{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221hTPRqzezPG4MDUDwJMiK3XFyxrKUe5UzW72QKcIoJqXLnYUpTzD9TpQKBNtMpKk\\\\\\\\\\\\\\\/CkFlRRM2qUG+ezWcKFvcm0\\\\\\\\\\\\\\\/VuQy9L9psrkzaaXw\\\\\\\\\\\\\\\/ONnvqYlMt6SR+QiEBFQn4ewqpE79NQK3FCUupxTL3qVXeYfdU7htorKIRudvfhij5+LMAMkjl+\\\\\\\\\\\\\\\/e33NMNLMNjkhKX9ciTbHFa7lyxGxJyb2Snv4fLEdPcQ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+3mu3ywpN3VC3URUOMxss40tCF3SLUbxUKDMAV+h+C6PVonTmdHk4frgneEmdQZne\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/RHXEO8xR4DIFpgjS2ACwhK\\\\\\\\\\\\\\\/2qDdhW98P5bgdoDC2HeNPIA\\\\\\\\\\\\\\\/Qizq+BrEAtBigREncDVOMwalfmSYt060h6Ztd6yXY2DS2iKt2qbKwNd5K5+eLDavSjfxMpqfpI+8g+X2wRM397zslrjxaVslF87NbJFs7mEhUj8UtodIrDpJDmh+AOviyyJBmLsvGMK9Xpta750M7ELTSkpRkP8NTND0aJA2QLjCqOPNOzVNAZVtwlRTIISpxD78gkP9rNEmHHgni8DDV3BDr3hEzsYcXp9kXlGj337exq7p0qdmda3Tw60qgrY3gDDalCeJJ2yWnDZ+GcMb+ddDZdDA9d7oOi0orR8HO5jy64xuiNsfYgDaLDhvVPJowatcFHDN6xE5Yoe9ZA0BRB5uNsXqcS2vNFyIm391D73\\\\\\\\\\\\\\\/uQXV2JKVC8XNCjREC2UzP0YoIIeZegJ6VooEOEcELo81jCoAMNsaUNeECEhkqm8Y9qSoG7o0nB+Aw4yyFJiBwsmXy5mpctAIHRYy5SDcgab2edfH8njTO5rZJjIBJ37+1VYBA9\\\\\\\\\\\\\\\/OQ4RVOi1m99QMxOAnr7FHXh2Q\\\\\\\\\\\\\\\/cE1FbPhO4zCJYnIBUOGwCidKOxt3Cbp4x6ikSzwITyPo1O461xlZQRUeo6N9wlkcoFWEYn530pI2CzgAXsQ3E2ND0MVHBmhetxrWDo4s9SSyDLCgEnR4HUdpYINzL29t9oAYz\\\\\\\\\\\\\\\/C7XpGlYTgw29QeCrIY2ish\\\\\\\\\\\\\\\/THlk400FYz3r7MOSVoK8UMJjVx3Iuz1d7aHLwtr2JqiJ48A\\\\\\\\\\\\\\\/PpcvTq0Tc+0xxjiz+w2o1kDHJ3MyJaB5gjMCzhyYrLSMvmzhEiIYJ4SKRtRLrNr0gteCPoWS7t\\\\\\\\\\\\\\\/iJVMOox1\\\\\\\\\\\\\\\/I3EjF9yIXAGXG97Z3GaOdKInd7ivc93xIpt7BcRJB+\\\\\\\\\\\\\\\/HD1jukDjrKLmdD7+CKiMpefdmHdQKqK16oAsE1GdTOYPIGwvT6+9UrSdWvtNOPy5K9WL\\\\\\\\\\\\\\\/2KtZwsIE6eB4FbQnJozg68xBH6\\\\\\\\\\\\\\\/2I8NbNICytcv9OcAGycYAiPV6u6B\\\\\\\\\\\\\\\/71uqMuXBNDM7tP1K2ASaLyk86r7jJqpn57wXyafKs24YYZXGv4P90z6kbVgCq4Vy4aUkK8fnghj45QgwaTi9kjzT0oIPByMAr0OrfXZqQHDA9C\\\\\\\\\\\\\\\/4cRyTAqJEfgk6pyFuMp7OHAWznWOWZYTfB1D1tUeeCyINN5gGQCspIP3wWmpMP4BZOj4S7hLbFDIHKDqg6W\\\\\\\\\\\\\\\/jP8SSChrJaK0azNm9nHtcZXH1nDzE6QvUVfwngON+qKyySxBIWnkamO\\\\\\\\\\\\\\\/ow9gyzplRtz3Kw7Bi90V+YBo1VTiZmEt25nHXAG9UelbkuZwouPjV83OkNiWZ2Yi6mcO0FMpRQlBqyVQs6DZT0ug4ZzQJuJJtgrjpmAYqPVtPkcqeNN4idfNAIVGLfhkxdjatYom+SESVz5b4xwGxe+Ze1LwNsiROnRGO1lXHha48CNyoAeO90cjAbukAshGe4IuWHhULn+ZmGim54Kr2HBRuP8CR+YA7dblC3R15RkNbv\\\\\\\\\\\\\\\/dwb8ux2LZuuM3vq2nFZEvmEcwBUdYzAh7GugrzOxFIW3stUn\\\\\\\\\\\\\\\/MBfhbRIvLBLGeWtgYK586FLkEdw+LNlh1SGbXQQmDmBMZJusYVjd+OIH3Ps4nO6xpSi5f6g3LnvTjeQovTmAgxZA+scindalYjpy0g+YmxHYDeSXTrtZTBCm5Cf4pTO9no7uAolhjLPd4KTJVSZdcVptWKND8pynBBDvvI7QitEquBJGpuWqgmuyjkzUQMYxeGi0MBiaTySf2d7gtmKEFLH2qqprtA7Mxpa7q5G6cFqk8dmNhVT3251fXgLoaTM4xOkEKn8t+jSeTQplRW7wA2KnGuU05cIwPoXMThiQISbvdG9EdAFR6qThiR+uhBbbZ+eParY6sIw\\\\\\\\\\\\\\\/2mXg8NtoC3eCqH66Mpg4v7R3wuJOcvhHYzXeYReiJ\\\\\\\\\\\\\\\/M0u0xjMPLS0adn5VuWPTc0FfY5rYxlxL6\\\\\\\\\\\\\\\/0+yYJ5xAl7VDzfAggVyyEb8VY5QdHdmAh4ol10DpHWUxn0KFxBIXkwr9i9pR36HVP5BSy6LR0MD2fL5brvmeGkI5vDpsQ0vGgyUUzNGupC5Z3p67TGd7kVQZpfKdjWNUBlOIPzDn9FYt+7cJ0xoP3J8nyNzQebWr1iTXKstHTCBcDK0k1oOyNS3lQjkQh6Lsy2XPNREVIYDCrvPuj8rfZOit2S9LnjX6Wubaj57w3O2UqDjjz4y5T7VDlcZmKhiHJQj2r2yogMGmaF96swLqMPMDGIMrCFTnPJA5kJly5WXwOiI4ivO15JGD3CUl9rn3PXMTeMUPo93Oc3k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022FRiggP77o1sw34iYa3xpsQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002205c0b9c8d09a27722a1c8ef809f43cbb04bfe56d966bc13b76a6a76403c133b7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/13.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/13.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0058-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0058-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0058-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}