{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022+WLF89cXVM8UvXO0YHpCuS6YnbrYa0WqnlCLHmJoVcf1asghTEr4XhAhTY3iQ4WDa9lsa37EqYVvPFRn9xk\\\\\\\\\\\\\\\/4uwYow87QVpLybwDLzN8E9bDE5FBaGGeit4EP+3INYqmKF9Y+ajlZI8b1LiF5Z89\\\\\\\\\\\\\\\/122YM0UDM2BPl33ycEaHEktdhbnUzmSJMAkOyXiR+5mkXnTWLzEiPkPWxctJHfaHKPg8K2fDca2IBA5TnePjz7S9Mqxh1BC7Ls9JeDbF2QXfLM7x+DWjoYq3WDlTIJUlDQN1edBdBd5z\\\\\\\\\\\\\\\/DNg\\\\\\\\\\\\\\\/VtScsCdOsdFmqtgiswgr5If10iT2wLFL2tQkhcDhpqSseRpc4+5pGuZNPgbYZnonMpX851bVr+oH9WAuUg\\\\\\\\\\\\\\\/gRuLatRmq4YMsyN9jaSY9gqULWtq9CDOKT48pE9OSFrWqPmjIDvE432YS1nDNK\\\\\\\\\\\\\\\/fb1f1YGUp4Yr6CTQjnObHfEsEO6AXVhs81ztIfjo9+bQiLXqwAr2NyKWBT0tzQO2z74dm\\\\\\\\\\\\\\\/uH5FJ1w59Ix+noUk81CcxxvTHq3adtlXPO7sPihbjr2HfSSFkEq6ycCedn9nKEXP3uBL8A+dt+MAEcLgEiLKpefbol2rzxZwPqP2UXNiTAl+tnFM5OhhsxAVzUC\\\\\\\\\\\\\\\/UCmDvm6dHVcCQJH602k7l3ss3yZnzW9uUWYeesZoyRaXLI6InNDs3iYH\\\\\\\\\\\\\\\/JyuEb31Lm0mT+RLd8Ps3hGrB+S05A\\\\\\\\\\\\\\\/8J7m9NfaXxrLDXsDz29pbZdnfRQv6nYyf3+ZgFgWhAcwQSbFUBA\\\\\\\\\\\\\\\/WU25Xpe+qYjCOQINOB2Nyw4S165Tc+MnGJlntdWeBIS9IUCJFMMNS0MFdsQY9YK47isIBDlV5tgZhYcNdIXixPV7T\\\\\\\\\\\\\\\/aXWiZkyJZojoxHuv\\\\\\\\\\\\\\\/HNKH14Ftze9grmboJCpLUF8A4fMIWz06IX5Gay47qCHM1caT+8\\\\\\\\\\\\\\\/NAaoepCxEvsgu4G9zcBSHHxdMYfxTaSUxfp4Yd7qhFjN\\\\\\\\\\\\\\\/comvZWW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/r+pFO9uttVars8a2STjWqCmzA220c716nTX0ITFgYbaQul305LcyAU+v6ib4UYsl0HAqkUz818XN4LEqLVOX8\\\\\\\\\\\\\\\/P1wDpCOgSiH4saEVmrSbmZxdnDG4Va2CHoS\\\\\\\\\\\\\\\/VXukus+8no8RBHgHXy64SE+pn83FqReCtiBViaFyyP4eUUoBpqUvjjGfmQxEJY2AAOEs9jxpd2VxZ0Toy5JmEVOcbMdVYlmGg501pc9gtPAH\\\\\\\\\\\\\\\/oLxWR3wkQVLa2GqKQo9ntmSuEsJUMo3Oan\\\\\\\\\\\\\\\/5H2PvOdLl\\\\\\\\\\\\\\\/MR1b8wg004qSmydfN+LfIupshFQwYSovZ9NY\\\\\\\\\\\\\\\/kuENgsQSiNdNGnnasJPrQ9vbSA75Q13nZnb3QLT3LFnhA3Ogo39+BAEzpvDLAgQRtC4obGHjdNNdQHqtlLi2vT\\\\\\\\\\\\\\\/r1D1XJgue3ERmnRBT+mSjrvKP7KsHph01vYM3QczpYzhJlTnJjXgT71g\\\\\\\\\\\\\\\/dOVKBWQmzhml9IeXuQ1g4Nse4aBVmyHnrX33ObdXgkqcfadAP6FJS1tkBX0cJmzHridv07YWyP