{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HkgSrabkNvX7h0KnzNXVJXG76BpWuiLNNRWMQaD9kMNSQozE2vQJMg\\\\\\\\\\\\\\\/8UEuBUWD528DACmJaeg8d8L8+teIQE2nCP13CITaIH8tcyBukAbLjBXWVKL4KCa1TJOWyry8sIB9ipwsgdiHZiX0kMLjZN7E1y0rjLeUdU28MMnxurx42G5TQhvcVBPQlToQSGCRbHpIxGNxTcmCuZk6xE3QCDyA+thyimSOJ7qsmXeWTnNo+P+Nj\\\\\\\\\\\\\\\/nxU8IYi\\\\\\\\\\\\\\\/aaPe2WDDwPGqE6RqNX5rHyGbSz6nuYAyXF8J2aOKgfEtJCGYci9KN0hpN+kW7LBRL8nmVvZ7sRthFiOToc+f2Q3kMcgGg39z7Z9ZrXsM18b5uJeupDfK7TS1RwPFxmR+j33nWyRhJCSyWeqpg209t1UQnbEnc5bX5ss3kNkaz6nv9lZEcFWyElVL5KdFx\\\\\\\\\\\\\\\/JoFS3YaE+EfANilD3BTe74rhmvjMgfL9uIYS+s7NS5WnAqa0KLxhmnPpuk8fTtMWF9MoA+RoWe\\\\\\\\\\\\\\\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\\\\\\\\\\\\\\\/kFjfxktuMRVJ+2QlNmdtyiZ5NTGRXURhyHDBofr+NAG+XVOTnc0Bx8Y1Xifo3iXQUWHzHduzphaebTsZr+rzy6Hnf8vku7X8dYAGPtyxkR8EMbO56xUOP3YCkH82MewgCqAtmqnw\\\\\\\\\\\\\\\/BS6hypiKKanoG\\\\\\\\\\\\\\\/iwo81IGdicuBBC1fd708qA8ze1W7gLfTGI9aXMkNhQCFX0QCEe4z0NiChww670xDnOn3fMcJ0fdyt3crsv9wMwT6JkgpcE5WjdUGaKrlRk6u\\\\\\\\\\\\\\\/PBH2ILoO5UF\\\\\\\\\\\\\\\/Ez7vQE3RiiQu6tb\\\\\\\\\\\\\\\/I\\\\\\\\\\\\\\\/PHgfYgiOc\\\\\\\\\\\\\\\/zmBI+zlV5RW\\\\\\\\\\\\\\\/nkp41de0Cf+\\\\\\\\\\\\\\\/R1gVIseu+mL+H9mGFeI4d1A0C2qOq6akShupoXminwfDbqFFMSVHVJ1X5aGpQOqRSdE8CPvpf4RedrYWD0VDfxWKp6IEWDOAtPTNm0HysdAhY8xzNLvw20G6EIyw2Ro7qoAqtLPpHIpBKsh6DEsWKSKRNfZjqko\\\\\\\\\\\\\\\/6zaNqsnmHvhmJjtBZoK5HgwDtdmMS6EpcNrKrbSOJr1i8HvoaxVyOkxRpsnkWbFF7b+0HnZEY02aECscTskPDveQ2MeEqLAlkCgr19YwDJuMG3Jja0QTSy+zaDcR7zVBUmPkx\\\\\\\\\\\\\\\/roQvm1llxg1LC9AnfyxxV5uoHWYz55aOTryEPQuiAXc477cu7l\\\\\\\\\\\\\\\/maMd078\\\\\\\\\\\\\\\/zAxZmBzDcxwlRhP0Z\\\\\\\\\\\\\\\/Zq9+IAdmtC7zDIHvwgmAyWw+mcXii3cFmK8BabK\\\\\\\\\\\\\\\/rvIr\\\\\\\\\\\\\\\/NHTsEn98ERqUJ4+nmXbbJY3\\\\\\\\\\\\\\\/6I6wPhLFdhXFS3ADtExMUvKtDq3Kqbm33G\\\\\\\\\\\\\\\/yebNigj76cNO7FkhS1oR3BGhZwyrwEhSNK28Micst3H17YHdU5LiuYCGzkwD6BVtTC3un6KfGuyVlc1peuvQh5rMAHC+fwVZvYudxxvb1B3\\\\\\\\\\\\\\\/38JfzSyrpAQ13a57R00eniQL5\\\\\\\\\\\\\\\/7qJOwgD+MYFd\\\\\\\\\\\\\\\/8KCBp1ub4RjGIM6njE5N0J7cFuRnN9N88\\\\\\\\\\\\\\\/EH2fdi+OJZtTxMaCsMqTndNumBjAgM43URkRubQEn7mITg6pyA1O+ooHs1V6SpVEt7NIsLaxmy0M70IOdRdIr9mYZREJrNkNLoAci5tQVK7cTi4f3DmBkr5ZPBDcYrP3a96SMfkqGH+PLDgzQOGXfzyskJdBT5nMq+r7373Wzj1yLlW327tF690U0ME695nWS5g1e5EKszeJrRser2c2NC5Ut4m9bnaJu\\\\\\\\\\\\\\\/3TmCKj7CdRtxkf8ZUSOzgcjguaPoBAQhK7BJd3CgCl4cG4W4PjeLNf+QvqznKJRPsdnxQBFN5ydHNy7JQMHPorm\\\\\\\\\\\\\\\/elUBX3Gy2LnXMh5dnyfSfNZXyqI\\\\\\\\\\\\\\\/cX5SjKUbb8ZfYwdni+SbISPbVHoO2GGaaRX4pBoJX3cDD9Bq\\\\\\\\\\\\\\\/0mydV6wfnKEReX6J2GTuXw6QRjn2YGO28NP2gHmCHMzp0L0CFKlp\\\\\\\\\\\\\\\/L8JQjO8RabMUKRYPquAOxpVq8lHnyeWKE1EsYDNiAQ5fz\\\\\\\\\\\\\\\/pdW9osc6FuL\\\\\\\\\\\\\\\/I7lOkrrCGgO\\\\\\\\\\\\\\\/DoSmGm1XEQWTsAIFXLqtaerLrNRdNg4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022YBW4j5UxGBHRfEhJngXjSQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222999d5b5f6214810788fe0402c68cb1d849bbe6fccea5f0db94cd108c6bfda18\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/2\\\/e005837.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/2\\\/e005837.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005837\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005837\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005837\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}