{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iFlk5ilkIgDWoVQE8gnWj4\\\\\\\\\\\\\\\/4cTKtCeV+XoZtwhVdteMmwLaoOi4pC7hKbFYV3+HoCIqlZ0BwLkvqUW6gIYZrmYNqI1dV\\\\\\\\\\\\\\\/qxHp9aiyJmRoK8qp8XrqkX2UVIFCPhTcOFmAMZiEZDks2ipH95vSyd+30hOgKP8b+fiVQULp2exkEjRpJTU0ZzHKrr\\\\\\\\\\\\\\\/Kj+zHpdL\\\\\\\\\\\\\\\/b2mNXTlU+g7tXOEO4XR9SuevysVwFLG2nhP+VnFBR4KELZpOg0GTkYdcIDwS5D\\\\\\\\\\\\\\\/CzciT1ThwjnM3M1jIH21M3SDsmUQU+492htRVA3JYAfGjO+lj13T3KpKBn4JVo2jpc\\\\\\\\\\\\\\\/VAUAzllIY7GTfRCtzDuQhULEhWr28PoYAF\\\\\\\\\\\\\\\/kiucAaueGiQ9vBO6Tfx+VVOk4bI8yQLqf7+Ju98y67tiUG66Bpw1WSJNnkLiJDVhwGk5hzf9lqzIvUwp2xpTb+54IYphIgqFYh6EBr5d5lsDnPOwEPJawAJ83J3U1MUQwIWAOd\\\\\\\\\\\\\\\/2ajYD6kM8M9eALrp7CZ1Uc9LEb8ROUyF2\\\\\\\\\\\\\\\/kQPiBZSVV4w4+1wfDogrr22pVnHs1LlxaELCnAwdWHL\\\\\\\\\\\\\\\/pxRbojcQzNsvV2BJkGJbVVgq1nNJt5MJDJP53WbXE8h8s5wkCF9SngRcn5ixb2Kgx2CfdCnFAVY8OvF8vZeyB9N\\\\\\\\\\\\\\\/1vH92oP00y6Y23cjOOeFB8zxEDzwjDG8u407RXhSKetYGme1Gb0ZssfKElhjSmdNWGAu\\\\\\\\\\\\\\\/pMz5fG\\\\\\\\\\\\\\\/F3sTtoDURlGeGhZdNQyPPoMTc65MSW0M0IqoYjVNywv7aEl5BLefG\\\\\\\\\\\\\\\/HouAdv8d1dNOfuj9Gn+nQSJff\\\\\\\\\\\\\\\/iWy7ju5mUPW7SuuVRjR8Aqat5TDvBllpaiMZ\\\\\\\\\\\\\\\/Ekn8cM0rfh5jb+Y51\\\\\\\\\\\\\\\/r4pxbQS3Q+JA0pYMFpcecYHAVj5aTFdWRUJdiAQQWxJJpwWLjZjTlhD7KNpVMQq4lWNdSvEDTCAz\\\\\\\\\\\\\\\/xi1+MLxNMuUMgoCgfsnfodCpsQAGmQuYn7oLptvvJBv8LEL7q5w0wiy+4YayN2eCl3wXED18p9H812aQ41kEnWtjXabD9w+SK3zSUzWxoV+skUdv6ySCeALu7QmJVY+lmyBhXPmavgGyzJjoMIGa23WHSv1HVNYlqM24d2XqXkh1izt+hq9rUXp5QE4Gquj7NqFiV4rYurIi7KweglNEIMg1NPG8kqn4DahqRXuYhqIhFGyeEbPpGeer3H7Qt9p3dOWJLmjJmqRBk5jDl\\\\\\\\\\\\\\\/6zku4o5lK5x34sIhuCzgA6PLXdgxDB4Bo\\\\\\\\\\\\\\\/wHBxwok\\\\\\\\\\\\\\\/Wx8rkOjHsmuwz0hugyRS1xcWJX+BqPPjhO8yMnwo29Y5KDYx0GdgUxyvVpnPdBiWue8tvkT72zC4T6qACOqQ0BwIP5i1Z11PPJRssx5ZMaCAmPicKEy+5MzknWyQNvZfDOtbB\\\\\\\\\\\\\\\/04+RbTExuEoV0F9TfxX0WKeAizRdvyA6D9h\\\\\\\\\\\\\\\/B4hJeDlNJ78RjdCpzOl1gG0NgilaoJJId9yUNO7jnkM3gcqki8hbKr1nbuXl1qWNik3KJ\\\\\\\\\\\\\\\/QZNmxL5b5uopzZv\\\\\\\\\\\\\\