2+mGeQAF9+Nky2x\\\\\\\\\\\\\\\/H5KQItIAfhPId7Tex7yEcYQEPlauQB\\\\\\\\\\\\\\\/BTO9zeohC\\\\\\\\\\\\\\\/TTEQRdYMkERusXGHLeK8Zx2l7rqphXgpjilIxceCCB91RDeaehil36Zf6H6vR15J2Uqi9\\\\\\\\\\\\\\\/DEIatAltLC3X5AqjeNcKXI3MPke2pDSDlwwFiCrEBuLsVdQMSnu6mpRkePM\\\\\\\\\\\\\\\/4GlC2\\\\\\\\\\\\\\\/kJuzsaOxlgEy4SOGy6NfmVKOhvYMT1dj6UVubH6y\\\\\\\\\\\\\\\/Af+8n4BsWbHIVTLUTaWFPryYi4p62PEYRMoVJda+Yz00lzq6VR2nBDCO6Dg9Or0vwNnD3P6XxGJgXrztCnUV2y7pgaWEJ7vBtwzKLIwN0apWX2QtOJpkN121Vs2lmc6wMqXWxtKNDuKTeX6kNMryUDHxfz5qB29rki3ymn2hFOZyUiERMW67FIai58ItUH6iWrKD5dvSzxjvdR2okiPtvyI3MGAsCVbqvtJVlC+A9soYQVqbn0fMU0mCSsDEVwIOPrRPhh0qfAkbRKKDavcRyMB6VBY+qQqxg+msjdRwUXtRVZaKZ\\\\\\\\\\\\\\\/6e9Ajj+7lyazsk0gvxmT5g5vOppA7OEuAekkoxT9W7FNcqEgXOiqeVXbw7P6+9K\\\\\\\\\\\\\\\/0fHczYk4vyIki2Wr2h46Fy5BIDPRSewCtq9CGKIPPkTspcwCoipdu\\\\\\\\\\\\\\\/Jg+qdeLPfFl\\\\\\\\\\\\\\\/2Yh9T7HjpbEPe0QOiU7Y9BE9Ee6aIxD63aeFSwJefo2mrTGkYfaglEgqi16h\\\\\\\\\\\\\\\/+MClSt2SNHh1pq6AIRsRmp8TeTw2rxUrMTTh1b\\\\\\\\\\\\\\\/RcCJn7jHUOxcX4JAGslWMFMhCvGN5RQ6LL\\\\\\\\\\\\\\\/dCv1BX8M1+M9JimrvTgfPJkW\\\\\\\\\\\\\\\/FlnRtr7HU04SEQeIl2W3pbcEzPlxYWwSt2Rld4pJJ5p4M8ZFkmXN9VYXzMC\\\\\\\\\\\\\\\/PopFaueNOP\\\\\\\\\\\\\\\/IscBtAYf0Ip1s7Hsw\\\\\\\\\\\\\\\/e8HglvW63nGxzvlXaw5ZXCsUJ5CYRn37jau\\\\\\\\\\\\\\\/S8frPAhPmYLk4Y\\\\\\\\\\\\\\\/FUfL50UYBGyoky6eCumHgoLylGivhEIIlf8OEK1qyHj\\\\\\\\\\\\\\\/gVL9eEGUmZNgYpW6\\\\\\\\\\\\\\\/k+jj7IcUDMulXbc9Z9rZkDIa0QQDv4kvxkmaXDCVf7Cr0X2vO9WJheQw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229gwcuwqA8UO+0u+I0YVGbw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227bcebe163be84b51db1008a6f98454427a863a458df82ecd13d5dae7ecda89fb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e006024.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e006024.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006024\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006024\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006024\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}