{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022c66gHo0XlQYw3ZWl1hfA5GrYduUeywotTMYwbBgEotjP8kM29lccIYQ8C4WOqoa+hs25ak40R9MxjV5E0AUyrJlbvjMTiq1cGvQ5iFKCWSrJNZbZfj0R88zAQkGN7\\\\\\\\\\\\\\\/1yGjHZbtMOZdswZJpuWHsDQapi3VMHiuqvw7aSfRnfkoV08haLh6NtcVL4kmPPasxqZbhHzkf5f73Fm4c712njDn2Iz8X8sm6+zIKU9laEcocaeszdbSVZZ4uUzXsp8B5WEF5eiw5JLXgReR5GViT\\\\\\\\\\\\\\\/qAE2JviIwtLlh3EzpKLrL2QmtVq8CKfE4x4tUK8V\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/85R0wibfp6B1XWz+R3QVtcpFRt9iRvjelkUFWbgf6XgOs\\\\\\\\\\\\\\\/7A1TDkrkLvtfbQZXFYPK3em2ylvp7A1kUOx8+3xJF49u4CrKW32VdL9R\\\\\\\\\\\\\\\/VU2\\\\\\\\\\\\\\\/4jbp4z\\\\\\\\\\\\\\\/pb1vMD0dGOXQo+940jplj4RPbRcFd2u0zH8MgK8CxRHKxmeSly36YTpPDHVFiBGpcHAjSlv1nY3P12ABitIOeD8qWZhSDQSBT8cfMyOQfiBNx4uo9olOtanp1WWj+JB20F+rNXHAvoVgp3cdPr3mDXKdFjITFV2u5GvCul4rmR4rjAFWrHRTuqiZIb5DyFQQeC92fDkulEzLEtkzmt2fcs3qoygFrO4excJAL1ZW1cEmCy7F153dIFis0u3Dtnx0IhNH9y02SgoH0CdR4kILvGe2ad+4XyrGqFJmeGAFGhWaqgfO\\\\\\\\\\\\\\\/QZCTVjkDvxc5gXbjYtlELiunto55+a5y+ORKr0JQA4gerzujTeWoJNwxNAi93lcFt8TvnDbC+tL+gumAa6J+mIa688zNVWgfD91Ca8MR5kcoIrilociciTe6ggfWjIJf0TnF7xLWJ\\\\\\\\\\\\\\\/cHH1K8\\\\\\\\\\\\\\\/c39kVDcnUUnQ5bYpJGRRf2hynMUjqMA4b+kunrisIhhfNudyc4oqruuyaScyAmvwsIYKLqu7n8BC2AZvBtckp9rlrUnASoRNTwzt9bbppR3jTGi2aF+f4ubyN19iXpMk9wWHuhJM1JD4eRrlOomehfvQwEm\\\\\\\\\\\\\\\/GcLQen8Y7YB4qpvREXVl5ILSqQL21dOW\\\\\\\\\\\\\\\/OsRBeaLHqbTrVeFtt9AMTGCDEBRD8unisE4myNyARE9CoIb9dERq+wIw64SbUEWp2DI6TWPhPguesRHBX6PeNElwmN1lvqrJ5U6vt97BUK+tqfYSQJgUy4OxBb08B8jtCikAjzoG1T19Z8qRxNlDW1dL\\\\\\\\\\\\\\\/oJw6gWtXqwccDa9PwRKEM\\\\\\\\\\\\\\\/6Kzqxy\\\\\\\\\\\\\\\/pw1SGL8Zs2MYZjDN7FE6DeV40lL63dHYqQ+OZgaFSE+a0s7q8N5Lqsr4rusa55rY2\\\\\\\\\\\\\\\/Bfu\\\\\\\\\\\\\\\/KTvjD1QdUPiDW8vdUBdah2Oa+m0yHzqxsMTTXZPmEUxp9OIf9L7\\\\\\\\\\\\\\\/qbV+g5JefqH7UrhO87SnQQTZIde2M8B9MMSoI3wewSazGYwJ7OrLVnedAHU8N4lALDD+cQyxnSWbu3q4PdWL+62cR9FbUqv9l0zwAWur1IXF4OBfJf7pt1U0FLlu+Oe8EZOsTX7beQDlLyHUIecnl8L32srXJifEJ\\\\\\\\\\\\\\\/wcrQ0A3QlVekswrk7pe78wUOMelijiw6sSF3bXh4PMB\\\\\\\\\\\\\\\/0H9PEHdDaZwcLruA2IKrpP9z1gpjWegQx82\\\\\\\\\\\\\\\/DCBxQAkkwgDDcd99WqnUqdmaNqmpYUr752u9K\\\\\\\\\\\\\\\/xuDRqMxTNZzPP85cp4BW2s6n6zcNjuc6ULsmEKkynNi5IRWN+lDnHTrieDM+hOfEljK4cnEj4ryPN+pwXyogr8al5UYVHLkBE4Cy\\\\\\\\\\\\\\\/E0nLRYl7AYrezOND1Nl7wW6GAp7nroCHaWy+G4cZp6rTJC3Y6q7yUYCojFXnC07nQgmt+0sC1BtrTs7jIja2L6fL7RbRyJzB5AomrKgjxqVoIEJ+c3wgyIAI+hdHet9q3vBy56S\\\\\\\\\\\\\\\/cjvzuDkr+yde8vIJjQAgqnhFqOlFlBjUoLaAU4\\\\\\\\\\\\\\\/xYw4ixwmSps7f0Rc\\\\\\\\\\\\\\\/tM0LoKnERb4UoUarma1R975d\\\\\\\\\\\\\\\/78qCO0i7DMK+Q8ttVfX01EDUEfP00ek+0ppf3kLVSEB7qgaDWl8iKdvxXAWJ0lmSu7cDtyyvYyLYUXtR3xBZCy5q46rzBxlO6Fbmtj1GNIc8rhOCzMCS0lM6rEgjMKg158oxhLvZeyzRaMPpNVrLcrSP0VGHSdY6dmX2zlkHLqp+nKKAt\\\\\\\\\\\\\\\/WM9fu3ai3t+A4COJf4ttR3UnzpXITVDc2DsA7gO8HnFUrGON+s5eZhIXgiUkjF49DoxhSeDKB48CAK\\\\\\\\\\\\\\\/CT7XMherrAviuktqJKR19p06lskDUEZ9J+Wr6250oKauECfS6LZREgyW+Y63W4o4buzZJq7byLkbUP6Ey1oV\\\\\\\\\\\\\\\/edeYi3WHOooavm2eTDwn+AUFFYw1qxq3yfLCEmuiRXJL\\\\\\\\\\\\\\\/om14g+xaS3pKQ\\\\\\\\\\\\\\\/OONL3Nm+obYsVQyQj6LyL8EJH+D3ELXAbOHgeWoXgw346CrivXUYWdwjZPqWP02EyZVtjqTwhz0Lc+HNwO36SfZw2hCnQ2xMH5Z1rcSSYbj3qYfMjZGMNZXAzPMPDdHpjNXyxf3rC+KYMNgS0l8B3MPsWk8uT0v8RPBCaoV94CGhxFf4txg5leaESGy+Atx9DvB\\\\\\\\\\\\\\\/B7W3O052WJN+lif4kaE3KTcNVVTLMM3nI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NV\\\\\\\\\\\\\\\/7D292YPo7Be+ueLqXCw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225398c0a3103f16ea0763a2f7981fda982b40b14d4f7ceded92e24db5523e26e3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/2\\\/e005344.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/2\\\/e005344.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005344\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005344\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005344\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}