\/GCYlizAOQeyucQrEP+JaOiJGaCF6ssADvk8eUzSLQwLNikoi3uKg45xfT9fbPdTZnN6ifFmqDh62T3bF4+3yDOppIJaRpLTv2s9a3Z8kK3vzPSXoLDgsCJFgEfGB1Y0Mf+aqIDEuPr6nNxGk9sBxLA2o+9IoMEoDPv9rPgngNxbdlUXK5QZwY4nP5YHEx7VoJOIbQ\\\\\\\\\\\\\\\/mnBmYLcsX\\\\\\\\\\\\\\\/+uxob+aIsLyafY7i55\\\\\\\\\\\\\\\/7OFnPS9qAZ2lQg1biGPCbKRdAAcCUJW9pRispI76MEu\\\\\\\\\\\\\\\/HiIIW5jwqPT8G\\\\\\\\\\\\\\\/l6tBsmjGztDUbZkyyV3sZYHb2PVOe2+Lz3PQhjlxQOfdxoSAys32mYEqJywhbOZJjGvgaejiaGIHSFMNYD26wVPbToVujXekTfPAqVK43mjtZ5wiyIJ+1j1Fwe7fgprHTb1DZMA7V1pMudgA9vyXCKLLK5x\\\\\\\\\\\\\\\/7q6ZXekWeKSIH8oRMAzOI041INxm3XXgvnMWoNI55fYCNRL4D7v2RAP2GRMlHnjo6vtRAnTxZuz\\\\\\\\\\\\\\\/egXta8L8OUw5\\\\\\\\\\\\\\\/GynVljXbn\\\\\\\\\\\\\\\/ORKPreK+EDwArRLh43FYz9McnW4wNJQ3nPCk8YQXyzieZIXaJuFwVUzdfA5MkZjv7EasjmifRCZLAaZL4vi8DdBJgKg7uL8yuJPP\\\\\\\\\\\\\\\/osnwWS5D24DzU9sNZuEAhOVVAnAYHkGZkKNbbNQLEbUNFCEZL9\\\\\\\\\\\\\\\/wxeVyLGFWLAc5H9fNCH8lB0UjfeVGjleuII4mVJWYA5XxBftM93yqxDIlzRPmRzie8LtlUTCon\\\\\\\\\\\\\\\/XOUP5dIQnf9n3CQXViwIevPLP0PpSxo2wVZgG8rlwAsMzFLtPS87RlvZ3Kdtu\\\\\\\\\\\\\\\/x4oRHHAiE+g3QLO1s8sbX83wHf0hou0JQesj99hnnT70t\\\\\\\\\\\\\\\/cfnyY7j2J3QeP5cK9eBdeL6ZSRFjzDa3MeERH0e2rUrxPq94Blei58fszYNc5TUogG9Y1\\\\\\\\\\\\\\\/G9himYJk0kkVxfdg0yXDKbTeOnZVDJowTGJKCwpJQF0Aj3AfIo\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/otm8PBEtWKsqoa5X3LxY6uexZbfgQQFK7zm9wC5C5E9\\\\\\\\\\\\\\\/PEOIIStWE+xedaCKiN7E72\\\\\\\\\\\\\\\/4ZmqARSWNes1ioH2rIU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/hAPz6fo\\\\\\\\\\\\\\\/0iokS1ffe7Wig==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b67c8db73023b45cb8dd366a4f6efe05d5aa9908806382d1cf2318d71c1c3398\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/21.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/21.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0067-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0067-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0067-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}