{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022K1Y1xJ8eUsm8w+3cOuY1kN57yhOXt\\\\\\\\\\\\\\\/9cCHO47IaEmD3XqAmecpFA5aRE9R3rsv\\\\\\\\\\\\\\\/fTT7MY+iy8PucgrzUvH7kk6mZdUrMD\\\\\\\\\\\\\\\/iQtXGJKej4aDyav4j3LB7dHVYwubefGrfn\\\\\\\\\\\\\\\/r4CeCxHxsnmOdZqutc7fbPH7upbzO4HBCc8\\\\\\\\\\\\\\\/sm7q9ISfrccta\\\\\\\\\\\\\\\/QtGDT1p9SxA7HxyMhQFzzrKfJ+AvvlMtOMVUX5STbOVUYjtM92ZS2f4n2jQY3Z57rw1R0PIsKDDsl5hQvC0j+b3lyDOBIYq0wTyKWJqPjbl6CBW\\\\\\\\\\\\\\\/9BKKteTo19UAJJ3lBSRkmOY8johfQsx8uQho7wZ7E6xjbb1Tkzy2jTxlQ7jmb5p1sY6JxmIVZT+E3N6SSUE8QwSz7gQzGn78DUTt\\\\\\\\\\\\\\\/OEPkiBuD+Ei5TsnONwNSNEAjK8l\\\\\\\\\\\\\\\/VpiWknxreUJoHE1+tA+Oc0XWAPgFbeY\\\\\\\\\\\\\\\/Sqtph5YhWZCp7k1beFWOHjUoKnTEa5np0AS\\\\\\\\\\\\\\\/UyetObse0RusKRuwdjKblDIv0psPeuHVgViLKkJf17NNFaX8DUYsKgYDTOohp6qGhzqVltb0WZHn+QgGIJ9FrkDSKUMQG9MKGX6S5oqbkvXj2WUz5TXE5P\\\\\\\\\\\\\\\/04PEg6abyMxeub+sCVODc\\\\\\\\\\\\\\\/03wI0vIhEkav2A04lnlX0luuCskHlOzcZVH+FexBOLcq\\\\\\\\\\\\\\\/BUSbVFw5n0sYUQuZaq7dp6FrkNBq4xADbAGu8jNLMuQhE6Q13dVkvl\\\\\\\\\\\\\\\/Rsoxy4pdbkj+jg\\\\\\\\\\\\\\\/h7QO5t8w6YTatPikLlC9LWi\\\\\\\\\\\\\\\/vQADbDjTudxO8Vil5fo\\\\\\\\\\\\\\\/FD\\\\\\\\\\\\\\\/vxU8uxzF1DznQSrA3thWnE\\\\\\\\\\\\\\\/Iika0haf3kODZQfmSCPivEkv95xOkqbMpSmOg9c6oRAM\\\\\\\\\\\\\\\/moM\\\\\\\\\\\\\\\/aDeHBZBB8AVtS5uCaCtIc581CPfQPdR56FY\\\\\\\\\\\\\\\/Jn2jFK+TXhRAaTxrghTYTP3o7TQtxE6M\\\\\\\\\\\\\\\/zUEPrqR9d1d7Qt5QU3rcswl8buNTIwLnSlJ\\\\\\\\\\\\\\\/nVsJmzMLD2Q+jA+fIoE6Jo39USr2poAe8XPmT3xAqFxzbppzwxn3vrD5yhqdf00IIioxle\\\\\\\\\\\\\\\/CTsMSoTIYhnMHDpCX50i1Y1ak3mFUasJcIIi1bdSa9cKJvNXWVP2FtfkAT1PH455TZHqgslerQjhCGdym46QAtHhb7cFSDUOfiYJTjKhxCwT74yAjNfMaMFPiINvi1Re2VmpJogV+02B8\\\\\\\\\\\\\\\/pwY7sd5YDbueREiR7eHKOmvq+6PQ+5Z42ZduLE0b0sJ33hqM5jlmQmD96aUbOLXHr7BLilb1Q55AGFiMyMrrsdOTWPEZZzFARATJbCu0CWbNxh8T4DA\\\\\\\\\\\\\\\/kJnYTM1mzM0V+0\\\\\\\\\\\\\\\/Y0DSeylG8bS\\\\\\\\\\\\\\\/yPUHd1YD2aOkixA8uRmv+P0q9nyYGL1S\\\\\\\\\\\\\\\/gQPYO+LYCvPqpCheYSidBS0U2b7bzqdAJUv5j\\\\\\\\\\\\\\\/McJXWS5GqUm1fZUCP5mHb2ZV1mMxsArzz7Ot\\\\\\\\\\\\\\\/fPKAABqs2yPmiLzcKZ+F0ykImn7cUPBowWCvDXKbp1Ffuw4y5ZwjhT9R59AC\\\\\\\\\\\\\\\/m+ICNb9sAbwctNrITy+QNCzl3Zh0jX492hJZjlT6bnySKBtu0Er\\\\\\\\\\\\\\\/wWnOKrby7YVH8+h0txifgD46nVHlUliLNogsrNqCQpb+6lusr1VAh9qJYK3QbvvKXzb6pos8eDRvdlMrhHBIUmWFR2acroHFx2O8yaKIvnCDApjiuvA0\\\\\\\\\\\\\\\/Mf57ashVg2A\\\\\\\\\\\\\\\/M\\\\\\\\\\\\\\\/GhsTTe\\\\\\\\\\\\\\\/iNLi\\\\\\\\\\\\\\\/GeN5pYDHXKXenM4ydkefdEmvhvmWDgBeJO1lg\\\\\\\\\\\\\\\/C9HDdV\\\\\\\\\\\\\\\/PBrahG3Nq8nqGJLlkJ2famy6liuLYe6fQkMWfQ3IEfqXObQlHqNl\\\\\\\\\\\\\\\/404tp8MWNdgKaVJYRu2hbstKl7\\\\\\\\\\\\\\\/6lD21s6O188rRYvXj9xnYmBrwElqfSLfiRykjwJpaoEl4InTmcSJ+QbjUdS5YhtYSdQP11Mx1m48dcf1MVtsXD6pOq93jmR5jRMSq9nShM\\\\\\\\\\\\\\\/0v1YdABFe8CVGBZJOjsh\\\\\\\\\\\\\\\/rmr1q1mhbKxnDQK24820Md3qa2h9WVNser4cVwQI+BjyfJzkXgMosOnBwVj5nOMS8Vfh84YqoNhM9vBNEn9tfvw9FwP13wZjYKKBwSVw3NH2mLxt9gunzu7bqvcRe5Wty0vxc4HMPK3XEFvE2l3Fgvtd5hOSqDmr8xbFQypiaEwpwewSpeG96OXdvBiu19WlgcCFCD4\\\\\\\\\\\\\\\/OHy\\\\\\\\\\\\\\\/DA6eRG2ihn\\\\\\\\\\\\\\\/vDAETZS6+Z0ofjGpVdPsovchfF332Oyyjy+fVF1F+oEQ3W4b2pyUphGiBaSbe\\\\\\\\\\\\\\\/zXPbWCb2WNQrurOBBWyxmAkh+MF5aOA\\\\\\\\\\\\\\\/C6t9Z7Ii0IAECUik+81FNhB+eUgwHWzovvv25lVX5SFO3r9lqOvqSBsgLro2lUT+Jeot0oZrk6GzgaEhN8jg2\\\\\\\\\\\\\\\/t7FOiKhcbhLiFAsuhcOWt4PaGtbvWDzfVrF1JUdml8TAx7YxD+GZt0etI8pFOWXyesmiVXpYWDn8O2PPk5+aQe02KxQ8OW8KndrFcYzgNigrEjZjTdiKYm9cLglIi8ScXfI8dZFXjaDNXIPdIM+GrwrZWOHuIkvvRvVm2XdJp+sJmY1BQ\\\\\\\\\\\\\\\/+CIf7VaJipMgVm7JE3ng+lZrm\\\\\\\\\\\\\\\/ermM0j5s6KgCEA30gp7oO4vHFoPXjYiB0mjabq54gurTneg3Y9UBDBfblAHcA4c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mQEQjnaksxTYp7A\\\\\\\\\\\\\\\/vEVMxg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228f6c9341c85b4cdf1d2b417433d3946be48a25e6f483195259e74636ccaefc67\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/2\\\/e004871.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/2\\\/e004871.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004871\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004871\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004871\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}