCVxaIFThB63wWql5gtq\\\\\\\\\\\\\\\/v4g8rKRTgqzpvQjU9ptjw65z9yL0hdNUBuUIYs7wShdeOi\\\\\\\\\\\\\\\/RveI8T3Eqx0op5UFP9tNaWl3pZW0Hzbn77IDgi8U6sQwIgbhXIBbSFDlJ0VFYVUuQrwh3jPk6\\\\\\\\\\\\\\\/n3dcxmYbmnX4+tQCgfFhryehM4GznX\\\\\\\\\\\\\\\/vGl1TONay3ZYpkUBqmFGesN5nLFNgeK2RwrLvpngpXcdNNIypwo2+XhouXwkNxHMSbxbdl+RUatiGLurzXfeFrZRkwRb7Y2ja4Mds211NG7o9+5NSz1r8ygii8fHC5uSURlX3oJfo+G64aERDBVA4bB0H6dpoWd3m0h\\\\\\\\\\\\\\\/5cbAa5FiovwTsaCWTuI2rqkTo\\\\\\\\\\\\\\\/33InEni4vzqipFLh3z0MSoeQYrrm93Y6791QAkkJpvNjjktm42Dx6TvUVmJpkOZsA608\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/WMXN7jxN70WwUGLGezv7iC29XwNxloFVzMFU3SHZ8+ENsYeIoAqpZwpEnl\\\\\\\\\\\\\\\/dsFQkqVPCgD9Vtmde226jo4y+buNbaTb3zIFQWc8AfFfKL1F2xc4K7\\\\\\\\\\\\\\\/aernHoRM3TPJ2kH\\\\\\\\\\\\\\\/HvfF2HK+5EjiAGKRgGIIwegR+Sj5I6B0qU5y7\\\\\\\\\\\\\\\/4ugNaQ0YtwJAtQoxfIi\\\\\\\\\\\\\\\/UCGEttKKsrjAftUm7pHLskJkvtH3uIOopp4OUVUTmX8zcTKRmeeL3idaBoc40Bm1Z6NSIQWRsYBKdFc4lGNAMtH\\\\\\\\\\\\\\\/a1o3w18u4LAPeC7IWCL6tafK27aAX2CSEQPadx5pTeSsb8trjUrrXbZJ9sLHU3Yn8HejtDU9SAmVt05fR7MiUpKPX1CBROjHuuF9lTg4NMB1V7MtsfcPcXzKipAqWIY9zLIezaPQGv\\\\\\\\\\\\\\\/MAcEzy8g+rlBfNiaP9vbUNksgukV6WzDpK63M3kuS9ys4gC95uNnPXK73a9GsHksbJMxSAuOIo7WvpWAYTEvNGn9ClayfLI7qSQXnffb1nnMQbWA7duvLtNsl+rn7bj+\\\\\\\\\\\\\\\/d+3Tl9U2ZF97GA\\\\\\\\\\\\\\\/ep3CqiDBzEgdX8T5SDe6rvo4GJr6Ni\\\\\\\\\\\\\\\/oKSN+GQTE+AYtCxDBwEmAo0faFGwRcVMcZx+ycxdjt9G1lLL+Yps79ejG2j7GMywDZ8I6DVTwcZdHEqQzxjwjC\\\\\\\\\\\\\\\/omTrHvePriM1w1RL56YdIAfH6Kn8h2wHXHRj3B2NuZ8T8w1C36ON6VvdGpTib+HyBvhOFYIzfyd0\\\\\\\\\\\\\\\/BCQYun9BWJIe4e40dI\\\\\\\\\\\\\\\/Pbf0kmwz+Bmq7Wa8e6kT1Va+rkz5DFFdh\\\\\\\\\\\\\\\/aSUIbvY7nlucDMUlacMmMLjbvuq6iwNvhv8SERJ3oJniGxJia1XuatEU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229Z+WbTRzbhPKtk+0BInphw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d2ed6852fe235d714a826fce10954091be551053827ed7c8c9ee4eee8a930d54\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/44.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/44.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/1\\\/44\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0085-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0085-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0085-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}