{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229E13yIhVjl1Axz1R8DTjDl3mtfDBh3aL\\\\\\\\\\\\\\\/WumXIHbGtqYtSx6YRvq9kkv96xpwxxcCdoEeQiFiLz2fD+Eiyk+NWTlFXrPylM8Z1LGlFOs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/BaQG\\\\\\\\\\\\\\\/rUoQKwe91a7m2af1NezcDVyTfva5vm7piYskbQPEJZLpE1mwq2cfR1GE7tXkfEQiuFZUn+pVJjbY7f0ZJwegR5v0Hr07vF7A97jOtAmOOhTZWWxrQN98wVJuvk0bmBJ4d47pLfAKFXZnGafMP2aXJSTe3NaLMw4n+kw6xnqbJdMSEWawlhJiRfsA\\\\\\\\\\\\\\\/CIpFCb+ocm+aPMzZE3P83l\\\\\\\\\\\\\\\/1DQuYWty6L3kVUfdn+MgmphCrMuCXBN7b6s75KdjbQtmVB\\\\\\\\\\\\\\\/ueImD3NKhr5nlXqlSlbWyqsSp8pmeR2mF7G2lIh8tPdrEcKEzfVkdXnBWe9dKM3xTFkF1xsIpNIE42DjDcxYOBRZshvJJ5lt6FWFvEySO0Rh9zkEFWQbbUuLtRKafkY6Rv8YEA9xi5PSSypLJeBHbqvRzXO3\\\\\\\\\\\\\\\/ND7aaQUnItSOEcoZndTo8fTKLD7VBr\\\\\\\\\\\\\\\/2P3mxs2p43BMULFAG0+yB\\\\\\\\\\\\\\\/z6NiW\\\\\\\\\\\\\\\/7JTgMdBSG831+52sprtizFk4ULCX3pWJYkRHfQw9QtPzqbl\\\\\\\\\\\\\\\/mkxd5rJh9LvxvtJcedagR6CaOgKDwu\\\\\\\\\\\\\\\/QE1beTxcAzTHsPXNqT4z238WTqQqx1nZhixz6nifqFZjXHRABk9yQ2oxiKkfPTEa\\\\\\\\\\\\\\\/DSNa18ZvNnIOXdHOfHxzii89c+igi3D+Ig+2OZ13XyE7JCuO3NR6ng1Vd3zjiw+D4shasjmL3VjQhE79LILNVEKEbknlDXkz7pXAtXWG\\\\\\\\\\\\\\\/YdzmdbTOQG\\\\\\\\\\\\\\\/0qfb0lxGmZu5LvZ4y3sW815GVyy3dGUOcPOfbhs3GesO9L6qTRyv4N1p8YNgNzHwmo2HEjjDTzBVu8tpBZA5PqKOK1V2V1syexUvRZ\\\\\\\\\\\\\\\/jv6HKc2LFs3aVxwCqAIPNdKAXFDR0syEfLGklIuoXBvb710IW+Qm7qgvqO9w2QeACiB+xz5DefFgbd22dAohrrm0SyqccdMSVpKdzlPh\\\\\\\\\\\\\\\/qucG+27gQjGlY0zYfbWWcHnnB+5QNzyyXPhkCwq8IrHY7S3+CZJ\\\\\\\\\\\\\\\/CZe6T\\\\\\\\\\\\\\\/1cIueln2sJHtph6X+0Tn++IQM2ajBM\\\\\\\\\\\\\\\/5n4H+dt71oqBtrmXnSddgDW8Pq2Avr6ZvdWozaT+ZIC6LUk6AdbKKYS2lTpLIA4FlXWFuqFk15r1r1lP1ILGOzq0nsjH1xsqMUuibzPi9WSjShhlWkSQZ2nMGIPc+J8yNhn1GOZP8RO3HL+V0Jkx3uEOoGSvqh4Vp5E\\\\\\\\\\\\\\\/vGv92tJnp96ckX8cKG8FpraeRXcAng0oBxDLRCyysJZl+k9z+gZA8lrAn5593isnXH923L7aW4qJVF\\\\\\\\\\\\\\\/AJ1DpfeNM54Do872bUCtMpAfDs+H4MOjKuXSuKHYXZPD0IKrDMgOkhD+WLf0pseHa4KsxnGay9uY+t82nrRwLVCU\\\\\\\\\\\\\\\/p8DOqHtHhbPQ0uinNFcIgNxS14CSXT7\\\\\\\\\\\\\\\/7r2Kv0NwsAB2ESOPzHhS1x\\\\\\\\\\\\\\\/eWmsCsQ+O2rRftLt7335fZ+t5II+VwQqXil4mBBQGy5wnt8Ds5fkU8Z\\\\\\\\\\\\\\\/f+Ge6Pn6V93AazPJ1z1l53qJ8FDdlMIQBhqNlzkCytZv2\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/y1Glqs+3+jsN2GOBMEFHF4kcz+D3R6wuOPu76cQgH2LAJ79WfwUtud3Kxutg4OWtRLwouSZyFFmmmMDriQRboBjV+2XVnBnVqN7\\\\\\\\\\\\\\\/rOxWbRspxqunsJEYma1QOhwz12xrS8mf9IL3efyWx4FFq1UVjzXpJ6nka6ed7BaCYJV2KMizTtJRKPUx1trQt0UxmazBQZqmUd+FqPVUYD+SOPVo2NUs6ywiP0VEn7OVZPngzac58+Z92fnDeYT+DXQtN\\\\\\\\\\\\\\\/NIqMqi5vFw77+Ez6lRg1y3+UtUHi9RjxhYx0CB7RlB4i4RJDMKgwQozXFaat2jrPc7aKS+sIc\\\\\\\\\\\\\\\/AYhG2tpVOguq9dIlACtkDYkJULhY95CdC2D8yauaOzYISlk4UWEBHzy9h4vnBDNQcaf\\\\\\\\\\\\\\\/Pdfxm65ZDK7Yj9hMkP+pUORucf3bDL9gLJ6\\\\\\\\\\\\\\\/1Jx9F5zwJOIQFILOfSFxluoJIPiaJJaO1G8Oqfg1W8ZsDAYcPb34ezHkm80z15xXc2uRpUXBbvCYWA4UQLBjrJiom14baWpsj9ui97\\\\\\\\\\\\\\\/VgT25KarWSEDQCG4YXhcQv9SBnScL3iBOi8X1QgjuhAkDcYDpt1s1CtWdSLdH0nhUHFygeUQzyuysnd\\\\\\\\\\\\\\\/hhoZrUDdHdEOxxGbxcLPSSQG2MBQnV5akyITNvGTIvqt\\\\\\\\\\\\\\\/P5qVI+qv1BdTivHJc6KRJ2j9VAnpNVIso0sH0kuZf3nlaeGINEXcR9xWwMfPIfm6qVWZysHxYi6rmi1j4DtdJEC2asBXdZfxVqqmkF2QS5YRd4VZkr0DryYn\\\\\\\\\\\\\\\/2Uma3utWgRpZp98a3NJgCw9BnkvSyW1VqPq7u6Nrt9sVXGFwZ\\\\\\\\\\\\\\\/roDEWEGaLg59VmvmLrdecT3F7chfU\\\\\\\\\\\\\\\/5TyPBM7PhIXn94z\\\\\\\\\\\\\\\/+te42B6YAn6sPYeTzStQzSaXMPDD0eKfPe4NxfzwB8G8gouqgxD65DtcQwEJJk9dmvcAfORZNCEyYWuK3Ic2ePfapbnKp6hOg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022oRs68E1QN4HOWbs+kyGDkg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220f30774748a3e3e0b2c67ea65d3b2418632d4e0d309a5284f4c450b18fe126a6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/45.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/45.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0090-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0090-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0090-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}