{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Y\\\\\\\\\\\\\\\/DzibSRvRn+avXttGjRt16cBsT2enYrOvatY\\\\\\\\\\\\\\\/N2+GqcSkxtbnNirSRPYlSph0Lq5s7L2hC3\\\\\\\\\\\\\\\/sMy8PjV2QWLtarDLfY96a3RCgNQB\\\\\\\\\\\\\\\/S7ScdeVRWsVDNyH96Wai619suFTaj65Xf\\\\\\\\\\\\\\\/4nJ1Ch1Tz1vETu85vgkY\\\\\\\\\\\\\\\/iycRWqr30ml2GsOoz2gM74KAnNXfOnTdgmlwqCoPdUhiR+rrPQ\\\\\\\\\\\\\\\/dFYAttlHBth+ayhr4xpYUU2lN5K0UA+Q148t+nsoj0ZkZw5Gtau2H3ERvWT2mQbkxno8fLBTf71C8SasC6iJ2e3D\\\\\\\\\\\\\\\/Eq9k\\\\\\\\\\\\\\\/2bWFVgktN11r8F2fwX2ML1LR2cxk1xCWeBdhq+rTA+bd3ulruZnfi68r8zxNiP9ohfhvm5kXysagh4aFFddPHz4gFG3JgOsxNChVvXGTq2EVEauWRNUKm9J8wABhf5sDOQBs3ZLuX0IyfuLevXO7f7hfP9RWAqY1WXA22eoRrnIBQJB96ICCVlAXfqzDBpCNMUvrKHRlqCHq\\\\\\\\\\\\\\\/QOB\\\\\\\\\\\\\\\/c\\\\\\\\\\\\\\\/vxojQ9Zy+ko8fEwU5sPMnLdjMFIMHGwTjYGFuQP8SUZJ0Xv35vFvwV43UYNmQmS+iIddq4yAG20L9RNyjidGcReC+bUSEsaNAZuM8oWatbxrHqpizrVF8gd3NfciuKjZlk6Yi7jQZuV8VTrpjy\\\\\\\\\\\\\\\/OSQLsNN4M0XAkKjRa4RRnajXh7Czl8xn4EOP4GYRPOKofAxcI03HSYV88qCwGr1Do3WS3WF2XzDTPrcdEroPUQvUiqRaAsQ6Tbjp+7GYdAgQhBMuRO4b4ugfM0SuCsTBFwVvwHomZO6CONOnWSlki25rTKrp9BNaQnITT4pEpNeyyRDrwZmNb8FfLkt\\\\\\\\\\\\\\\/1X6QTQ1NRBzS645kGBGMwva56BUQsbfCMawljvHNbFyY\\\\\\\\\\\\\\\/oxcg+Kx8p+ftUWB4HkI77k+VLw6ycTnq8C3Ml8yDtqIdDmrAAku7Rjg1UjNMS7JVzqlKqYO1+V0CU2lVgie4BY5ky8SXEjiojkLWnP+BFVMGc8P6YRqAbobTPmzmw+KRCCnqv3hLDZdZFNeXBVeP+LVd7nNzqynnGACkiBWolfHKKFn5peI7WXChTQx2Cxocu1BmpW23HpnpRGYnLS4QQ2tpDIuKM8sg\\\\\\\\\\\\\\\/3StsiwxtddRSYelFlswibj8mV\\\\\\\\\\\\\\\/yaIlr6Exmhro3RdYf\\\\\\\\\\\\\\\/kqYeXO5VOUX0685vN8KUpD2NxunpzItD1OXYtmFy523u4XohVF3EFNpqpTuHahv\\\\\\\\\\\\\\\/LrQ2YFZp17zIDu1SSFLTClVor\\\\\\\\\\\\\\\/pzCrJEI0fHdVkBtXvTw4JTxao0Kd6yNjhjcNRhUutREzg5ec+lkAWt3Zx4NcnzjltvVyrKIxyC0XTMbfw6u4C67G2VCKncRIfJLhlA7tU8IFL2E6v1hXNJRWJy4DVAmp5WsMVvLkLNw1abpGMBqb5X9UcTD38AAc45y5bI3nv6mnysXSfOS55aLA+11mser\\\\\\\\\\\\\\\/UJy0eOsQm3Fxd7iHLoTmp8lwUk4DTKlqKumvwZm6MJOUYoQswXvlkphzQVdxJZlW0DsXIWgOmeWKgJ4aXuaGAASd70MxbHfYZBUx3vUHYgdxKhqhif\\\\\\\\\\\\\\\/QoTVeQ3psF3cpX7T2uDT4OCgK8np5WRPIgefSr\\\\\\\\\\\\\\\/52nZBL7KzS0zQMKQEBgNYY6WoYJ7lDgHEhfvibcmvZLv9bGvExF1vj324VcBh6xCGB7L73ipuq26myCqZ1VlvZzEB8ntpZIMUU9lVA3oZKVft84slj9epvsZPS2of5VDSL4vAtGno8IJ\\\\\\\\\\\\\\\/qLr\\\\\\\\\\\\\\\/6pa12SCkx674HzOaTij7aIK+88eDLMJygmr1JnKhzhl7GKoQyi9OWAy6LJTfCkCdBHiqX28f3nOBFsunkWqnVT6XfY+R5h\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/L6J\\\\\\\\\\\\\\\/zb31hn1NJ79bsAPGBF9WoyHv2E9saIbXtEjCAFIdPVLdTg4yD8b2tHpt65jIT5bpgYG+YcHR6FnceILl2RjmrT4NSCEWcNrnivCnwM4mZC2a55Dq1lJQ2Q1tibnDTXZMNwcnZ\\\\\\\\\\\\\\\/vQotR0fc95G9qFCZgS2QoY+\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/NaDRa8A84WWQ5AgzPfYrwFebxEes6x3FZc5zlKubDhPPqXqYEGzWL+lcY\\\\\\\\\\\\\\\/LnnFczsnwAiVsyVS3jl8NBYmMnRDrmmx98nrRbDc8+YdHmlkdGmO9WFLPw\\\\\\\\\\\\\\\/mb6vd\\\\\\\\\\\\\\\/KEGy6Mv3UpA3NAA470Bcc2cE1Ix+nIBuiF30VV2nVTCptVWP3s3ShrUbZ9TcQFIsrC3q13CD3Z+hBTnhVEuXJDjn6hLSSuu2hyHAJsBOFIwkTH7IdOHjdeUV227eEEYvGxFCP6jrpCz\\\\\\\\\\\\\\\/GAAyW\\\\\\\\\\\\\\\/1dTEiV5dfcdtG\\\\\\\\\\\\\\\/U\\\\\\\\\\\\\\\/h2ItcR+yTKpH1si2UbOm6Cbq4kLnQ6+JHpkUNjnzMgJ64YCUBmHO1HIApEFtjWl0OFWJnJ6B1qPgeqv8r437qBXDPAiyJdZGYSKaZNn\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/QqVSDD\\\\\\\\\\\\\\\/NMF5cxhQ2082ZSpe0lURMWU2uG6zn41Rw7y9KoBMUMWPEnNZ96tSB6o1rfxPVpBfMy2r8eP\\\\\\\\\\\\\\\/VlcUEPK0btVNzm5kXbV7kLBSKdC\\\\\\\\\\\\\\\/7PvcOl16Mzn92rTa2pq\\\\\\\\\\\\\\\/SEwWUjUxraR31n5PIewg5leP9\\\\\\\\\\\\\\\/oXCMkeAikcuNg+id7h1SKSAMifQB6VNNEj0GJqtTscnHCZnPX4R00HEjE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223VzefH\\\\\\\\\\\\\\\/U9HJbQpXagrpKAQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022099516324769753be3519bdff54d6e7622869b99fce53a86d340c702b710445a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_1\\\/P4.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_1\\\/P4.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_1\\\/P4\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S1-P4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S1-P4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S1-P4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}