{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jQmI9AAyU59V\\\\\\\\\\\\\\\/g7G8Z\\\\\\\\\\\\\\\/DJzIrlb8kuANkgdKBIvu10OJK4Fu\\\\\\\\\\\\\\\/eW7A97mxEDkABPYqbt5IxwhoqfXNTJlbNOqwYauMHzMRNsbzwILPCEqWQ1xNPtLiy4GSJ0cU9MPVzQlV9CoqT6qv3wKnBXBi9CzJVYy7vNtdo\\\\\\\\\\\\\\\/lmfcfBmDCkf\\\\\\\\\\\\\\\/zMUz7MgDHg+feCtYewUH0IZDiS\\\\\\\\\\\\\\\/5F8Z0qgAVKFmEUJTo4ij+pkanAUTNHXajC7ggsGVwAdkvWlzPiw5xAQP3OOijA9y4MY4bgah0kO03CVo7L8+Dr9WlLVtSCZUeqcubZc+gK6Qp+aYqVXyjH+1w0Stq+CzkrAXmlbvlzs0Gq1oGTUS8D5h78I8fuO8BB7DIpFozU439AleHpmWoEjyDEKNMzcefO1e1Kg17SJMD7K+\\\\\\\\\\\\\\\/I89fWi+ux4wTC9MUNoqFdmNIdH2DadC+oagkHCOAYM70yCLUi1092\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/ME4hYZT0L8vp36Gbe7kVSfJiHGfJMMatOg54fYZFNHinszMC7PpjEE1sHIaIZJJ\\\\\\\\\\\\\\\/caVJ7gwF6wV1PMI7hDWCYt8TpDxI3JLY\\\\\\\\\\\\\\\/hO768aE0YwR2fZ0vh0exUuvq8\\\\\\\\\\\\\\\/QJDLa97C1PMQPm45qNVw4CQ0LEIanNFCn3Gcrz4LnGiltM9y1Wm0loNBpA8NlmqyjwmxmhJlUoQnkvSF5Hx\\\\\\\\\\\\\\\/bodbOhQ8eduZnzEum9aguA+H\\\\\\\\\\\\\\\/U54EWCgOLLuyCLQc8NhvipfdpTk7GneiL8h\\\\\\\\\\\\\\\/VwT798Qw0EmbSD\\\\\\\\\\\\\\\/vzE0lAyB6SbflnwOfnlUkXuAX+bdonJuZ6zjsNOoRCga0fgo0IUDpitPbOsF2CQWGFYG7gZMAT6oK8swauQYaq94\\\\\\\\\\\\\\\/KtSOdywzEN5\\\\\\\\\\\\\\\/vw1OTG8IgA+nZ0DW02\\\\\\\\\\\\\\\/Y7kKgDTf\\\\\\\\\\\\\\\/uqQDt3dDQeDUw\\\\\\\\\\\\\\\/owZ9P6oLXSgiNn842+AOD2EyzZQOHAGnDmzRmTrYbI6FOPHxkiB7QwzMdO9b1q+VAE6Q4YSsoahlSfTyorFI73wM+tnDJZqqeuRwl2Il7+GZuMxiTlCsP61EkzG6jxfy4pUko90x2SjT6tyaAgJQZSPagR3Ru7kpIFfwi\\\\\\\\\\\\\\\/x+3pzZwO5z7jY5IJ+7BpoV7OURG4VZCcsQDXl154IceD\\\\\\\\\\\\\\\/qceCqaQ28K5rQ1NQxNXBBb5PSyu0yD2GCd5t8wS0Sxg8XHOC0ufYBRGd1KHZPD43aZGmTT4+hFktK77pPw56vhqYw1Pfj4iuGRu9j58VEQYjvzofHpDNqjsv3+m3Xa25\\\\\\\\\\\\\\\/YoDjY4c9dAcXRr8i02fLUNGf7Qtgu8E3Uurt4y3tkJjmyaQ5SHHoPiQ7rpMXrYXoyZ2aw\\\\\\\\\\\\\\\/0+SWNDT\\\\\\\\\\\\\\\/Do7PWM5RK6AmgaXcQiwWGMWN3zx8Ksfh9wE\\\\\\\\\\\\\\\/QJSekpZxKVXXalbryqrVJOT47j29djInLHX1337BfQmAzUqJZHT9W7qosd8+naFH+H5hmGdaKXVZH8rOYMJOEqgsMssR53oIsTjdI6DdXrqH5AYLwH6mq9DyHM47iBmm4LoaPfcltb9F14F51x8Kn+2TW4zB7iHiH2+4XJR1QXwZXrMjLvqxclbGT4mBoRw1zm0zvmuTZiMy4a2W761Q53+spYSutJvgtlzO8bQzcTzoWaPH+fUHhhXGmE\\\\\\\\\\\\\\\/HE1fd+c+y+QLsJkc6pD94EiaY5CQPcKdKtE4R\\\\\\\\\\\\\\\/wzni3+Vrf5GQe\\\\\\\\\\\\\\\/oNN5\\\\\\\\\\\\\\\/gnhV8sDXWsRLxz5S0DMS9KiHl3mU4\\\\\\\\\\\\\\\/NC7hBDeV54Qw4LOnPZPuhV8N2l2BFT+bcFX1gq1MTgGDqeP1UtWG9lFqlNNHXYReaPlhkvaY7+Eu0+FxNR6fmH8nFEkEC6E\\\\\\\\\\\\\\\/xViI2hSRTICnuF034WtjXMZYtczSL6L3zr+aVXSrYg3FVRLc3HI2QioU+ZPY072N5RESCdYA2iYF829kJcLndiTg0VRRDhBWOMgjwDNLZkLpiRgZfoZmv5TRu3+uZL9RfLhwUeyX0HBdL2\\\\\\\\\\\\\\\/OcfVQ5RMHPg+ry6JHOksqhY4onJIdYiGR\\\\\\\\\\\\\\\/nnOlnNJnvTbHtuUwlFelfmvxIVSlJeXjmjGg+yEkWWqpn2SbiRg4Qupt0x4yiXvdTzILLCliTqejf7yQsxTMJevux352S2P1c6Mze8qcrZzlnvRgRQ8R7qs6FozmpKtZNxZDiNMOqc9pRgRSpbiiglOz+gwx+KLukHd01qsIcObTrSAx0dX4r0cwDcF8lqEbNA5eOkeB74LjpxbDG0X6NHvzl9f17ITQDMty2Uo5JkzYzqh09LbHdvVn2NKA73WNGmQMeeXKC5IVkVhWv4xZzYH+OI2GmV\\\\\\\\\\\\\\\/wXCeNKbpWtgGG0FRYaXZXE1ExmZowejpk49irjZXQuDRdlx3taZV2COTGVaIEPfnkU63K3NAs\\\\\\\\\\\\\\\/LSLmZoPsxj++gvTRB9indRicS1We+cfifHueP7IBtDsBrp5F6WP9XmUAC1VtP6JLy1uzP\\\\\\\\\\\\\\\/bQIuywW7VfN3YVcB4XxUHtFYLBvYnQ+Yvks1N4b24AyW77SVi8mGaApWRpZQpz139SaWYO8nEhNRUobFPK2c9xXOO8rJDmccTJGEwPVWtWwaYwS+SPsYfuhdT4urlhd0lhiYYtGKhw\\\\\\\\\\\\\\\/nPevC6ShU\\\\\\\\\\\\\\\/w65fHaPZHzAZDkgwRw\\\\\\\\\\\\\\\/iBw4+nR5JQQrlcqUA\\\\\\\\\\\\\\\/Y3utTNrgRPcy2eU7mw5EZx9tbLfHImirA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022s\\\\\\\\\\\\\\\/2Q\\\\\\\\\\\\\\\/3tKRKGHlaa8woVfpQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022363fbaa3bbe27fb0eeb285aedf0964c7c030ee4d86f43442c53f8b07ac803a16\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/2\\\/e006464.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/2\\\/e006464.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006464\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006464\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006464\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}